Výsledky vyhledávání - "Kohji KUROYANAGI"

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF PACLITAXEL (I) : Intravenous administration to rats prior to and in the early stages of pregnancy

Autor: Shuichi KAI, Hisashi KOHMURA, Eiko HIRAIWA, Shigeru KOIZUMI, Katsumi ISHIKAWA, Shigeo KAWANO, Kohji KUROYANAGI, Norimichi HATTORI, Hirotaka CHIKAZAWA, Hiroshi KONDOH, Kayo SAKAKURA, Toshihito KADOTA, Norimitsu TAKAHASHI

Publikováno v: The Journal of Toxicological Sciences. 19:57-67

Paclitaxel, an antineoplastic agent, was administered intravenously to Crj: CD (SD) rats daily at dose levels of 0 (saline and vehicle), 0.1, 0.3 and 1.0 mg/kg for 63 days prior to mating and during the mating period in males, and for 14 days prior t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d68208d475b32bcf63e851e99257e7
https://doi.org/10.2131/jts.19.supplementi_57

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REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF PACLITAXEL (II) : Intravenous administration to rats during the fetal organogenesis

Autor: Shuichi Kai, Eiko Hiraiwa, Kayo Sakakura, Kohji Kuroyanagi, Hiroshi Kondoh, Hirotaka Chikazawa, Norimichi Hattori, Katsumi Ishikawa, Shigeo Kawano, Toshihito Kadota, Hisashi Kohmura, Norimitsu Takahashi, Shigeru Koizumi

Publikováno v: The Journal of Toxicological Sciences. 19:69-91

Paclitaxel, an antineoplastic agent, was administered intravenously to pregnant Crj: CD (SD) rats daily at dose levels of 0 (saline and vehicle), 0.15, 0.3 and 0.6 mg/kg from day 7 to day 17 of gestation. Results were as follows: 1. The ossification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cab70ea2d27bf986fa88e167242052
https://doi.org/10.2131/jts.19.supplementi_69

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TOXICITY STUDIES OF PACLITAXEL (I) : Single dose intravenous toxicity in rats

Autor: Eiko Hiraiwa, Shigeo Kawano, Kohji Kuroyanagi, Kayo Sakakura, Norimichi Hattori, Norimitsu Takahashi, Katsumi Ishikawa, Shigeru Koizumi, Toshihito Kadota, Hirotaka Chikazawa, Hiroshi Kondoh, Hisashi Kohmura

Publikováno v: The Journal of Toxicological Sciences. 19:1-9

Paclitaxel, an antineoplastic agent, was given to Crj: CD (SD) rats of both sexes at 38, 50, 65 and 85 mg/kg by single intravenous administration to investigate its acute toxicity. The results obtained are summarized as follows: 1. Tachypnea and decr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ff550a200351aaad4d05fb65e95493
https://doi.org/10.2131/jts.19.supplementi_1

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TOXICITY STUDIES OF PACLITAXEL (II) : One-month intermittent intravenous toxicity in rats

Autor: Toshihito KADOTA, Hirotaka CHIKAZAWA, Hiroshi KONDOH, Katsumi ISHIKAWA, Shigeo KAWANO, Kohji KUROYANAGI, Norimichi HATTORI, Kayo SAKAKURA, Shigeru KOIZUMI, Eiko HIRAIWA, Hisashi KOHMURA, Shuichi KAI, Norimitsu TAKAHASHI

Publikováno v: The Journal of Toxicological Sciences. 19:11-34

Paclitaxel, an antineoplastic agent, was intravenously given to Crj:CD (SD) rats of both sexes at 0 (saline), 0 (vehicle), 1.0 (low dose), 3.3 (intermediate dose) and 10.0 (high dose) mg/kg at five-day interval over one-month period (6 times in total

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900dc53d56be7f04b2a988702a2d2b51
https://doi.org/10.2131/jts.19.supplementi_11

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TOXICITY STUDIES OF PACLITAXEL (III) : Six-month intermittent intravenous toxicity in rats

Autor: Toshihito KADOTA, Hiroshi KONDOH, Hirotaka CHIKAZAWA, Kohji KUROYANAGI, Norimiti HATTORI, Katsumi ISHIKAWA, Shigeo KAWANO, Kayo SAKAKURA, Shigeru KOIZUMI, Eiko HIRAIWA, Shinji HISADA, Shuichi KAI, Hisashi KOHMURA, Norimitsu TAKAHASHI

