Výsledky vyhledávání - "Koichi Katsuyama"

Expression and localization of insulin-like growth factor binding proteins in normal and proteinuric kidney glomeruli

Autor: Yutaka Yoshida, Eishin Yaoita, Tadashi Yamamoto, Koichi Katsuyama, Hidehiko Fujinaka, Keiko Yamamoto, Masaaki Nameta, Shuichi Tomizawa

Publikováno v: Nephrology. 15:700-709

Aim: Insulin-like growth factor I (IGF-I) acts on target cells in an endocrine and/or local manner through the IGF-I receptor (IGF-IR), and its actions are modulated by multiple IGF binding proteins (IGFBP). To elucidate the roles of local IGFBP in k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::155bb1a864413fcc3ea963853674fbba
https://doi.org/10.1111/j.1440-1797.2010.01285.x

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Influenza vaccination for severely multiply handicapped persons/children in the 2005–2006 season

Autor: Masashi Iizawa, Satoru Kinoshita, Reiko Saito, Shuichi Tomizawa, Koichi Katsuyama, Hiroshi Suzuki, Yasuki Tanaka, Hidehiko Fujinaka, Taketo Otsuka

Publikováno v: Vaccine. 25:4521-4524

In this study, we report the effectiveness of trivalent inactivated influenza vaccination (TIV) for severely multiply handicapped persons/children (SMHPs) in the 2005-2006 season. In 77 SMHPs, A/New York/55/2004 (H3N2) which was the changed vaccine-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065b12ce874080993c4d248e61ea05eb
https://doi.org/10.1016/j.vaccine.2007.03.041

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Blockade of nuclear factor-κB activation prevents hypodynamic shock and gastric hypoperfusion induced by endotoxin in anesthetized dogs

Autor: Yutaka Narumi, Chieko Mitaka, Kuninori Yokoyama, Koshi Makita, Takasuke Imai, Koichi Katsuyama, Yukio Hirata

Publikováno v: Intensive Care Medicine. 31:718-723

To investigate whether pyrrolidinone derivative (N2733), an inhibitor of nuclear factor (NF)-kappaB activation, improves altered metabolic and hemodynamic changes and organ dysfunctions caused by endotoxic shock.Prospective, randomized, animal study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80f58f9eafe0ef2bcadbb97c69028ee
https://doi.org/10.1007/s00134-005-2617-1

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Cytokine-activated Jak-2 is involved in inducible nitric oxide synthase expression independent from NF-κB activation in vascular smooth muscle cells

Autor: Shinya Ishimaru, Masaru Doi, Masayoshi Shichiri, Koichi Katsuyama, Yukio Hirata

Publikováno v: Atherosclerosis. 160:123-132

Inflammatory cytokines, such as interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha, activate nuclear factor-kappa B (NF-kappaB) which transactivates inducible nitric oxide synthase (iNOS) gene in vascular smooth muscle cells (VSMCs). Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdaf55f70c8fb2caa194e90b650610a9
https://doi.org/10.1016/s0021-9150(01)00578-0

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A Pyrrolidinone Derivative Inhibits Cytokine-Induced iNOS Expression and NF- B Activation by Preventing Phosphorylation and Degradation of I B

Autor: Koichi Katsuyama, Yukio Hirata

Publikováno v: Journal of Biochemistry. 129:585-591

We previously showed that 1-[3-(3-pyridyl)-acryloyl]-2-pyrrolidinone hydrochloride (N2733) inhibits lipopolysaccharide (LPS)-induced tumour necrosis factor (TNF)-alpha secretion and improves the survival of endotoxemic mice. Since overproduction of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4104a9a91d20f324885a4eca0d670cb1
https://doi.org/10.1093/oxfordjournals.jbchem.a002894

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Role of Nuclear Factor-κB Activation in Cytokine- and Sphingomyelinase-Stimulated Inducible Nitric Oxide Synthase Gene Expression in Vascular Smooth Muscle Cells**This work was supported in part by grants-in-aid from the Ministry of Education, Science, and Culture and the Ministry of Health and Welfare of Japan

Autor: Koichi Katsuyama, Masayoshi Shichiri, Fumiaki Marumo, Yukio Hirata

Publikováno v: Endocrinology. 139:4506-4512

Inflammatory cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα), are known to activate sphingomyelinase (SMase) and nuclear factor-κB (NF-κB) in certain cell types, which also stimulate inducible nitric oxide synthase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a59999c46c9abda610e28762f6887ae
https://doi.org/10.1210/endo.139.11.6309

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NO Inhibits Cytokine-Induced iNOS Expression and NF-κB Activation by Interfering With Phosphorylation and Degradation of IκB-α

Autor: Masayoshi Shichiri, Fumiaki Marumo, Yukio Hirata, Koichi Katsuyama

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 18:1796-1802

Abstract —Nitric oxide (NO) is known to have antiatherogenic and anti-inflammatory properties, but its effects on the cytokine-induced nuclear factor-kappa B (NF-κB) activation pathway in relation to the regulation of inducible nitric oxide syntha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85979d23bfc723c7e9042164a8c3ac7b
https://doi.org/10.1161/01.atv.18.11.1796

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Expression and localization of insulin-like growth factor binding proteins in normal and proteinuric kidney glomeruli

Autor: Hidehiko, Fujinaka, Koichi, Katsuyama, Keiko, Yamamoto, Masaaki, Nameta, Yutaka, Yoshida, Eishin, Yaoita, Shuichi, Tomizawa, Tadashi, Yamamoto

Publikováno v: Nephrology (Carlton, Vic.). 15(7)

Insulin-like growth factor I (IGF-I) acts on target cells in an endocrine and/or local manner through the IGF-I receptor (IGF-IR), and its actions are modulated by multiple IGF binding proteins (IGFBP). To elucidate the roles of local IGFBP in kidney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17fe2df56b1677808e8de5cf7baa7884
https://pubmed.ncbi.nlm.nih.gov/21040165

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Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors

Autor: Takashi Komine, Muneki Nagao, Hiroyasu Takahashi, Masashi Suzuki, Koichi Katsuyama, Mariko Shinoyama, Hisatoshi Tsuchida

Publikováno v: Bioorganicmedicinal chemistry letters. 21(6)

Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d651693d5d85055a8d6887e7d92686
https://pubmed.ncbi.nlm.nih.gov/21316233

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Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus

Autor: Hidehiko Fujinaka, Tadashi Yamamoto, Shuichi Tomizawa, Masaaki Nameta, Koichi Katsuyama, Makoto Uchiyama, Yutaka Yoshida, Eishin Yaoita, Keiko Yamamoto

Publikováno v: Nephron. Experimental nephrology. 113(2)

Background/Aims: A chemokine fractalkine (FKN/CX3CL1) is induced primarily by endothelial cells and accumulates inflammatory cells via its receptor CX3CR1. Since glomerular preferential expression of FKN/CX3CL1 gene was reported in normal human kidne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52587eb0c5087d681ae530ffa4906605
https://pubmed.ncbi.nlm.nih.gov/19590241

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