Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kohsuke Minamisawa"'
Autor:
Kouta Aoyama, Shun Ito, Masaaki Miyakawa, Kouichi Tamura, Nobumichi Saito, Tomoya Umezono, Shinichi Umezawa, Toshimasa Hishiki, Fuyuki Minagawa, Hareaki Yamamoto, Masao Toyoda, Daisuke Suzuki, Kazuo Kobayashi, Keiichi Chin, Masahiro Takihata, Togo Aoyama, Kazuyoshi Sato, Hiroshi Takeda, Hideo Machimura, Yutaka Hatori, Hisakazu Degawa, Takayuki Furuki, Kohsuke Minamisawa, Masahiro Hayashi, Yoshiro Hamada, Hiroyuki Sakai, Yoshiro Suzuki, Tomohiko Kanaoka, Akira Kanamori, Nobuo Hatori
Publikováno v:
Diabetes Technology & Therapeutics. 23:110-119
Aim: Sodium–glucose cotransporter 2 inhibitors (SGLT2is) provide renal protection in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to elucidate the renal effects of long-...
Autor:
Hareaki Yamamoto, Akira Kanamori, Daisuke Suzuki, Masao Toyoda, Nobuo Hatori, Hisakazu Degawa, Kazuyoshi Sato, Takayuki Furuki, Hiroyuki Sakai, Kouta Aoyama, Kouichi Tamura, Keiichi Chin, Masahiro Takihata, Shun Ito, Fuyuki Minagawa, Masahiro Hayashi, Toshimasa Hishiki, Kohsuke Minamisawa, Yoshiro Suzuki, Hiroshi Takeda, Togo Aoyama, Hideo Machimura, Yutaka Hatori, Shinichi Umezawa, Masaaki Miyakawa, Yoshiro Hamada, Tomoya Umezono, Kazuo Kobayashi
Publikováno v:
Journal of Diabetes Investigation
Aims/Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve renal outcome in patients with type 2 diabetes mellitus, but the mechanism is not fully understood. The aim of this retrospective study was to assess the association of ac
Autor:
Kohsuke MINAMISAWA
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 39:163-166
Autor:
Hiroshi Shionoiri, Izumi Takasaki, Kunihiro Sasahara, Kumiko Konno, Hitoshi Ishizuka, Hideo Naganuma, Yukinori Kawahara, Kohsuke Minamisawa
Publikováno v:
Hypertension Research. 24:235-240
Trandolapril is the prodrug of an angiotensin-converting enzyme (ACE) inhibitor. It has been proposed that its active metabolite, trandolaprilat, is mainly excreted in bile, but this has not been clearly demonstrated. Recently it has been reported th
Autor:
Henry L. Elliott, John R. Petrie, Thomas E. Hilditch, Kohsuke Minamisawa, Andrew D. Morris, John M. C. Connell, Michael Small
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:1552-1557
Dietary sodium restriction has a variety of effects on metabolism, including activation of the renin-angiotensin system. Angiotensin II has complex metabolic and cardiovascular effects, and these may be relevant to the effects of both nonpharmacologi
Autor:
Gen Yasuda, Hideo Himeno, Kunihiko Shindo, Masahiko Naruse, Isao Nagamochi, Hiroshi Shionoiri, Shinichro Ueda, Seiji Hiroto, Izumi Takasaki, Kohsuke Minamisawa, Koichi Sugimoto, Minoru Kihara
Publikováno v:
The Journal of Clinical Pharmacology. 38:442-446
This study was conducted to examine whether imidaprilat, an active diacid of the angiotensin-converting enzyme (ACE) inhibitor imidapril, preferentially inhibits angiotensin I degradation rather than bradykinin degradation, and whether imidapril is l
Autor:
Masahiko Naruse, Seiji Hiroto, Hiroshi Shionoiri, Shinichiro Ueda, Hideo Himeno, Kohsuke Minamisawa, Izumi Takasaki
Publikováno v:
Clinical Pharmacokinetics. 32:460-480
Fosinopril is a phosphorus-containing ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor. It is hydrolysed mainly in the gastrointestinal mucosa and liver to the active diacid, fosinoprilat, which has unique pharmacological properties.
Autor:
Yoshiyuki Toya, Nobuhito Hirawa, Yoshihiro Ishikawa, Satoshi Umemura, Gen Yasuda, Kohsuke Minamisawa, Shuichi Hayashi, Masao Ishii
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 20:523-526
1. The localization of alpha-adrenoceptors in the plasma membranes of human kidney were investigated by radioligand binding, using an alpha 1-antagonist, [3H]-bunazosin, and an alpha 2-antagonist, [3H]-rauwolscine. 2. Both the maximum binding (Bmax)
Publikováno v:
Journal of the Autonomic Nervous System. 42:171-175
To determine whether sympathetic nerve activity is altered in hyperthyroidism and hypothyroidism we microneurographically measured muscle sympathetic nerve activity in patients with these thyroid dysfunctions and compared the results with those of no
Publikováno v:
Hypertension Research. 15:163-169
The systolic and diastolic blood pressures (BP) measured by the conventional auscultatory method tend to be lower and higher respectively than the corresponding values obtained with invasive direct measurement. This study aims to develop a new, nonin