Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Koichi Wakabayashi"'
Autor:
Daiki Tanaka, Hiroaki Yaguchi, Kaichi Yoshizaki, Akihiko Kudo, Fumiaki Mori, Taichi Nomura, Jing Pan, Yasuo Miki, Hidehisa Takahashi, Taichi Hara, Koichi Wakabayashi, Ichiro Yabe
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Tauopathy is known to be a major pathognomonic finding in important neurodegenerative diseases such as progressive supranuclear palsy (PSP) and corticobasal degeneration. However, the mechanism by which tauopathy is triggered remains to be elucidated
Externí odkaz:
https://doaj.org/article/ef7fa3a565924534a94f64be46902425
Autor:
Yasuo Miki, Yuki Takeuchi, Shingo Murasawa, Shinobu Takayasu, Fumiyasu Tsushima, Shingo Kakeda, Hiroki Mizukami, Koichi Wakabayashi
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-5 (2022)
Abstract Background Neurological symptoms and radiographic abnormalities may remain in a small proportion of patients with metronidazole-induced encephalopathy (MIE). Although experimental animal models of MIE have suggested a Wernicke’s encephalop
Externí odkaz:
https://doaj.org/article/c5bab90961ca4ad1b18b2bdae405c42c
Autor:
Takashi Nakamura, Haruo Nishijima, Fumiaki Mori, Iku Kinoshita, Tomoya Kon, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyama
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundA rat model of levodopa-induced dyskinesia (LID) showed enlarged axon terminals of striatal direct pathway neurons in the internal segment of the globus pallidus (GPi) with excessive gamma-aminobutyric acid (GABA) storage in them. Massive G
Externí odkaz:
https://doaj.org/article/8e72c11db69c4f649fdb33c6c2404a46
Autor:
Masako Fujita, Tatsuya Ueno, Yasuo Miki, Akira Arai, Hidekachi Kurotaki, Koichi Wakabayashi, Masahiko Tomiyama
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Amyotrophic lateral sclerosis (ALS) is one of the differential diagnoses of diseases that occur in adulthood and lead to progressive generalized muscle weakness. Neuronal intranuclear inclusion disease (NIID) is a disease in which histopathologically
Externí odkaz:
https://doaj.org/article/635ba11d106b4e79bd7467c55e228580
Autor:
Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Hidekachi Kurotaki, Masahiko Tomiyama, Tomohiko Ishihara, Osamu Onodera, Akiyoshi Kakita, Koichi Wakabayashi
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pT
Externí odkaz:
https://doaj.org/article/8eb056c89c6d461683f4ea0e7688ae21
Autor:
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota Tatara, Junsei Mimura, Máté János Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8433 (2022)
Sulforaphane (SFN) is a potent activator of the transcriptional factor, Nuclear Factor Erythroid 2 (NF-E2)-Related factor 2 (NRF2). SFN and its precursor, glucoraphanin (sulforaphane glucosinolate, SGS), have been shown to ameliorate cognitive functi
Externí odkaz:
https://doaj.org/article/ed394f45afa144b7af48e9609b7d80f5
Autor:
Haruo Nishijima, Tamaki Kimura, Fumiaki Mori, Koichi Wakabayashi, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Masahiko Tomiyama
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
BackgroundIt remains unclear why patients with young-onset Parkinson’s disease more often develop levo-dihydroxyphenylalanine (L-dopa)-induced dyskinesia (LID) and have a more severe form than patients with old-onset Parkinson’s disease. Previous
Externí odkaz:
https://doaj.org/article/09ec6a4f7b8544d4bfa5f46563860bb6
Autor:
Kunikazu Tanji, Yasuo Miki, Fumiaki Mori, Yoshikazu Nikaido, Hidemi Narita, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 339-349 (2019)
Multiple system atrophy (MSA) is an adult-onset neurodegenerative disorder clinically characterized by autonomic failure in addition to various combinations of symptoms of parkinsonism, cerebellar ataxia, and pyramidal dysfunction. Despite extensive
Externí odkaz:
https://doaj.org/article/b4c09dc7352a4755950e02214ff22479
Autor:
Jun Liu, Shuya Kasai, Yota Tatara, Hiromi Yamazaki, Junsei Mimura, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Kunikazu Tanji, Koichi Wakabayashi, Hayato Maeda, Hiroki Mizukami, Yasuhiro Shinkai, Yoshito Kumagai, Hirofumi Tomita, Ken Itoh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3201 (2022)
GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that Gcn1 mutant mice lacking the GCN2-binding domain suffer from growt
Externí odkaz:
https://doaj.org/article/8e518720faf048c0ba956cdf00949372
Autor:
Haruo Nishijima, Fumiaki Mori, Akira Arai, Gang Zhu, Koichi Wakabayashi, Motohiro Okada, Shinya Ueno, Noritaka Ichinohe, Chieko Suzuki, Tomoya Kon, Masahiko Tomiyama
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 104979- (2020)
Levo-dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease; however, most patients develop uncontrollable abnormal involuntary movements known as L-DOPA-induced dyskinesia. L-DOPA-induced dyskinesia can be reduced by
Externí odkaz:
https://doaj.org/article/00325d2a238a40c68eeeadc965d452f8