Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kohtarou Kodama"'
Publikováno v:
Life Sciences. 78:134-139
Inhibitory effects of highly purified vitamin B2 (riboflavin-5'-sodium phosphate, >97%) on the interleukin (IL)-6, macrophage inflammatory protein (MIP)-2 and nitric oxide (NO) in LPS-induced shock mice were evaluated. Vitamin B2 at 20 mg/kg (protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e1aec153c65472933eba4f351fab1a
https://doi.org/10.1016/j.lfs.2005.04.037
https://doi.org/10.1016/j.lfs.2005.04.037
Publikováno v:
European Journal of Pharmacology. 492:273-280
We investigated the effect of an i.v. infusion of highly purified vitamin B(2) (riboflavin 5'-sodium phosphate: purity >97%) on lipopolysaccharide-induced shock and bacterial infection in mice. Six hours after lipopolysaccharide injection or 1 h afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a5f0dcf88e420c5a01193117d554f0
https://doi.org/10.1016/j.ejphar.2004.04.004
https://doi.org/10.1016/j.ejphar.2004.04.004
Publikováno v:
European Journal of Pharmacology. 396:43-47
The radial artery is currently used as a viable arterial conduit for myocardial revascularization. The aims of this study were to identify phosphodiesterase 3 isoenzyme in the human radial artery isolated for coronary artery bypass grafting, and to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc0dc96c4c0fb79da52ed0c687dee02
https://doi.org/10.1016/s0014-2999(00)00190-4
https://doi.org/10.1016/s0014-2999(00)00190-4
Autor:
Yasuhiro Kabasawa, Kohtarou Kodama, Y. Takase, Nobuhisa Watanabe, Kazuki Miyazaki, Hideyuki Adachi, Hiroki Ishihara, Masayuki Matsukura
Publikováno v:
Journal of Medicinal Chemistry. 41:3367-3372
We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted phthalazines (16) and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) purified from porcine platelets. The PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5c054ef5994186ef1c7005d4510e27
https://doi.org/10.1021/jm970815r
https://doi.org/10.1021/jm970815r
Publikováno v:
Japanese Journal of Pharmacology. 73:73-82
We compared the antianginal effect of E4080, a novel bradycardic agent with coronary vasodilating properties, with those of a bradycardic agent and some coronary vasodilators in vasopressin-induced anginal model of guinea pigs. An i.v.-administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e3b1d703ea0f97ac50274877b8d54a
https://doi.org/10.1254/jjp.60.73
https://doi.org/10.1254/jjp.60.73
Autor:
Masayuki Matsukura, Yasuhiro Kabasawa, Y. Takase, Kohtarou Kodama, Kazuki Miyazaki, Hideyuki Adachi, Hiroki Ishihara, Nobuhisa Watanabe
Publikováno v:
ChemInform. 29
We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted phthalazines (16) and evaluated their inhibitory activity toward phosphodieste...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f8d5d465e560b35b7bbc29e31aad25
https://doi.org/10.1002/chin.199851179
https://doi.org/10.1002/chin.199851179
Publikováno v:
Infection and immunity. 72(3)
Highly purified vitamin B2 (riboflavin 5′-sodium phosphate; purity > 97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb45dd867323dc3bf00005fa5e38b76
https://pubmed.ncbi.nlm.nih.gov/14977995
https://pubmed.ncbi.nlm.nih.gov/14977995
Publikováno v:
European journal of pharmacology. 493(1-3)
The aim of this experiment was to clarify whether an amino acid supplement could enhance the therapeutic effect of vitamin B2 (riboflavin 5'-sodium phosphate; purity > 97%) in mice with lipopolysaccharide-induced shock. Six hours after injection of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa73fd5fa809e34d0a6091848331cf
https://pubmed.ncbi.nlm.nih.gov/15189780
https://pubmed.ncbi.nlm.nih.gov/15189780
Autor:
Masayuki Matsukura, Hiroki Ishihara, Nobuhisa Watanabe, Hirofumi Ozaki, Yasutaka Takase, Kohtarou Kodama, Motoharu Kakiki, Mayu Nishino, Kazuki Miyazaki, Yasuhiro Kabasawa, Keiji Ishibashi, Hideyuki Adachi
Publikováno v:
Journal of medicinal chemistry. 43(13)
We synthesized various 4-(3-chloro-4-methoxybenzyl)aminophthalazines substituted at the 1- and 6-positions and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) and their vasorelaxant activity in isolated porcine coronary arteries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d9f4995f004dd40722f7785b53dcb0
https://pubmed.ncbi.nlm.nih.gov/10891111
https://pubmed.ncbi.nlm.nih.gov/10891111
Publikováno v:
Journal of pharmacological and toxicological methods. 41(4)
The present study was performed to determine whether measurement of penile diameter in an in vivo rat model is useful for pharmacologic and physiologic investigations on penile erection. Penile erection induced by electrical stimulation of the cavern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ee60c9800304cf966b5d37bf982ffd
https://pubmed.ncbi.nlm.nih.gov/10691019
https://pubmed.ncbi.nlm.nih.gov/10691019