Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kohl T. Kinning"'
Autor:
Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114599- (2024)
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions. Hypoxemia and dysregulated hematopoiesis have been doc
Externí odkaz:
https://doaj.org/article/899484d6d7604ee5ad8c1bd6d67a98fd
Autor:
Matthew D Galbraith, Kohl T Kinning, Kelly D Sullivan, Ryan Baxter, Paula Araya, Kimberly R Jordan, Seth Russell, Keith P Smith, Ross E Granrath, Jessica R Shaw, Monika Dzieciatkowska, Tusharkanti Ghosh, Andrew A Monte, Angelo D'Alessandro, Kirk C Hansen, Tellen D Benett, Elena WY Hsieh, Joaquín M Espinosa
Publikováno v:
eLife, Vol 10 (2021)
COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechanisms
Externí odkaz:
https://doaj.org/article/c5f457f7384b4b44a7d4aef02aa82ab3
Autor:
Belinda Enriquez-Estrada, Jessica R Shaw, Ross E Granrath, Angela L. Rachubinski, Joaquín M. Espinosa, Kohl T Kinning, L. Alexander Liggett, James DeGregori, Matthew D. Galbraith, Kelly D. Sullivan, Keith P Smith
Publikováno v:
Blood Adv
Key Points Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba59ed3e4c4b466354c8920e49213e9
https://doi.org/10.1182/bloodadvances.2020003858
https://doi.org/10.1182/bloodadvances.2020003858
Autor:
Matthew D. Galbraith, Kohl T. Kinning, Kelly D. Sullivan, Paula Araya, Keith P. Smith, Ross E. Granrath, Jessica R. Shaw, Ryan Baxter, Kimberly R. Jordan, Seth Russell, Monika Dzieciatkowska, Julie A. Reisz, Fabia Gamboni, Francesca Cendali, Tusharkanti Ghosh, Kejun Guo, Cara C. Wilson, Mario L. Santiago, Andrew A. Monte, Tellen D. Bennett, Kirk C. Hansen, Elena W. Y. Hsieh, Angelo D’Alessandro, Joaquin M. Espinosa
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The impacts of interferon (IFN) signaling on COVID-19 pathology are multiple, with both protective and harmful effects being documented. We report here a multiomics investigation of systemic IFN signaling in hospitalized COVID-19 patients, defining t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cfe4675a46c51d3ed2a429ef31c528
https://doi.org/10.1073/pnas.2116730119
https://doi.org/10.1073/pnas.2116730119
Autor:
Katherine A. Waugh, Ross Minter, Jessica Baxter, Congwu Chi, Kathryn D. Tuttle, Neetha P. Eduthan, Matthew D. Galbraith, Kohl T. Kinning, Zdenek Andrysik, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael Ludwig, Kyndal A. Schade, Dayna Tracy, Keith P. Smith, Ross E. Granrath, Nicolas Busquet, Santosh Khanal, Ryan D. Anderson, Liza L. Cox, Belinda Enriquez Estrada, Angela L. Rachubinski, Hannah R. Lyford, Eleanor C. Britton, David J. Orlicky, Jennifer L. Matsuda, Kunhua Song, Timothy C. Cox, Kelly D. Sullivan, Joaquin M. Espinosa
Trisomy 21 causes Down syndrome, a condition characterized by cognitive impairments, immune dysregulation, and atypical morphogenesis. Using whole blood transcriptome analysis, we demonstrate that specific overexpression of four interferon receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0537897f7410b5176b3650f94e662bc
https://doi.org/10.1101/2022.02.03.478982
https://doi.org/10.1101/2022.02.03.478982
Autor:
Paula Araya, Kohl T. Kinning, Christina Coughlan, Keith P. Smith, Ross E. Granrath, Belinda A. Enriquez-Estrada, Kayleigh Worek, Kelly D. Sullivan, Angela L. Rachubinski, Kristine Wolter-Warmerdam, Francis Hickey, Matthew D. Galbraith, Huntington Potter, Joaquin M. Espinosa
Publikováno v:
Cell Reports. 41:111883
Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by stunted growth, cognitive impairment, and increased risk of diverse neurological conditions. Although signs of lifelong neurodegeneration are well documented in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cace022913ebac56cf21c4de08d6ef9
https://doi.org/10.1016/j.celrep.2022.111883
https://doi.org/10.1016/j.celrep.2022.111883
Autor:
Matthew D. Galbraith, Kohl T. Kinning, Kelly D. Sullivan, Paula Araya, Keith P. Smith, Ross E. Granrath, Jessica R. Shaw, Ryan Baxter, Kimberly R. Jordan, Seth Russell, Monika Dzieciatkowska, Julie A. Reisz, Fabia Gamboni, Francesca Cendali, Tusharkanti Ghosh, Andrew A. Monte, Tellen D. Bennett, Kirk C. Hansen, Elena W.Y. Hsieh, Angelo D’Alessandro, Joaquin M. Espinosa
The impacts of IFN signaling on COVID19 pathology are multiple, with protective and harmful effects being documented. We report here a multi-omics investigation of IFN signaling in hospitalized COVID19 patients, defining the biosignatures associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7745977bfd01b537a8d0c90ccaa7941
https://doi.org/10.1101/2021.07.29.21261325
https://doi.org/10.1101/2021.07.29.21261325
Autor:
Keith P Smith, Fabia Gamboni, Angelo D'Alessandro, Nik Levinsky, Seth Russell, Tusharkanti Ghosh, Julie A. Reisz, Matthew D. Galbraith, Tellen D. Bennett, Jessica R Shaw, Kimberly R. Jordan, Monika Dzieciatkowska, Francesca Cendali, Kyle Bartsch, Andrew A. Monte, Kirk C. Hansen, Elena W Y Hsieh, Paula Araya, Ross E Granrath, Kelly D. Sullivan, Michael G. Miller, Ryan Baxter, Joaquín M. Espinosa, Kohl T Kinning
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
Cell Reports
article-version (status) pre
article-version (number) 1
Cell Reports
COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. To expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients, including matched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3b66441d35064d46be4398f25cca9b
https://doi.org/10.1101/2021.03.04.21252945
https://doi.org/10.1101/2021.03.04.21252945
Autor:
Angelo D'Alessandro, Paula Araya, Tusharkanti Ghosh, Keith P Smith, Matthew D. Galbraith, Seth Russell, Tellen D. Bennett, Elena W Y Hsieh, Monika Dzieciatkowska, Kimberly R. Jordan, Andrew A. Monte, Ross E Granrath, Ryan Baxter, Joaquín M. Espinosa, Kohl T Kinning, Jessica R Shaw, Kelly D. Sullivan, Kirk C. Hansen
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
COVID19 is a heterogeneous medical condition involving a suite of underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ace00f55379845ac0d11b40a8545764
https://elifesciences.org/articles/65508
https://elifesciences.org/articles/65508
Autor:
Tusharkanti Ghosh, Matthew D. Galbraith, Ross E Granrath, Kirk C. Hansen, Ryan Baxter, Jessica R Shaw, Joaquín M. Espinosa, Kohl T Kinning, Angelo D'Alessandro, Seth Russell, Keith P Smith, Monika Dzieciatkowska, Kimberly R. Jordan, Andrew A. Monte, Tellen D Benett, Paula Araya, Elena W Y Hsieh, Kelly D. Sullivan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afa9930e3156da4fe769b80229881c1b
https://doi.org/10.7554/elife.65508.sa2
https://doi.org/10.7554/elife.65508.sa2