Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Koichi Araki"'
Autor:
Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses ef
Externí odkaz:
https://doaj.org/article/dfaca50a88f74b02a4c1d34e9ba0a73c
Autor:
Scott M. Krummey, Anna B. Morris, Jesica R. Jacobs, Donald J. McGuire, Satomi Ando, Katherine P. Tong, Weiwen Zhang, Jennifer Robertson, Sara A. Guasch, Koichi Araki, Christian P. Larsen, Brian D. Evavold, Haydn T. Kissick, Mandy L. Ford
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1282-1291.e5 (2020)
Summary: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RB
Externí odkaz:
https://doaj.org/article/d69652ad5ff041889716115077fdfc7b
Autor:
Kumari Lokugamage, Hiroaki Kariwa, Daisuke Hayasaka, Bai Zhong Cui, Takuya Iwasaki, Nandadeva Lokugamage, Leonid I. Ivanov, Vladimir I. Volkov, Vladimir A. Demenev, Raisa Slonova, Galina Kompanets, Tatyana Kushnaryova, Takeshi Kurata, Kenji Maeda, Koichi Araki, Tetsuya Mizutani, Kumiko Yoshimatsu, Jiro Arikawa, Ikuo Takashima
Publikováno v:
Emerging Infectious Diseases, Vol 8, Iss 8, Pp 768-776 (2002)
In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two
Externí odkaz:
https://doaj.org/article/08371d60e36543b4bac5aac17e0e1fb0
Autor:
Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn T. Kissick, William H. Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James L. Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jorg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed
Publikováno v:
Nature. 610:173-181
Autor:
Satomi, Ando, Koichi, Araki
Publikováno v:
International Immunology. 34:571-577
Persistent antigenic stimulation results in loss of effector function or physical deletion of antigen-specific CD8 T cells. This T-cell state is called T-cell exhaustion and occurs during chronic infection and cancer. Antigen-specific CD8 T cells dur
Autor:
Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Publikováno v:
The Journal of clinical investigation.
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8 T cells are maintained by self-renewing stem-like T (TSL) cells that provide differentiated TIM3+ cells, a part of which possess
Autor:
Masao, Hashimoto, Koichi, Araki, Maria A, Cardenas, Peng, Li, Rohit R, Jadhav, Haydn T, Kissick, William H, Hudson, Donald J, McGuire, Rebecca C, Obeng, Andreas, Wieland, Judong, Lee, Daniel T, McManus, James L, Ross, Se Jin, Im, Junghwa, Lee, Jian-Xin, Lin, Bin, Hu, Erin E, West, Christopher D, Scharer, Gordon J, Freeman, Arlene H, Sharpe, Suresh S, Ramalingam, Alex, Pellerin, Volker, Teichgräber, William J, Greenleaf, Christian, Klein, Jorg J, Goronzy, Pablo, Umaña, Warren J, Leonard, Kendall A, Smith, Rafi, Ahmed
Publikováno v:
Nature
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection(1). Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 combination therapy, unlike PD-1 monot
Autor:
Arlene H. Sharpe, Jeanne Cheung, Bryan Irving, Gordon J. Freeman, Koichi Araki, Rafi Ahmed, James L. Riley, Eunseon Ahn, Weiyan Li, Masao Hashimoto
Publikováno v:
Proceedings of the National Academy of Sciences. 115:4749-4754
PD-1 (programmed cell death-1) is the central inhibitory receptor regulating CD8 T cell exhaustion during chronic viral infection and cancer. Interestingly, PD-1 is also expressed transiently by activated CD8 T cells during acute viral infection, but
Autor:
Haydn T. Kissick, Xiaodong Cheng, Eunseon Ahn, Erin E. West, Xiaojin Xu, Andreas Wieland, Rustom Antia, Ben Youngblood, Rafi Ahmed, Bogumila T. Konieczny, Carl W. Davis, Koichi Araki, Yiping Fan, Pranay Dogra, Hazem E. Ghoneim, J. Scott Hale
Publikováno v:
Nature
Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an essential component of long-lived T cell immunity. These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-exposure to pathogens,
Autor:
Nahum Sonenberg, Rafi Ahmed, Annelise G. Bederman, Koichi Araki, Haydn T. Kissick, Bogumila T. Konieczny, Masahiro Morita
Publikováno v:
Nature Immunology. 18:1046-1057
Translation is a critical process in protein synthesis, but translational regulation in antigen-specific T cells in vivo has not been well defined. Here we have characterized the translatome of virus-specific CD8+ effector T cells (Teff cells) during