Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice.

Autor: Alitalo O; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland., Kohtala S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland., Rosenholm M; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Saarreharju R; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland., González-Hernández G; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland; Neuropsychopharmacology and Psychobiology Research Group, Department of Neurosciences, University of Cádiz, Cádiz, Spain., Sarparanta M; Department of Chemistry, University of Helsinki, Finland., Rozov S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland., Rantamäki T; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland. Electronic address: tomi.rantamaki@helsinki.fi.

Publikováno v: Neuropharmacology [Neuropharmacology] 2024 Dec 15; Vol. 261, pp. 110172. Date of Electronic Publication: 2024 Oct 02.

Linking Hypothermia and Altered Metabolism with TrkB Activation.

Autor: Alitalo O; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., González-Hernández G; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Rosenholm M; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark., Kohtala P; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Psychiatry, Weill Cornell Medicine, New York, New York 10021, United States., Matsui N; Faculty of Pharmacy, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani, Gifu 509-0293, Japan., Müller HK; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus N 8200, Denmark., Theilmann W; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland., Klein A; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark.; Department of Drug Design & Pharmacology, University of Copenhagen, Copenhagen DK-2100, Denmark., Kärkkäinen O; School of Pharmacy, University of Eastern Finland, Kuopio 70210, Finland.; Afekta Technologies Ltd., Kuopio 70210, Finland., Rozov S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Rantamäki T; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Kohtala S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland.; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Psychiatry, Weill Cornell Medicine, New York, New York 10021, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2023 Sep 06; Vol. 14 (17), pp. 3212-3225. Date of Electronic Publication: 2023 Aug 08.

Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

Autor: Kohtala, S., Alitalo, O., Rosenholm, M., Rozov, S., Rantamäki, T.

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1593::a65254a498531248aa76fd4418152686
http://hdl.handle.net/10138/330390

Automated Quantification of Human Osteoclasts Using Object Detection.

Autor: Kohtala S; TrollLABS, Department of Mechanical and Industrial Engineering, Faculty of Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Nedal TMV; Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Kriesi C; TrollLABS, Department of Mechanical and Industrial Engineering, Faculty of Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Vitroscope AS, Trondheim, Norway., Moen SH; Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Ma Q; Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Ødegaard KS; Department of Mechanical and Industrial Engineering, Faculty of Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Standal T; Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Hematology, St. Olavs University Hospital, Trondheim, Norway., Steinert M; TrollLABS, Department of Mechanical and Industrial Engineering, Faculty of Engineering, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Jul 05; Vol. 10, pp. 941542. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).

A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants.

Autor: Alitalo O; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland., Saarreharju R; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland., Henter ID; Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, NIMH-NIH, Bethesda, MD, USA., Zarate CA Jr; Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, NIMH-NIH, Bethesda, MD, USA., Kohtala S; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland; Department of Psychiatry, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Rantamäki T; Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Finland. Electronic address: tomi.rantamaki@helsinki.fi.

Publikováno v: Progress in neurobiology [Prog Neurobiol] 2021 Nov; Vol. 206, pp. 102140. Date of Electronic Publication: 2021 Aug 14.