Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models

Autor: Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Ryotaro Asano, Huiling Jin, Connie P. C. Ow, Daryl O. Schwenke, Rajesh Katare, Kohki Aoyama, Keiji Umetani, Masato Hoshino, Kentaro Uesugi, Mikiyasu Shirai, Takeshi Ogo, James T. Pearson

Publikováno v: Frontiers in Physiology, Vol 12 (2022)

The majority of the conventional techniques that are utilized for investigating the pathogenesis of cardiovascular disease in preclinical animal models do not permit microlevel assessment of in situ cardiomyocyte and microvascular functions. Therefor

Externí odkaz: https://doaj.org/article/5f3e04a479a54aa39041018ef0af2c15

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Autor: Takeshi Ogo, Walter Paulus, Shahrooz Gaderi, Takashi Sonobe, Sarabjit S. Hansra, Mikiyasu Shirai, Darren J. Kelly, Keiji Umetani, Yi Ching Chen, Melissa Herwig, Daryl O. Schwenke, Amanda J. Edgley, James T. Pearson, Mark T. Waddingham, Vijayakumar Sukumaran, Kohki Aoyama, Andreas Mügge, Nazha Hamdani, Naoto Yagi, Detmar Kolijn, Hirotsugu Tsuchimochi

Publikováno v: Waddingham, M T, Sonobe, T, Tsuchimochi, H, Edgley, A J, Sukumaran, V, Chen, Y C, Hansra, S S, Schwenke, D O, Umetani, K, Aoyama, K, Yagi, N, Kelly, D J, Gaderi, S, Herwig, M, Kolijn, D, Mügge, A, Paulus, W J, Ogo, T, Shirai, M, Hamdani, N & Pearson, J T 2019, ' Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model ', Journal of Molecular and Cellular Cardiology, vol. 137, pp. 119-131 . https://doi.org/10.1016/j.yjmcc.2019.10.005
Journal of Molecular and Cellular Cardiology, 137, 119-131. Academic Press Inc.

Coronary microvessel endothelial dysfunction and nitric oxide (NO) depletion contribute to elevated passive tension of cardiomyocytes, diastolic dysfunction and predispose the heart to heart failure with preserved ejection fraction. We examined if di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9dff0e2b0ab192649f2441bc423abb
https://research.vumc.nl/en/publications/c7bc9c49-37e6-42cc-9e8d-7b434bee10a7

Construction and Commissioning of A 248 m-long Beamline with X-ray Undulator Light Source

Autor: Tomoki Fukui, Yasuhide Ishizawa, Yukito Furukawa, Yoshio Suzuki, Shunji Goto, Sunao Takahashi, Kohki Aoyama, Tetsuro Mochizuki, Tomohiro Matsushita, Hideo Kitamura, Haruhiko Ohashi, Naoki Takimoto, Tohru Ohata, Akihisa Takeuchi, Naoto Yagi, Hidekazu Takano, Takashi Tanaka, Makina Yabashi, Kentaro Uesugi, Hiroshi Yamazaki, Kunikazu Takeshita, Tetsuya Ishikawa

Publikováno v: AIP Conference Proceedings.

A medium‐length beamline with undulator source, BL20XU at SPring‐8, was constructed, and opened to public use. The distance from source point to the end of the beamline is 248 m. By utilizing the long beam transport path, the beamline has advanta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c501d8acd821bb78d39f3c96a80fad7
https://doi.org/10.1063/1.1757804

Production of high levels of interleukin 1-like activity by the SPI-802 human leukemia cell line with E receptors

Autor: Yukiaki Miyagawa, Kohki Aoyama, Taro Akabane, Yoshio Uehara, Atsushi Komiyama

Publikováno v: Cellular immunology. 89(1)

The SPI-802 human leukemia cell line, which possesses E receptors and used to have natural killer activity, has been demonstrated to produce high levels of interleukin 1 (IL-1)-like activity. SPI-802 supernatants prepared in 1% serum-containing cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583cd90dffc13fff56c370fbb5f115d4
https://pubmed.ncbi.nlm.nih.gov/6333284

T lymphocytotoxic human fetal antibody (TLFA) can induce the maternal and fetal lymphocytes to produce interleukin 2 and B cell growthing factor

Autor: Yukiaki Miyagawa, Kohki Aoyama

Publikováno v: Journal of Reproductive Immunology. 5:42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ff3c85c66c1bbfb9e81e3fcd3ddb059
https://doi.org/10.1016/0165-0378(83)90098-0