Quantitative phosphoproteomics strategies for understanding protein kinase-mediated signal transduction pathways

Autor: Hidetaka Kosako, Kohji Nagano

Publikováno v: Expert Review of Proteomics. 8:81-94

Protein phosphorylation is a central regulatory mechanism of cell signaling pathways. This highly controlled biochemical process is involved in most cellular functions, and defects in protein kinases and phosphatases have been implicated in many dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd776e02a34dbf0b9c3811f82b899028
https://doi.org/10.1586/epr.10.104

Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase

Autor: Kohji Nagano, Chiharu Itagaki, Tadaomi Takenawa, Yasushi Soda, Kenzaburo Tani, Nobuhiro Takahashi, Tomonori Izumi, Kazuto Nunomura, Toshiaki Isobe

Publikováno v: Oncogene. 25:493-502

The retinoblastoma (Rb) gene product is a tumor suppressor that is mutated or inactivated in many types of human cancers. Although Rb is known to be an upstream negative regulator of Abl protein tyrosine kinase, we propose here that Rb also functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f522717b3f3f79850ea65ab76848490b
https://doi.org/10.1038/sj.onc.1208996

Differential protein synthesis and expression levels in normal and neoplastic human prostate cells and their regulation by type I and II interferons

Autor: Alice Yang, Soren Naaby-Hansen, Kohji Nagano, Markéta J.J.M. Zvelebil, Christopher Barry Wood, John R. W. Masters, Steve Corless, Claire Hastie, Akunna Akpan, Rainer Cramer

Publikováno v: Oncogene. 23:1693-1703

Protein expression and de novo synthesis in normal and prostate cancer cell lines derived from the same patient were compared by proteomic analysis, and the effects of INFalpha and INFgamma (INF=interferon) determined. The expressions of several INF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b43c8a07122b8fc54de02e551d486a
https://doi.org/10.1038/sj.onc.1207297

Growth factor-induced promoter activation of murine phospholipase C δ4 gene

Autor: Tadaomi Takenawa, Kohji Nagano, Kei Takenaka, Kiyoko Fukami

Publikováno v: European Journal of Biochemistry. 267:28-36

Phospholipase C delta4 (PLCdelta4) is one of the delta-type PLC isozymes, the expression of which is induced in nuclei by treatment with serum and also in some cancer cells. We isolated and analyzed a promoter region of the murine PLCdelta4 gene. DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::783cb0a3e6953667c23fe9bead1fca1d
https://doi.org/10.1046/j.1432-1327.2000.00943.x

Functional Proteomic Analysis of Long-term Growth Factor Stimulation and Receptor Tyrosine Kinase Coactivation in Swiss 3T3 Fibroblasts

Autor: John F. Timms, Akunna Akpan, Steven Corless, Michael D. Waterfield, Robert Stein, Soren Naaby-Hansen, Kohji Nagano, Nick Totty, Allan Stensballe, Al Burlingame, Alice Yang, Rainer Cramer, Marketa Zvelebil, Gayathri Warnasuriya

Publikováno v: Nagano, K, Akpan, A, Warnasuriya, G, Corless, S, Totty, N, Yang, A, Stein, R, Zvelebil, M, Stensballe, A, Burlingame, A, Waterfield, M, Cramer, R, Timms, J F & Hansen, S N 2012, ' Functional Proteomic Analysis of Long-term Growth Factor Stimulation and Receptor Tyrosine Kinase Coactivation in Swiss 3T3 Fibroblasts ', Molecular and Cellular Proteomics, vol. 11, no. 12, pp. 1690-1708 . https://doi.org/10.1074/mcp.M112.019778
Molecular & cellular proteomics : MCP, vol 11, iss 12
Nagano, K, Akpan, A, Warnasuriya, G, Corless, S, Totty, N, Yang, A, Stein, R, Zvelebil, M, Stensballe, A, Burlingame, A, Waterfield, M, Cramer, R, Timms, J F & Hansen, S N 2012, ' Functional proteomic analysis of long-term growth factor stimulation and receptor tyrosine kinase coactivation in Swiss 3T3 fibroblasts ', Molecular and Cellular Proteomics, vol. 11, no. 12, pp. 1690-708 . https://doi.org/10.1074/mcp.M112.019778

In Swiss 3T3 fibroblasts, long-term stimulation with PDGF, but not insulin-like growth factor 1 (IGF-1) or EGF, results in the establishment of an elongated migratory phenotype, characterized by the formation of retractile dendritic protrusions and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c5bd930df46f46686b85742fa66e24
https://vbn.aau.dk/da/publications/7f0475bf-ed74-4525-a8dd-3c94ca0e05e0