Increased TP53 somatic evolution in peritoneal washes of individuals with BRCA1 germline mutations.

Autor: Tee XR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA., Hazard E; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA., Latorre-Esteves E; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA., Ghezelayagh TS; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA; Department of Obstetrics and Gynecology, University of Washington, Seattle, USA., Fredrickson JU; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA., Coombes C; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA., Radke MR; Department of Obstetrics and Gynecology, University of Washington, Seattle, USA., Manhardt E; Department of Obstetrics and Gynecology, University of Washington, Seattle, USA., Katz R; Department of Obstetrics and Gynecology, University of Washington, Seattle, USA., Soong TR; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Swisher EM; Department of Obstetrics and Gynecology, University of Washington, Seattle, USA., Norquist BM; Department of Obstetrics and Gynecology, University of Washington, Seattle, USA., Risques RA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA. Electronic address: rrisques@uw.edu.

Publikováno v: Gynecologic oncology [Gynecol Oncol] 2024 Nov; Vol. 190, pp. 18-27. Date of Electronic Publication: 2024 Aug 10.

TP53 somatic evolution in cervical liquid-based cytology and blood from individuals with and without ovarian cancer and BRCA1 or BRCA2 germline mutations.

Autor: Ghezelayagh TS; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA.; Department of Obstetrics & Gynecology, Stanford University, Palo Alto, CA, USA., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Fredrickson J; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Krimmel-Morrison JD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Latorre-Esteves E; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Tee XR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Radke MR; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA., Manhardt E; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA., Norquist BM; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA., Katz R; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA., Swisher EM; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA., Risques RA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. rrisques@uw.edu.

Publikováno v: Oncogene [Oncogene] 2024 Jul; Vol. 43 (31), pp. 2421-2430. Date of Electronic Publication: 2024 Jun 25.

Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence.

Autor: Bradley CC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Baylor College of Medicine Medical Scientist Training Program, Houston, TX, USA.; Robert and Janice McNair Foundation/ McNair Medical Institute M.D./Ph.D. Scholars program, Houston, TX, USA., Wang C; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Gordon AJE; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Wen AX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Baylor College of Medicine Medical Scientist Training Program, Houston, TX, USA.; Robert and Janice McNair Foundation/ McNair Medical Institute M.D./Ph.D. Scholars program, Houston, TX, USA., Luna PN; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Cooke MB; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Avadhanula V; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA., Piedra PA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA., Lichtarge O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA., Shaw CA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Ronca SE; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.; Feigin Biosafety Level 3 Facility, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Department of Pediatrics Tropical Medicine, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA., Herman C; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. herman@bcm.edu.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. herman@bcm.edu.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA. herman@bcm.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 May; Vol. 9 (5), pp. 1382-1392. Date of Electronic Publication: 2024 Apr 22.

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.

Autor: Sanchez-Contreras M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Sweetwyne MT; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Tsantilas KA; Department of Biochemistry, University of Washington, Seattle, United States., Whitson JA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Campbell MD; Department of Radiology, University of Washington, Seattle, United States., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Kim HJ; Department of Biology, University of Washington, Seattle, United States., Hipp MJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Fredrickson J; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Nguyen MM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Hurley JB; Department of Biochemistry, University of Washington, Seattle, United States., Marcinek DJ; Department of Radiology, University of Washington, Seattle, United States., Rabinovitch PS; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States., Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States.

Publikováno v: ELife [Elife] 2023 Feb 17; Vol. 12. Date of Electronic Publication: 2023 Feb 17.

Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans.

Autor: Leuthner TC; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Benzing L; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Bergemann CM; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Hipp MJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Hershberger KA; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Mello DF; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Sokolskyi T; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Stevenson K; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Merutka IR; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Seay SA; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA., Gregory SG; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.; Department of Neurology, Duke University, Durham, NC 27708, USA., Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Meyer JN; Nicholas School of the Environment, Duke University, Durham, NC 27708, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Aug 26; Vol. 50 (15), pp. 8626-8642.