Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kohsuke Yoshida"'
Autor:
Kohjin Suzuki, Kohsuke Yoshida, Takeshi Ueha, Kenta Kaneshiro, Ayako Nakai, Naonori Hashimoto, Koto Uchida, Teppei Hashimoto, Yoshiko Kawasaki, Nao Shibanuma, Natsuko Nakagawa, Yoshitada Sakai, Akira Hashiramoto
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) synovial fibroblasts are incompletely understood. We explored actions of MTX in view of circadian transcriptions of synovial fibroblasts. Methods Unde
Externí odkaz:
https://doaj.org/article/8b83088dd396433a863ece53e6e9ce35
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8941 (2021)
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of
Externí odkaz:
https://doaj.org/article/83964662f0dd4b0aba26bd36d534c0c2
Publikováno v:
Journal of Immunology Research, Vol 2014 (2014)
Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, infla
Externí odkaz:
https://doaj.org/article/b8c9e4b46d55413da0a1a296caa21d08
Publikováno v:
Parkinsonism & Related Disorders. 92:101-104
Chronotropic incompetence (CI) is broadly defined as the inability of the heart to increase its rate commensurate with increased activity. In this study, we tried to clarify the link between CI and UPDRS part II (off-on), which was calculated by subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5111c1d3d28525bc02808d7f6b88fcc4
https://doi.org/10.1016/j.parkreldis.2021.10.022
https://doi.org/10.1016/j.parkreldis.2021.10.022
Autor:
Kohjin Suzuki, Kenta Kaneshiro, Koji Tateishi, Akira Hashiramoto, Nao Shibanuma, Yoshiko Kawasaki, Yasuhiro Terashima, Yoshitada Sakai, Kohsuke Yoshida, Koto Uchida
Publikováno v:
Scandinavian Journal of Rheumatology. 48(5):353-361
Objective: To elucidate the roles of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in cell cycle regulation and proliferation of rheumatoid arthritis fibroblast-like synovial cells (RA-FLSs). Methods: Under stimulation with IL-6/soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d7f1da157e7b24653e73b1e16172bf
https://hdl.handle.net/20.500.14094/90006673
https://hdl.handle.net/20.500.14094/90006673
Autor:
Kenta Kaneshiro, Teppei Hashimoto, Yoshitada Sakai, Kohjin Suzuki, Ayako Nakai, Nao Shibanuma, Kohsuke Yoshida, Koji Tateishi, Natsuko Nakagawa, Koto Uchida, Yoshiko Kawasaki, Akira Hashiramoto, Naonori Hashimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 495(2):1675-1680
Tumor necrosis factor (TNF)-α is responsible for expressions of several clock genes and affects joint symptoms of rheumatoid arthritis (RA) with diurnal fluctuation. We tried to determine the mechanism involved in over-expression of Bmal1, induced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a170b589b666074c2812ca4cef4058
https://hdl.handle.net/20.500.14094/90004689
https://hdl.handle.net/20.500.14094/90004689
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8941, p 8941 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4382e0470fe2becc22dece88a3c173
https://doi.org/10.3390/ijms22168941
https://doi.org/10.3390/ijms22168941
Autor:
Kimie Tanaka, Kohsuke Yoshida, Shunichi Shiozawa, Masaru Mizuhara, Yoshitake Konishi, Hitomi Kitamura, Koichiro Komai, Akira Hashiramoto, Hiroki Kawasaki, Ken Tsumiyama, Koichi Murayama, Toshio Shiotsuki, Tomoatsu Kimura, Hideo Yagita, Kazuko Shiozawa
Publikováno v:
The Journal of Biological Chemistry
Rheumatoid arthritis (RA) is a chronic polyarthritis of unknown etiology. To unravel the molecular mechanisms in RA, we performed targeted DNA sequencing analysis of patients with RA. This analysis identified a variant of the death receptor 3 (DR3) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af28cc91ea5af1bc825fefe075a2fe61
http://europepmc.org/articles/PMC5808757
http://europepmc.org/articles/PMC5808757
Autor:
Nao Shibanuma, Yuto Oketani, Kenta Kaneshiro, Yoshitada Sakai, Yoshiko Kawasaki, Teppei Hashimoto, Akira Hashiramoto, Ikumi Okumura, Kanta Morii, Arisa Yaekura, Koto Uchida, Kohsuke Yoshida
Publikováno v:
Modern rheumatology. 30(2)
Objectives: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning stiffness of joints or increased production of cytokines around midnight. Clock genes have been reported to affect on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9508f400ba509381d8e0c540a09090
https://pubmed.ncbi.nlm.nih.gov/30942638
https://pubmed.ncbi.nlm.nih.gov/30942638
Autor:
Yuto Oketani, Kenta Kaneshiro, Arisa Yaekura, Yoshitada Sakai, Kanta Morii, Nao Shibanuma, Ikumi Okumura, Kohsuke Yoshida, Akira Hashiramoto
Publikováno v:
International Immunopharmacology. 84:106549
Objective Diurnal variation of symptoms are observed in rheumatoid arthritis, especially in productions of cytokines that show peak concentrations during mid night. In contrast, cytokines of collagen-induced arthritis (CIA) mice increase in daytimes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af42cd82492edb9ae853d166cb82763
http://www.lib.kobe-u.ac.jp/handle_kernel/90007284
http://www.lib.kobe-u.ac.jp/handle_kernel/90007284