Výsledky vyhledávání - "Kohshi Kusumoto"

Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis

Autor: Keiichiro Okuhira, Masahiro Ueda, Sayuki Arii, Chiaki Komiya, Kohshi Kusumoto, Masaya Denda, Akira Otaka, Akira Shigenaga

Publikováno v: Chemical and Pharmaceutical Bulletin. 68:1226-1232

Proteins incorporating artificial moieties such as fluorophores and drugs have enjoyed increasing use in chemical biology and drug development research. Preparation of such artificial protein derivatives has relied mainly on native chemical ligation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fe82bc6bad4245b401156305f4332f
https://doi.org/10.1248/cpb.c20-00674

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FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages

Autor: Koki Tachibana, Kohshi Kusumoto, Mai Ogawa, Hidenori Ando, Taro Shimizu, Yu Ishima, Tatsuhiro Ishida, Keiichiro Okuhira

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14617

Formation of foam cells as a result of excess lipid accumulation by macrophages is a pathological hallmark of atherosclerosis. Fingolimod (FTY720) is an immunosuppressive agent used in clinical settings for the treatment of multiple sclerosis and has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38efa46e64fcfa33685dbfbb59cbe2b
https://doi.org/10.3390/ijms232314617

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Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment

Autor: Tatsuhiro Ishida, Victor Tuan Giam Chuang, Masaki Otagiri, Hiroshi Morioka, Keiichiro Okuhira, Yoshiaki Suwa, Yu Ishima, Toru Maruyama, Tetsuya Fukuda, Hiroshi Watanabe, Kohshi Kusumoto, Ai Mimono

Publikováno v: IUBMB lifeREFERENCES. 72(4)

Deposition of amyloid protein, particularly Aβ1-42 , is a major contributor to the onset of Alzheimer's disease (AD). However, almost no deposition of Aβ in the peripheral tissues could be found. Human serum albumin (HSA), the most abundant protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6100d9aa560df420ca5425aa052bce
https://pubmed.ncbi.nlm.nih.gov/31794135

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