Zobrazeno 1 - 10
of 794
pro vyhledávání: '"Kohzoh IMAI"'
Autor:
Tomohiro KUROKAWA, Kohzoh IMAI
Publikováno v:
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, Vol 100, Iss 5, Pp 293-308 (2024)
Multifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan, has emer
Externí odkaz:
https://doaj.org/article/eda47006b47b48f686fcf6a5c22de8b5
Publikováno v:
FEBS Open Bio, Vol 8, Iss 10, Pp 1733-1741 (2018)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer that is typically diagnosed at a later stage with metastases and is difficult to treat. Therefore, investigating the mechanism of PDAC initiation is important to aid early‐s
Externí odkaz:
https://doaj.org/article/2cc6a5609daa44c7b61eaf916a4a5fd5
Autor:
Koji Ueno, Mikako Hiura, Yutaka Suehiro, Shoichi Hazama, Hiroshi Hirata, Masaaki Oka, Kohzoh Imai, Rajvir Dahiya, Yuji Hinoda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 7, Pp 697-705 (2008)
We investigated whether one of the Wnt receptors, frizzled-7 (FZD7), functions in the canonical Wnt signaling pathway of colorectal cancer (CRC) cells harboring an APC or CTNNB1 mutation and may be a potential therapeutic target for sporadic CRCs. Th
Externí odkaz:
https://doaj.org/article/542ac7ff24614c96941d9812f20bfcdd
Autor:
Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner, Hiromu Suzuki, Joo-Mi Yi, Timothy A Chan, Leander Van Neste, Wim Van Criekinge, Sandra van den Bosch, Manon van Engeland, Angela H Ting, Kamwing Jair, Wayne Yu, Minoru Toyota, Kohzoh Imai, Nita Ahuja, James G Herman, Stephen B Baylin
Publikováno v:
PLoS Genetics, Vol 3, Iss 9, Pp 1709-1723 (2007)
We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a pan
Externí odkaz:
https://doaj.org/article/255e50ac950f447a90f132b7d3c8660a
Autor:
Kei Onodera, Yoshiaki Arimura, Hiroyuki Isshiki, Kentaro Kawakami, Kanna Nagaishi, Kentaro Yamashita, Eiichiro Yamamoto, Takeshi Niinuma, Yasuyoshi Naishiro, Hiromu Suzuki, Kohzoh Imai, Yasuhisa Shinomura
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137801 (2015)
BackgroundThe common disease-common variant hypothesis is insufficient to explain the complexities of Crohn's disease (CD) genetics; therefore, rare variants are expected to be important in the disease. We explored rare variants associated with susce
Externí odkaz:
https://doaj.org/article/c280df85d1ee41dbb9a1c02d43fae2bd
Autor:
Shohei Yamamoto, Makoto Otsu, Emiko Matsuzaka, Chieko Konishi, Haruna Takagi, Sachiyo Hanada, Shinji Mochizuki, Hiromitsu Nakauchi, Kohzoh Imai, Kohichiro Tsuji, Yasuhiro Ebihara
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120841 (2015)
Induced pluripotent stem (iPS) cells provide powerful tools for studying disease mechanisms and developing therapies for diseases. The 8p11 myeloproliferative syndrome (EMS) is an aggressive chronic myeloproliferative disorder (MPD) that is caused by
Externí odkaz:
https://doaj.org/article/82f6b38e3d2f435fb48a40604239471b
Autor:
Motohisa Yamamoto, Hiroki Takahashi, Keisuke Ishigami, Hidetaka Yajima, Yui Shimizu, Tetsuya Tabeya, Mikiko Matsui, Chisako Suzuki, Yasuyoshi Naishiro, Hiroyuki Yamamoto, Kohzoh Imai, Yasuhisa Shinomura
Publikováno v:
International Journal of Rheumatology, Vol 2012 (2012)
Objectives. The characteristic features of Mikulicz’s disease (MD) are diffuse enlargement of the lacrimal and submandibular glands, elevated levels of serum immunoglobulin (Ig)G4, and abundant infiltration of IgG4-positive plasmacytes into both gl
Externí odkaz:
https://doaj.org/article/adc3a6ddf1934beeafb84255a167b8fe
Autor:
Koichiro Yuji, Seiya Imoto, Rui Yamaguchi, Tomoko Matsumura, Naoko Murashige, Yuko Kodama, Satoru Minayo, Kohzoh Imai, Masahiro Kami
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50410 (2012)
INTRODUCTION: Japan is rapidly becoming a full-fledged aged society, and physician shortage is a significant concern. The Japanese government has increased the number of medical school enrollments since 2008, but some researchers warn that this incre
Externí odkaz:
https://doaj.org/article/3b6ffa4cb6a440989cf9badd30f7e30e
Autor:
Shigeru Sasaki, Tadao Ishida, Minoru Toyota, Akinobu Ota, Hiromu Suzuki, Akinori Takaoka, Hiroshi Yasui, Hiroyuki Yamamoto, Hideyasu Takagi, Masahiro Maeda, Tsutomu Seito, Masayuki Tsujisaki, Yasuhisa Shinomura, Kohzoh Imai
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19618 (2011)
BACKGROUND: Hepatocellular carcinoma (HCC) is the most commonly occurring primary liver cancer and ranks as the fifth most frequently occurring cancer, overall, and the third leading cause of cancer deaths, worldwide. At present, effective therapeuti
Externí odkaz:
https://doaj.org/article/c03f8c733270491ba5e6b343b6a0c283
Autor:
Masaaki Adachi, Yaohua Liu, Kyoko Fujii, Stuart K Calderwood, Akira Nakai, Kohzoh Imai, Yasuhisa Shinomura
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7719 (2009)
BACKGROUND:Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there hav
Externí odkaz:
https://doaj.org/article/011e99ed05814537947b048fcf87a3ab