Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kohtaro Yasuda"'
Autor:
Hiroaki Fujiwara, Takashi Ishizaki, Teruji Tanaka, Kohtaro Yasuda, Hirotoshi Echizen, Akihiro Ohnishi
Publikováno v:
Clinical pharmacology and therapeutics. 51(4)
In an effort to characterize an interaction between the eicosanoids and sympathoadrenal system on platelet aggregation, we tried to determine if a sustained thromboxane A2 (TXA2) synthase inhibition would modulate changes in eicosanoid formation, cat
Publikováno v:
Journal of pharmaceutical sciences. 80(8)
A random walk method for predicting percutaneous drug absorption pharmacokinetics was proposed. The profiles predicted by this method were compatible with those predicted by the analytical method. The random walk method is particularly useful for pre
Autor:
Kohtaro Yasuda, Shigeyuki Terashita, Tomoichi Fujiwara, Hideyo Noguchi, Akira Shishido, Masato Terakawa, Yoji Tokuma, Kikuko Nakagawa
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:649-655
Urinary metabolite profile of nilvadipine, a new dihydropyridine calcium antagonist, was examined in 6 healthy male volunteers given the drug in single and repeated oral doses. The drug was given first in a single oral dose of 4 mg, and after washout
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 20:735-740
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigatedin healthy subjects following single oral doses of 10, 30, 60, and 120mg. For 30, 60, and 120mg, 5 subjects were studied for each dose ; for 10 mg, only 2 subj
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 20:741-749
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigated in healthy subjects following single intravenous doses of 25, 50, and 100mg and during and after the 7 days repeated doses of 100mg per day . Each dose was st
Publikováno v:
Journal of clinical pharmacology. 27(4)
The effect of two different meals on the bioavailability of nilvadipine, a new antihypertensive and antianginal drug, was examined in 16 healthy male volunteers in two separate studies. In each study of eight subjects in a Latin-square, two-way cross
Publikováno v:
Journal of clinical pharmacology. 29(10)
A placebo-controlled, randomized, crossover study was conducted to assess a possible effect of a dihydropyridine Ca-entry blocker, nifedipine, on urinary concentration ability in nine healthy men under a water-deprivated condition. Placebo and nifedi
Publikováno v:
The Japanese Journal of Veterinary Science. 30:241-250_2
Chicks were given 0, 3, 9, and 27 ppm of pyrimethamine contained in a diet for12 consecutive weeks and examined both clinically and histopathologically. The healingprocess of the pyrimethamine-induced Iesion was also observed.l. Clinically, chicks ex