Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Koichi R. Katsumura"'
Autor:
Mabel Minji Jung, Siqi Shen, Giovanni A. Botten, Thomas Olender, Koichi R. Katsumura, Kirby D. Johnson, Alexandra A. Soukup, Peng Liu, Qingzhou Zhang, Zena D. Jensvold, Peter W. Lewis, Robert A. Beagrie, Jason K.K. Low, Lihua Yang, Joel P. Mackay, Lucy A. Godley, Marjorie Brand, Jian Xu, Sunduz Keles, Emery H. Bresnick
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a patient with leukemia predisposition syndrome (GATA2 deficiency) with a germline GATA2 variant
Externí odkaz:
https://doaj.org/article/0a1d39017eb14888912ea7fe69a08151
Autor:
Vu L. Tran, Peng Liu, Koichi R. Katsumura, Erin Kim, Bjorn M. Schoff, Kirby D. Johnson, Emery H. Bresnick
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106297- (2023)
Summary: Innate immune signaling protects against pathogens, controls hematopoietic development, and functions in oncogenesis, yet the relationship between these mechanisms is undefined. Downregulating the GATA2 transcription factor in fetal hematopo
Externí odkaz:
https://doaj.org/article/5f3b08aa83854df7811358f16b3aa550
Autor:
Charu Mehta, Kirby D. Johnson, Xin Gao, Irene M. Ong, Koichi R. Katsumura, Skye C. McIver, Erik A. Ranheim, Emery H. Bresnick
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2966-2979 (2017)
Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. GATA-2-regulated enhancers increase Gata2 expression in hematopoietic stem/progenitor cells and control hematopoie
Externí odkaz:
https://doaj.org/article/5f5db142b9614d63809ec53cb53732d3
Autor:
Koichi R. Katsumura, Irene M. Ong, Andrew W. DeVilbiss, Rajendran Sanalkumar, Emery H. Bresnick
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2428-2441 (2016)
The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), and GATA2 overexpression portends
Externí odkaz:
https://doaj.org/article/03d9ad82289d4dafad3c908e67edd8bd
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/5/2024, Vol. 121 Issue 10, p1-12, 52p
Autor:
Emery H. Bresnick, Elvira Deolinda Rodrigues Pereira Velloso, Lucy A. Godley, Marcela Cavalcante de Andrade Silva, Koichi R. Katsumura, Charu Mehta
Publikováno v:
Leukemia. 35:264-268
Publikováno v:
Blood Adv
The surge of human genetic information, enabled by increasingly facile and economically feasible genomic technologies, has accelerated discoveries on the relationship of germline genetic variation to hematologic diseases. For example, germline variat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdeb2d1802294a49036896ac9f31d28
https://europepmc.org/articles/PMC7509867/
https://europepmc.org/articles/PMC7509867/
Autor:
Peng Liu, Weixin Wang, Evgenia Shishkova, Sean Kraus, Katherine R. Calvo, Daniel J Conn, Siqi Shen, Kirby D. Johnson, Joshua J. Coon, Erik A. Ranheim, Sunduz Keles, Steven M. Holland, Koichi R. Katsumura, Emery H. Bresnick, Amy P. Hsu
Publikováno v:
The Journal of Experimental Medicine
By elevating levels of the GATA2 transcription factor in hematopoietic progenitor cells, a transcriptional enhancer establishes multilineage differentiation potential. During embryogenesis, deleting the enhancer upregulates innate immune machinery an
Autor:
Marcela, Cavalcante de Andrade Silva, Koichi R, Katsumura, Charu, Mehta, Elvira D R P, Velloso, Emery H, Bresnick, Lucy A, Godley
Publikováno v:
Leukemia. 35(1)
Autor:
Emery H. Bresnick, Skye C. McIver, Erik A. Ranheim, Irene M. Ong, Xin Gao, Kirby D. Johnson, Koichi R. Katsumura, Charu Mehta
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2966-2979 (2017)
GATA-2 levels must be stringently regulated to ensure normal hematopoiesis, and human GATA-2 mutations cause hematologic disorders. GATA-2-regulated enhancers differentially control Gata2 expression in hematopoietic stem/progenitor cells and are esse