Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Kohji Takei"'
Autor:
Hiroshi Yamada, Hirona Osaka, Nanami Tatsumi, Miu Araki, Tadashi Abe, Keiko Kaihara, Ken Takahashi, Eizo Takashima, Takayuki Uchihashi, Keiji Naruse, Kohji Takei
Publikováno v:
Cells, Vol 13, Iss 16, p 1373 (2024)
Synaptopodin 2-like protein (SYNPO2L) is localized in the sarcomere of cardiomyocytes and is involved in heart morphogenesis. However, the molecular function of SYNPO2L in the heart is not fully understood. We investigated the interaction of SYNPO2L
Externí odkaz:
https://doaj.org/article/570279c83c264baa88c1c0f40c45be59
Autor:
Hiroshi Yamada, Tadashi Abe, Hikaru Nagaoka, Eizo Takashima, Ryo Nitta, Masahiro Yamamoto, Kohji Takei
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Irgb6 is a member of interferon γ-induced immunity related GTPase (IRG), and one of twenty “effector” IRGs, which coordinately attack parasitophorous vacuole membrane (PVM), causing death of intracellular pathogen. Although Irgb6 plays a pivotal
Externí odkaz:
https://doaj.org/article/de9b64dedb274d08bf9ed1ff95de4234
Autor:
Ayuko Sakane, Taka-aki Yano, Takayuki Uchihashi, Kazuki Horikawa, Yusuke Hara, Issei Imoto, Shusaku Kurisu, Hiroshi Yamada, Kohji Takei, Takuya Sasaki
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Sakane et al. demonstrate that JRAB/MICAL-L2, an effector protein of Rab8 and Rab13, induces endosomal tubulation in HeLa cells depending on its closed conformation caused by an activated Rab8A. JRAB/MICAL-L2 undergoes liquid-liquid phase separation
Externí odkaz:
https://doaj.org/article/7d59caf0ee0141aaa9aefc5a48b29c24
Autor:
Eriko Hamasaki, Natsuki Wakita, Hiroki Yasuoka, Hikaru Nagaoka, Masayuki Morita, Eizo Takashima, Takayuki Uchihashi, Tetsuya Takeda, Tadashi Abe, Ji-Won Lee, Tadahiro Iimura, Moin A Saleem, Naohisa Ogo, Akira Asai, Akihiro Narita, Kohji Takei, Hiroshi Yamada
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Dynamin is an endocytic protein that functions in vesicle formation by scission of invaginated membranes. Dynamin maintains the structure of foot processes in glomerular podocytes by directly and indirectly interacting with actin filaments. However,
Externí odkaz:
https://doaj.org/article/d8d684637941406b9a5dac408770ee49
Autor:
Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi
Publikováno v:
eLife, Vol 11 (2022)
Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau
Externí odkaz:
https://doaj.org/article/303a293335904bf99cca8357b822bbd8
Autor:
Tetsuya Takeda, Toshiya Kozai, Huiran Yang, Daiki Ishikuro, Kaho Seyama, Yusuke Kumagai, Tadashi Abe, Hiroshi Yamada, Takayuki Uchihashi, Toshio Ando, Kohji Takei
Publikováno v:
eLife, Vol 7 (2018)
Dynamin is a mechanochemical GTPase essential for membrane fission during clathrin-mediated endocytosis. Dynamin forms helical complexes at the neck of clathrin-coated pits and their structural changes coupled with GTP hydrolysis drive membrane fissi
Externí odkaz:
https://doaj.org/article/0b5a8c0dfbc64be19b764e78bc4766d0
Autor:
Naoto Terami, Daisuke Ogawa, Hiromi Tachibana, Takashi Hatanaka, Jun Wada, Atsuko Nakatsuka, Jun Eguchi, Chikage Sato Horiguchi, Naoko Nishii, Hiroshi Yamada, Kohji Takei, Hirofumi Makino
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100777 (2014)
Inhibition of sodium glucose cotransporter 2 (SGLT2) has been reported as a new therapeutic strategy for treating diabetes. However, the effect of SGLT2 inhibitors on the kidney is unknown. In addition, whether SGLT2 inhibitors have an anti-inflammat
Externí odkaz:
https://doaj.org/article/95f390caebe0425d811aad5116700659
Autor:
Mai Suzuki, Hirokazu Tanaka, Akira Tanimura, Kenji Tanabe, Natsuko Oe, Shinya Rai, Syunsuke Kon, Manabu Fukumoto, Kohji Takei, Takaya Abe, Itaru Matsumura, Yuzuru Kanakura, Toshio Watanabe
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31854 (2012)
Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal translocation
Externí odkaz:
https://doaj.org/article/3bd3255534ca4bedb9b619943b1874c0
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19942 (2011)
Early endosomes (EEs) are known to be a sorting station for internalized molecules destined for degradation, recycling, or other intracellular organelles. Segregation is an essential step in such sorting, but the molecular mechanism of this process r
Externí odkaz:
https://doaj.org/article/78a40f874db548d7be733a486e8ec02b
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19764 (2011)
The early endosome acts as a sorting station for internalized molecules destined for recycling or degradation. While recycled molecules are sorted and delivered to tubular endosomes, residual compartments containing molecules to be degraded undergo "
Externí odkaz:
https://doaj.org/article/c1cd3be0c01340798d5ce7bde92cd4ce