Publikováno v: The Journal of Toxicological Sciences. 19:35-55

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841d7ea890a293314bca2b1633912f52
https://doi.org/10.2131/jts.19.supplementi_35

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[Reproductive and developmental toxicity studies of buspirone hydrochloride (II)--Oral administration to rats during perinatal and lactation periods]

Autor: Katsumi Ishikawa, Satoshi Ohta, Shigeo Kawano, Hirotaka Chikazawa, Kohji Kuroyanagi, Hiroshi Kondo, Norimitsu Takahashi, Hisashi Kohmura, Shuichi Kai, Toshihito Kadota

Publikováno v: The Journal of toxicological sciences. 15

Buspirone hydrochloride (buspirone), an anxiolytic drug, was administered orally to pregnant Crj: CD (Sprague-Dawley) rats from day 17 of gestation through day 20 of postpartum at dose levels of 2, 12 and 75 mg/kg/day. The summarized results obtained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268c7be6dbf2b803a15a336d734ae8c1
https://pubmed.ncbi.nlm.nih.gov/2376870

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[Reproductive and developmental toxicity studies of buspirone hydrochloride (I)--Oral administration to rats during the period of fetal organogenesis]

Autor: Shuichi Kai, Katsumi Ishikawa, Norimitsu Takahashi, Hirotaka Chikazawa, Shigeo Kawano, Satoshi Ohta, Hisashi Kohmura, Hiroshi Kondo, Kohji Kuroyanagi, Toshihito Kadota

Publikováno v: The Journal of toxicological sciences. 15

Buspirone hydrochloride (buspirone), an anxiolytic drug, was administered orally to pregnant Crj : CD (Sprague-Dawley) rats from day 7 through 17 of gestation at dose levels of 2, 12 and 75 mg/kg/day. The summarized results obtained are as follows :

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca5f93a84a522f8da1d40a7dec7699d
https://pubmed.ncbi.nlm.nih.gov/2376869

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REPRODUCTION STUDIES OF VP 16-213 (V) : Intravenous administration to rats prior to and in the early stages of pregnancy

Autor: Norimitsu TAKAHASHI, Shuichi KAI, Hisashi KOHMURA, Katsumi ISHIKAWA, Takashi TANAKA, Kohji KUROYANAGI, Yoshinori HAMAJIMA, Satoshi OHTA, Toshihito KADOTA, Shigeo KAWANO, Keiko OHTA, Yukako TAKEUCHI

Publikováno v: The Journal of Toxicological Sciences. 11:263-279

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered intravenously to male Crj : CD (Sprague-Dawley) rats for 61 days and to female rats of the same strain for 14 days prior to mating at dose levels of 0.05, 0.2 and 0.8 mg/kg/day.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9b25132c19aec5948942ad8b399c5
https://doi.org/10.2131/jts.11.supplementi_263

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TOXICITY STUDIES OF VP 16-213 (V) Intravenous three-month toxicity in rats

Autor: Katsumi Ishikawa, Kohji Kuroyanagi, Satoshi Ohta, Hirotaka Chikazawa, Yukako Takeuchi, Hisashi Kohmura, Norimitsu Takahashi, Toshihito Kadota, Shigeo Kawano, Keiko Ohta, Shuichi Kai, Yoshinori Hamajima

Publikováno v: The Journal of Toxicological Sciences. 11:123-161

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered intravenously to Crj : CD (Sprague-Dawley) rats of both sexes at dose levels of 0.05, 0.15, 0.5 and 1.5 mg/kg/day for three months with the object of examining its toxicity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e523f1c382b6fdc6ad6bea40fe8c25ec
https://doi.org/10.2131/jts.11.supplementi_123

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TOXICITY STUDIES OF VP 16-213 (II) : Oral one-month subacute toxicity in rats

Autor: Katsumi Ishikawa, Hisashi Kohmura, Satoshi Ohta, Yoshinori Hamajima, Keiko Ohta, Norimitsu Takahashi, Kohji Kuroyanagi, Shigeo Kawano, Shuichi Kai, Toshihito Kadota

Publikováno v: The Journal of Toxicological Sciences. 11:17-49

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered orally to Crj : CD (Sprague-Dawley) rats of both sexes at dose levels of 3, 10, 30 and 100 mg/kg/day for one month with the object of examining its subacute toxicity and the rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43602d8ea2786d35665d40d5c405150
https://doi.org/10.2131/jts.11.supplementi_17

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