Zobrazeno 1 - 10 of 48 pro vyhledávání: '"Koichi Sugeno"'
1
Absorption, distribution and excretion of 883-S (ceruletide diethylamine) in rats
Autor: Kazuhiro Inazawa, Koichi Sugeno, Hideo Tanaka, Takeo Yoshimori, Shinya Futaguchi, Hiroshi Okabe
Publikováno v: Drug Metabolism and Pharmacokinetics. 5:331-343
The absorption, distribution and excretion of 883-S(ceruletide diethylamine), a new agent against dyskinesia, were studied in rats using 14C-883-S. Radioactivity in the plasma decreased rapidly during 30min after i.v. administration (0.1mg/kg) follow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47494e1634e6538fac7602f95285e2c2
https://doi.org/10.2133/dmpk.5.331
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2
Studies on the Metabolic Fate of Mometasone furpate(MF). (IV). Metabolism in Rats and Rabbits
Autor: Yuji Okada, Kazuo Kamata, Shin-ichi Ninomiya, Kenji Mizojiri, Toshio Esumi, Atsuhiro Inaba, Koichi Sugeno, Sadao Aoyama, Matsuo Takaichi
Publikováno v: Drug Metabolism and Pharmacokinetics. 5:827-843
Metabolic fate of 14C-MF in the rat and the rabbit was studied after subcutaneous administration at 0.5mg/kg dose. The metabolites were analyzed by two-dimensional TLC, located by autoradiography and quantitated by TLC scraping and counting of the ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::374054655924500e71a8387da75ed73a
https://doi.org/10.2133/dmpk.5.827
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4
Studies on theMetabolic Fate of Mometasone furoate(MF). (II). Absorption, Distribution, Excretion after Subcutaneous Administration to Rats and Rabbits
Autor: Koichi Sugeno, Hideaki Seki, Yoshio Esumi, Matsuo Takaichi, Takayuki Miyake, Kenji Mizojiri
Publikováno v: Drug Metabolism and Pharmacokinetics. 5:795-817
The absorption, distribution and excretion of radioactivity following a single or multiple subcutaneous administration of 14C-MF in rats were studied.1. When 14C-MF was administered at 0.5 or 1 mg/kg, a dose independent values of Cmax (26 ?? 30ng equ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e9d89554ecc1569094caf0f28ad8fe
https://doi.org/10.2133/dmpk.5.795
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5
Studies on the Metabolic Fate of Mometasone furoate(MF). (III). Transfer into the Fetus and Milk
Autor: Yoshio Esumi, Takayuki Miyake, Hideaki Seki, Matsuo Takaichi, Kenji Mizojiri, Koichi Sugeno
Publikováno v: Drug Metabolism and Pharmacokinetics. 5:819-825
Foeto-placental transfer and excretion into the milk of radioactivity was studied following subcutaneous administration of 14C-MF to pregnant or lactating rats at the dose of 0.5mg/kg.1. On day 13 of gestation, no radioactivity was detected in the fe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::202f4a8670853fbf810c94d54b0604be
https://doi.org/10.2133/dmpk.5.819
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7
Studies on the metabolism of 883-S (ceruletide diethylamine) in rats
Autor: Koichi Sugeno, Hitoshi Arita, Shinya Futaguchi, Tohru Nakano, Keiko Kawamoto
Publikováno v: Drug Metabolism and Pharmacokinetics. 5:353-364
Metabolism of 883-S (ceruletide diethylamine) was studied in rats after intravenous administration of 14C-883-S (alpha carbon of glycine residue was labeled with 14C).The plasma level of unchanged 883-S rapidly decreased after injection. The level of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54e76f661a55f74768508fd92977df7b
https://doi.org/10.2133/dmpk.5.353
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8
Binding affinities of mometasone furoate and related compounds including its metabolites for the glucocorticoid receptor of rat skin tissue
Autor: Hitoshi Shimizu, Mitsutaka Isogai, Toshihiko Okada, Yoshio Esumi, Koichi Sugeno, Tadao Terasawa
Publikováno v: The Journal of steroid biochemistry and molecular biology. 44(2)
The binding affinities of mometasone furoate (MF), its metabolites and related compounds for the glucocorticoid receptor of rat epidermis and dermis were measured. MF and its main metabolite exhibited binding affinities higher than those of alclometh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bd50a0c83fd0f258834b36fab37d88
https://pubmed.ncbi.nlm.nih.gov/8439518
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9
Pharmacokinetics of a novel hypnotic, 450191-S, in elderly patients
Autor: Shinichi Kobayashi, Hajime Yasuhara, Masao Kono, Koichi Sugeno, Hideo Yamada, Koji Sakamoto
Publikováno v: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 19:617-624
A new hypnotic, 450191-S, was administered to five elderly patients [cerebral thrombosis: two patients (81 yr and 78 yr), gastric cancer: one patient (61 yr); chronic hepatitis: twopatients (78 yr and 70 yr)]. Pharmacokinetic behaviors of this drug i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1cc4c7d15e59ddfadee4405299b9357
https://doi.org/10.3999/jscpt.19.617
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10
Studies on the metabolic fate of S-3460. (IV). Metabolism and protein binding
Autor: Matsuo Takaichi, Sadao Aoyama, Kenji Mizojiri, Naoko Saito, Shinya Hanawa, Kazuo Kamata, Koichi Sugeno, Hideaki Tohjo, Yoshio Esumi
Publikováno v: Drug Metabolism and Pharmacokinetics. 3:83-99
The metabolism of 14C-S-3460 in rats, rabbits and mice was studied after subcutaneous administration at dose of 0.5 mg/kg. Plasma protein binding was also determined. 1. Plasma metabolites. The main metabolite was 21-hydroxy compound ((2)) and unchan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b614bcab4597f4166513bc43c39cf7a1
https://doi.org/10.2133/dmpk.3.83
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