Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Koichi Orino"'
Autor:
Yasunaga Yoshikawa, Shunta Kimura, Akira Soga, Makoto Sugiyama, Aki Ueno, Hiroki Kondo, Zida Zhu, Kazuhiko Ochiai, Kazuhiko Nakayama, Jun Hakozaki, Kodai Kusakisako, Asako Haraguchi, Taisuke Kitano, Koichi Orino, Shinya Fukumoto, Hiromi Ikadai
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Background Malaria is a major global parasitic disease caused by species of the genus Plasmodium. Zygotes of Plasmodium spp. undergo meiosis and develop into tetraploid ookinetes, which differentiate into oocysts that undergo sporogony. Homo
Externí odkaz:
https://doaj.org/article/935d800dc697423692d63b9d014567a4
Autor:
Zida Zhu, Taisuke Kitano, Masami Morimatsu, Kazuhiko Ochiai, Toshina Ishiguro-Oonuma, Kosuke Oosumi, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Publikováno v:
Veterinary Sciences, Vol 10, Iss 2, p 145 (2023)
Mammary tumors are the most prevalent type of tumors in female dogs. Breast cancer 2, early onset (BRCA2) malignant mutations are associated with tumorigenesis in humans and dogs. BRCA2 plays a pivotal role in homologous recombination repair by recru
Externí odkaz:
https://doaj.org/article/4c9362d3e1f744d0b3a60d73bb4625c8
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and downregulation of i
Externí odkaz:
https://doaj.org/article/73711d55f8654af6b1476b0741faec9d
Autor:
Zida Zhu, Taisuke Kitano, Masami Morimatsu, Arisa Tanaka, Ryo Morioka, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4060 (2022)
Breast cancer type 2 susceptibility (BRCA2) protein is crucial for initiating DNA damage repair after chemotherapy with DNA interstrand crosslinking agents or X-ray irradiation, which induces DNA double-strand breaks. BRCA2 contains a C-terminal RAD5
Externí odkaz:
https://doaj.org/article/f18587456c5341f9a218ae260db81cd2
Publikováno v:
Antibodies, Vol 3, Iss 1, Pp 169-181 (2014)
Anti-ferritin autoantibodies are found in many animals. Human ferritin-binding proteins (FBPs) were partially purified from human serum by ion-exchange chromatography and immobilized metal affinity chromatography with Zn2+. Crude FBPs were immunocopr
Externí odkaz:
https://doaj.org/article/6316fbfd7ce746dabdb375b74f887f80
Publikováno v:
Antibodies, Vol 5, Iss 2, p 13 (2016)
Human immunoglobulin G (IgG) binding with zinc ions was examined using zinc ions immobilized on chelating Sepharose beads (Zn-beads). Human IgG bound to Zn-beads but not to Sepharose beads (control beads). Mouse, rat, bovine and equine IgGs also boun
Externí odkaz:
https://doaj.org/article/420cdae2d50342c292f9adebd325afa1
Autor:
Yasunaga Yoshikawa, Kazuhiko Ochiai, Masami Morimatsu, Yu Suzuki, Seiichi Wada, Takahiro Taoda, Satomi Iwai, Seishiro Chikazawa, Koichi Orino, Kiyotaka Watanabe
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45833 (2012)
Mammary tumors are the most common tumor type in both human and canine females. Mutations in the breast cancer susceptibility gene, BRCA2, have been found in most cases of inherited human breast cancer. Similarly, the canine BRCA2 gene locus has been
Externí odkaz:
https://doaj.org/article/d14019450f704dcdb8f967758160f580
Ferritin, iron storage protein, binds heme on its surface although it’s physiological role has not been elucidated yet. Firstly, this study analyzed the bindings of bovine and horse spleen ferritins to beads immobilized with α-casein (CasB) with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a4207a4bdb44b35ad3c01946048b686
https://doi.org/10.21203/rs.3.rs-2611327/v1
https://doi.org/10.21203/rs.3.rs-2611327/v1
Autor:
Michio Katagi, Haruka Imatomi, Yasushiko Tsuchida, Kinya Katayama, Yasunaga Yoshikawa, Koichi Orino
Publikováno v:
Austral Journal of Veterinary Sciences; 2023, Vol. 55 Issue 3, p197-202, 19p
Autor:
Koichi Orino
Publikováno v:
BioMetals. 33:287-291
Bovine milk proteins bind calcium and some bind other metal ions or heme. The examination of heme-binding proteins in colostrum and milk using hemin-agarose beads (HA) showed α-casein, κ-casein and lactoferrin (Lf) to be heme-binding proteins. α-C