Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Koichi Tsubone"'
Autor:
Ann Vos, Lieve Lammens, Richard Alexander, Frederik J. R. Rombouts, Michel Surkyn, Kenji Morimoto, Laurent Leclercq, Nigel Austin, Koichi Tsubone, Tatsuhiko Ueno, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Ken-ichi Kusakabe, Ard Teisman, Diederik Moechars, Tom Jacobs, An Van Den Bergh, Hirokazu Sumiyoshi, Herman Borghys, Shunsuke Einaru, Soufyan Jerhaoui, Brian Joel Hrupka, Harrie J.M. Gijsen
Publikováno v:
Journal of Medicinal Chemistry. 64:14175-14191
The discovery of a novel 2-aminotetrahydropyridine class of BACE1 inhibitors is described. Their pKa and lipophilicity were modulated by a pending sulfonyl group, while good permeability and brain penetration were achieved via intramolecular hydrogen
Publikováno v:
Tetrahedron. 67:6600-6615
A stereocontrolled synthesis of a fully elaborated GHIJ-ring fragment of gambieric acids, which are potent antifungal polycyclic ether natural products, has been accomplished. The synthesis features convergent assembly of the tetracyclic polyether sk
Publikováno v:
Tetrahedron Letters. 52:548-551
A stereocontrolled synthesis of the GHIJ-ring fragment having a side chain of gambieric acids, which are potent antifungal polycyclic ether natural products, has been achieved. The synthesis features convergent assembly of the tetracyclic polyether s
Autor:
Ryuichi Sakai, Koichi Tsubone, Geoffrey T. Swanson, L. Leanne Lash-Van Wyhe, Olli T. Pentikäinen, Pekka A. Postila, Makoto Sasaki
Publikováno v:
Neuropharmacology. 58:640-649
Kainate receptor antagonists have potential as therapeutic agents in a number of neuropathologies. Synthetic modification of the convulsant marine toxin neodysiherbaine A (NDH) previously yielded molecules with a diverse set of pharmacological action
Autor:
Muneo Shoji, Nobuyuki Akiyama, Keiko Shimamoto, Ryuichi Sakai, Makoto Sasaki, Kunimori Aoki, Koichi Tsubone, Masato Oikawa
Publikováno v:
The Journal of Organic Chemistry. 73:264-273
A rapid and efficient total synthesis of dysiherbaine (1), a potent and subtype-selective agonist for ionotropic glutamate receptors, has been accomplished. A key intermediate 15 was synthesized by two approaches. The first synthetic route utilized c
Publikováno v:
Tetrahedron Letters. 48:5697-5700
An efficient total synthesis of dysiherbaine, a potent and subtype-selective agonist for ionotropic glutamate receptors, has been achieved. An advanced key intermediate in the previous synthesis of neodysiherbaine A and its analogues was selected as
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5784-5787
To enable studies to elucidate the detailed biological function of dysiherbaine and neodysiherbaine A, potent and subunit-selective agonists for ionotropic glutamate receptors, the derivative with a hydroxymethyl substituent at the C10 position has b
Autor:
Masato Oikawa, Keiko Shimamoto, Ryuichi Sakai, Geoffrey T. Swanson, Nobuyuki Akiyama, Koichi Tsubone, L. Leanne Lash, Muneo Shoji, James M. Sanders, Makoto Sasaki
Publikováno v:
The Journal of organic chemistry. 71(14)
Dysiherbaine (1) and its congener neodysiherbaine A (2) are naturally occurring excitatory amino acids with selective and potent agonistic activity for ionotropic glutamate receptors. We describe herein the total synthesis of 2 and its structural ana