Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Koichi Masuno"'
Autor:
Kazuhisa Minami, Minoru Hasegawa, Hisanori Ito, Atsushi Nakamura, Takako Tomii, Mitsunobu Matsumoto, Satoshi Orita, Syuichi Matsushima, Takako Miyoshi, Koichi Masuno, Mikinori Torii, Katsumi Koike, Shinji Shimada, Toshiyuki Kanemasa, Tsuyoshi Kihara, Minoru Narita, Tsutomu Suzuki, Akira Kato
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 1, Pp 60-72 (2009)
Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain. We investigated whether these opioids possess different efficacy profiles on several types of pain in mouse pain models. When the three opioids were
Externí odkaz:
https://doaj.org/article/008c1894dc1248a68fb930e82144eebf
Autor:
Takeki Uehara, Shinpei Yamaguchi, Toru Nakano, Yoshiharu Matsuura, Toru Okamoto, Hiroyuki Oka, Koichi Masuno
Publikováno v:
Toxicology. :68-75
The genotoxic potential of drugs is a serious problem, and its evaluation is one of the most critical processes of drug development. Although the comet assay of compound-exposed tissue is a frequently used genotoxicity test, its high false-positive r
Autor:
Jyoji Yamate, Mitsuru Kuwamura, Takeshi Izawa, Noriko Tsuchiya, Kae Fujisawa, Mikinori Torii, Koichi Masuno, Yuki Kato, Atsuko Hishikawa
Publikováno v:
Experimental and Toxicologic Pathology. 69:413-423
We herein investigated the histopathological features, including proliferative activity and immunoexpression, of pancreatic islet cell tumors (ICTs) in male SD rats induced by streptozotocin (STZ) and nicotinamide (NA), and discussed their relevance
Autor:
Ken ichi Nezasa, Eugene P. Frenkel, Toru Wada, Satomi Shinonome, Keiji Dohi, Kanji Hojo, Michitaka Shichijo, Koichi Masuno, T. Yamada, Motofumi Iguchi, Norihito Sato, Hidekazu Tanaka, Tatsuya Sugimoto, Shuji Yonezawa, Yukichi Ishioka, Kenji Matsuo, Makiko Inoue, Michinari Hirata
Publikováno v:
Cancer Science
Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are validated molecular targets in cancer therapy. Dual blockade has been explored and one such agent, lapatinib, is in clinical practice but with modest acti
Autor:
Shuuichi Matsushima, Koichi Masuno, Kae Fujisawa, Akihiro Hirata, Nobuo Takasu, Yuki Kato, Emi Kashiwagi-Yamamoto
Publikováno v:
Journal of Toxicologic Pathology
The development of ectopic gastric, intestinal, or pancreatic tissue in the gastrointestinal tract is extremely rare in rats, although it is fairly common in humans. In this report, we describe an unusual case in which a mixture of different types of
Autor:
Koichi Masuno, Shosaku Hattori, Yasuhiro Fukuda, Yutaka Nakai, Masahito Kubo, Chieko Kai, Tokuma Yanai, Junpei Kimura, Takeshi Kuraishi, Ryo Ikarashi
Publikováno v:
Journal of Veterinary Medical Science. 76:169-172
Cryptosporidium andersoni and Cryptosporidium muris infections have been found in the mice and/or cattle. The oocysts of C. andersoni and C. muris have been sporadically detected in human feces, but the infectious capacity and features have been unkn
Autor:
Takao Inoue, Koichi Masuno, Kumiko Takemori, Kimura Takashi, Norifumi Shirasaka, Hiroyuki Ito
Publikováno v:
Life Sciences. 88:1088-1094
Aims To determine the effects of food restriction (FR) on the expression of Sirt1 and its down-stream factors related to lipid and glucose metabolism in obese and hypertensive rats (SHRSP/IDmcr-fa), as a model of human metabolic syndrome. Main method
Autor:
Nobuhiro Isobe, Koichi Masuno, Masaki Tsuruki, Masao Sakane, Morio Yorikawa, Noriaki Matsuda, Yuji Ohata, Akira Yoshinari
Publikováno v:
Journal of the Society of Materials Science, Japan. 60:94-101
This paper proposes a method of inelastic structural analysis for YH61 nickel base single crystal superalloy. Hill's anisotropic constitutive equation was applied to describe the elastic-plastic deformation of the superalloy. The equation well descri
Publikováno v:
Journal of Toxicologic Pathology
A young male Crl:CD (SD) rat with erythroid leukemia that presented with emaciation, abdominal distension and a pale visible mucosal membrane was euthanized at 7 weeks of age. At necropsy, enlargement of liver, spleen and pancreatic lymph node was no
Autor:
Takeki Uehara, Manabu Okada, Satoshi Inoue, Mikinori Torii, Takako Miyoshi, Noriko Tsuchiya, Toshiyuki Maruyama, Koichi Masuno, Jyoji Yamate
Publikováno v:
Human & Experimental Toxicology. 26:767-780
To elucidate the mechanism of nephrotoxicity caused by anti-neoplastic platinum complex, nedaplatin (NDP), treatment with a particular focus on the renal papillary toxicity, we analysed the gene expression profiles of two renal regions, the cortex (R