Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Koichi Uyemura"'
Autor:
Albert M. Song, Moon K. Song, H Yang, Dean T. Yamaguchi, Koichi Uyemura, Mark J. Rosenthal, EM Cornford, ME Ament
Publikováno v:
British Journal of Pharmacology. 158:442-450
Background and purpose: We have previously shown that treatment with zinc plus cyclo-(His-Pro) (CHP) significantly stimulated synthesis of the insulin degrading enzyme and lowered plasma insulin and blood glucose levels, alongside improving oral gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d390df93b780cc1174f4cfb5adecd20d
https://doi.org/10.1111/j.1476-5381.2009.00201.x
https://doi.org/10.1111/j.1476-5381.2009.00201.x
Publikováno v:
Clinics in Geriatric Medicine
Immunosenescence results in populating immune tissues with less functional T cells, and perhaps B cells dendritic cells, that do not function well and produce more type 2 cytokines and fewer type 1 cytokines. Impaired immunity, distinct from immunose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202c08132fc214d3d459d527516d1ea1
https://doi.org/10.1016/j.cger.2007.03.005
https://doi.org/10.1016/j.cger.2007.03.005
Publikováno v:
Journal of the American Geriatrics Society. 53:1565-1569
Objectives: To determine whether high level of comorbidity, measured using a standardized instrument, can predict impaired immunity in older adults. Setting: Geriatric outpatient Clinic and Nursing Home Care Unit of Veterans Affairs Greater Los Angel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3552201bd241de44cc8d767effecba2b
https://doi.org/10.1111/j.1532-5415.2005.53512.x
https://doi.org/10.1111/j.1532-5415.2005.53512.x
Publikováno v:
Journal of Molecular and Genetic Medicine.
This review article evaluates the current knowledge in the prevention and treatment of diabetes and obesity. The relative abundance of food and lack of rigorous exercise common in modern life pose serious challenges in the incidence and treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ad98fc324753974bbe5eaa1707b85a1
https://doi.org/10.4172/1747-0862.s1-009
https://doi.org/10.4172/1747-0862.s1-009
Autor:
Koichi Uyemura, Ari Miller, Peter A. Sieling, Joshua R. Bleharski, Katia Schlienger, Jenny Kim, Hans Brightbill, Paul S. Yamauchi, Thomas H. Rea, Robert L. Modlin
Publikováno v:
The Journal of Immunology. 165:1506-1512
The interaction of CD40 ligand (CD40L) expressed by activated T cells with CD40 on macrophages has been shown to be a potent stimulus for the production of IL-12, an obligate signal for generation of Th1 cytokine responses. The expression and interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220c3d3599fb8f63ec9cf7410972693a
https://doi.org/10.4049/jimmunol.165.3.1506
https://doi.org/10.4049/jimmunol.165.3.1506
IL-18 Promotes Type 1 Cytokine Production from NK Cells and T Cells in Human Intracellular Infection
Autor:
Verónica E. García, Koichi Uyemura, Peter A. Sieling, María T. Ochoa, Craig T. Morita, Haruki Okamura, Masashi Kurimoto, Thomas H. Rea, Robert L. Modlin
Publikováno v:
The Journal of Immunology. 162:6114-6121
We investigated the role of IL-18 in leprosy, a disease characterized by polar cytokine responses that correlate with clinical disease. In vivo, IL-18 mRNA expression was higher in lesions from resistant tuberculoid as compared with susceptible lepro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f563cfac43e7f24419ba114b07d3f6d3
https://doi.org/10.4049/jimmunol.162.10.6114
https://doi.org/10.4049/jimmunol.162.10.6114
Autor:
Katia Schlienger, Koichi Uyemura, Denis Jullien, Peter A. Sieling, Thomas H. Rea, Peter S. Linsley3, Robert L. Modlin
Publikováno v:
The Journal of Immunology. 161:2407-2413
We used human leprosy as a model to compare patterns of costimulatory molecule expression in respect to the clinical/immunologic spectrum of disease. We found that B7-1, B7-2, and CD28 transcripts dominated in tuberculoid leprosy patients, who have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11957dc35807c3405f4be80da50fc98a
https://doi.org/10.4049/jimmunol.161.5.2407
https://doi.org/10.4049/jimmunol.161.5.2407
Autor:
Verónica E. García, Denis Jullien, Mark Song, Koichi Uyemura, Ke Shuai, Craig T. Morita, Robert L. Modlin
Publikováno v:
The Journal of Immunology. 160:4322-4329
Human γδ T cells have the ability to rapidly expand and produce IFN-γ in response to nonpeptide Ags of microbial pathogens, in particular a class of compounds known as the prenyl phosphates. We investigated the ability of IL-15, a T cell growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca901a5e6be922751412855f24070677
https://doi.org/10.4049/jimmunol.160.9.4322
https://doi.org/10.4049/jimmunol.160.9.4322
Publikováno v:
Mechanisms of Ageing and Development. 94:7-16
Peripheral blood mononuclear cells (PBMC) of frail elderly nursing home residents had significantly higher PHA-induced interleukin-10 (IL-10) production compared to PBMC's from young control subjects. No correlation was observed between IL-10 product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41aeddf0965f5a329a76252e9784366a
https://doi.org/10.1016/s0047-6374(96)01821-0
https://doi.org/10.1016/s0047-6374(96)01821-0