Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Kohtaro Minami"'
Autor:
Sachiho Kida, Yuri Koshimura, Eiji Yoden, Aya Yoshioka, Hideto Morimoto, Atsushi Imakiire, Noboru Tanaka, Satowa Tanaka, Ayaka Mori, Jun Ito, Asuka Inoue, Ryuji Yamamoto, Kohtaro Minami, Tohru Hirato, Kenichi Takahashi, Hiroyuki Sonoda
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 439-449 (2023)
Mucopolysaccharidosis I (MPS I), a lysosomal storage disease caused by dysfunction of α-L-iduronidase (IDUA), is characterized by the deposition of dermatan sulfate (DS) and heparan sulfate (HS) throughout the body, which causes several somatic and
Externí odkaz:
https://doaj.org/article/c4fd5548bc6941a2962304a79b9b0f89
Autor:
Hideto Morimoto, Hiroki Morioka, Atsushi Imakiire, Ryuji Yamamoto, Tohru Hirato, Hiroyuki Sonoda, Kohtaro Minami
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 534-544 (2022)
Deposition of heparan sulfate (HS) in the brain of patients with mucopolysaccharidosis II (MPS II) is believed to be the leading cause of neurodegeneration, resulting in several neurological signs and symptoms, including neurocognitive impairment. We
Externí odkaz:
https://doaj.org/article/4eedbba9a32d4c1babcaa2d7cd77f6c7
Autor:
Ryuji Yamamoto, Eiji Yoden, Noboru Tanaka, Masafumi Kinoshita, Atsushi Imakiire, Tohru Hirato, Kohtaro Minami
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 27, Iss , Pp 100758- (2021)
Pabinafusp alfa is a fusion protein comprising a humanized anti-human transferrin receptor (TfR) antibody and human iduronate-2-sulfatase. It was developed as a novel modality to target central nervous system-related symptoms observed in patients wit
Externí odkaz:
https://doaj.org/article/5e52b45ea09645e9b710b6de626d81d7
Autor:
Hiroyuki Sonoda, Kenichi Takahashi, Kohtaro Minami, Toru Hirato, Tatsuyoshi Yamamoto, Sairei So, Kazunori Tanizawa, Mathias Schmidt, Yuji Sato
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1240 (2022)
Enzyme replacement therapy (ERT) has paved the way for treating the somatic symptoms of lysosomal storage diseases (LSDs), but the inability of intravenously administered enzymes to cross the blood–brain barrier (BBB) has left the central nervous s
Externí odkaz:
https://doaj.org/article/cfe1d4edc84946cf9d13f3043a4eadc9
Autor:
Junya Tani, Yae Ito, Satoshi Tatemichi, Makoto Yamakami, Tsuyoshi Fukui, Yukichi Hatano, Shinji Kakimoto, Ayaka Kotani, Atsushi Sugimura, Kazutoshi Mihara, Ryuji Yamamoto, Noboru Tanaka, Kohtaro Minami, Kenichi Takahashi, Tohru Hirato
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231830 (2020)
Renal anemia is predominantly caused by a relative deficiency in erythropoietin (EPO). Conventional treatment for renal anemia includes the use of recombinant human EPO (rhEPO) or a long-acting erythropoiesis-activating agent named darbepoetin alfa,
Externí odkaz:
https://doaj.org/article/ddb54b428f14418bbcd5bef217e7f8b5
Autor:
Naoya Murao, Norihide Yokoi, Kohei Honda, Guirong Han, Tomohide Hayami, Ghupurjan Gheni, Harumi Takahashi, Kohtaro Minami, Susumu Seino
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187213 (2017)
Incretins (GLP-1 and GIP) potentiate insulin secretion through cAMP signaling in pancreatic β-cells in a glucose-dependent manner. We recently proposed a mechanistic model of incretin-induced insulin secretion (IIIS) that requires two critical proce
Externí odkaz:
https://doaj.org/article/0d5dfbcc99b7490f811aac96ca1a34db
Autor:
Ghupurjan Gheni, Masahito Ogura, Masahiro Iwasaki, Norihide Yokoi, Kohtaro Minami, Yasumune Nakayama, Kazuo Harada, Benoit Hastoy, Xichen Wu, Harumi Takahashi, Kazushi Kimura, Toshiya Matsubara, Ritsuko Hoshikawa, Naoya Hatano, Kenji Sugawara, Tadao Shibasaki, Nobuya Inagaki, Takeshi Bamba, Akira Mizoguchi, Eiichiro Fukusaki, Patrik Rorsman, Susumu Seino
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 661-673 (2014)
Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and
Externí odkaz:
https://doaj.org/article/63c84696f9bd4fb8a77b9baf72fed23b
Autor:
Kenji Sugawara, Kohei Honda, Yoshie Reien, Norihide Yokoi, Chihiro Seki, Harumi Takahashi, Kohtaro Minami, Ichiro Mori, Akio Matsumoto, Haruaki Nakaya, Susumu Seino
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164785 (2016)
Insulin secretagogues are used for treatment of type 2 diabetes. We attempted to discover novel small molecules to stimulate insulin secretion by using in silico similarity search using sulfonylureas as query, followed by measurement of insulin secre
Externí odkaz:
https://doaj.org/article/8b7165e325904720a9d9f9b18e168d3f
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126003 (2015)
Glucagon-like peptide-1 (GLP-1) receptor agonists potentiate glucose-induced insulin secretion. In addition, they have been reported to increase pancreatic beta cell mass in diabetic rodents. However, the precise mode of action of GLP-1 receptor agon
Externí odkaz:
https://doaj.org/article/f255d42b5d4c42599b8733d89dbd98d3
Autor:
Hirofumi Noguchi M.D., Ph.D., Shinichi Matsumoto, Teru Okitsu, Yasuhiro Iwanaga, Yukihide Yonekawa, Hideo Nagata, Masayuki Matsushita, Fan-Yan Wei, Hideki Matsui, Kohtaro Minami, Susumu Seino, Yumi Masui, Shiroh Futaki, Koichi Tanaka
Publikováno v:
Cell Transplantation, Vol 14 (2005)
PDX-1 plays a central role in regulating insulin gene transcription and differentiation of insulin-producing cells. It was previously reported that, due to its own Antennapedia-like protein transduction domain (PTD), exogenous PDX-1 protein can perme
Externí odkaz:
https://doaj.org/article/cc4f430465804d7eb976b84171985dec