Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Kohji Itoh"'
Autor:
Daisuke Tsuji, Atsushi Nakayama, Riko Yamamoto, Shuji Nagano, Takashi Taniguchi, Ryota Sato, Sangita Karanjit, Naoki Muguruma, Tetsuji Takayama, Kohji Itoh, Kosuke Namba
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Photoactive dyes can show promising cytotoxicity via reactive oxygen species generated by photoirradiation, however, the cytotoxicity of small molecule dyes is typically weak. Here, the authors develop 1,3a,6a-triazapentalene derivatives exhibiting s
Externí odkaz:
https://doaj.org/article/600a82412aef46b9870f796b42eaeb9b
Autor:
Yuto Horii, Toshiki Iniwa, Masayoshi Onitsuka, Jun Tsukimoto, Yuki Tanaka, Hironobu Ike, Yuri Fukushi, Haruna Ando, Yoshie Takeuchi, So-ichiro Nishioka, Daisuke Tsuji, Mariko Ikuo, Naoshi Yamazaki, Yoshiharu Takiguchi, Naozumi Ishimaru, Kohji Itoh
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 297-310 (2022)
Galactosialidosis (GS) is a lysosomal cathepsin A (CTSA) deficiency. It associates with a simultaneous decrease of neuraminidase 1 (NEU1) activity and sialylglycan storage. Central nervous system (CNS) symptoms reduce the quality of life of juvenile/
Externí odkaz:
https://doaj.org/article/c205affe2a714860b2af6ebf4b800e26
Autor:
Sanghoon Lee, Naonobu Tanaka, Sakura Takahashi, Daisuke Tsuji, Sang-Yong Kim, Mareshige Kojoma, Kohji Itoh, Jun’ichi Kobayashi, Yoshiki Kashiwada
Publikováno v:
Marine Drugs, Vol 18, Iss 9, p 455 (2020)
Exploration for specialized metabolites of Okinawan marine sponges Agelas spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (
Externí odkaz:
https://doaj.org/article/96a02758bdfb40f69559234f0a000b95
Autor:
Takeshi Harada, Shuji Ozaki, Asuka Oda, Daisuke Tsuji, Akishige Ikegame, Masami Iwasa, Kengo Udaka, Shiro Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Yoshiaki Kuroda, Shigeto Kawai, Kohji Itoh, Hisafumi Yamada-Okabe, Toshio Matsumoto, Masahiro Abe
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83905 (2013)
The immunomodulatory drug lenalidomide (Len) has drawn attention to potentiate antibody-dependent cellular cytotoxicity (ADCC)-mediated immunotherapies. We developed the defucosylated version (YB-AHM) of humanized monoclonal antibody against HM1.24 (
Externí odkaz:
https://doaj.org/article/00b390f60083463bad76d520e874fada
Autor:
Ayako Nakano, Daisuke Tsuji, Hirokazu Miki, Qu Cui, Salah Mohamed El Sayed, Akishige Ikegame, Asuka Oda, Hiroe Amou, Shingen Nakamura, Takeshi Harada, Shiro Fujii, Kumiko Kagawa, Kyoko Takeuchi, Akira Sakai, Shuji Ozaki, Kazuma Okano, Takahiro Nakamura, Kohji Itoh, Toshio Matsumoto, Masahiro Abe
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27222 (2011)
Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps. Because cancer cells produce ATP mostly through glycolysis, in the present study we explored t
Externí odkaz:
https://doaj.org/article/1371243487bd4862b795ae3496a1cf00
Autor:
Takashi Kodama, Tadayasu Togawa, Takahiro Tsukimura, Ikuo Kawashima, Kazuhiko Matsuoka, Keisuke Kitakaze, Daisuke Tsuji, Kohji Itoh, Yo-Ichi Ishida, Minoru Suzuki, Toshihiro Suzuki, Hitoshi Sakuraba
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29074 (2011)
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexos
Externí odkaz:
https://doaj.org/article/8a1281c4473f400db85b8e7bfd12c6fd
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16269 (2011)
BACKGROUND: Sandhoff disease (SD) is a neurodegenerative lysosomal β-hexosaminidase (Hex) deficiency involving excessive accumulation of undegraded substrates, including terminal GlcNAc-oligosaccharides and GM2 ganglioside. Microglia-mediated neuroi
Externí odkaz:
https://doaj.org/article/ff9a5d1b96b849989d894da81c9d92e9
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1609-1615
Publikováno v:
Journal of Natural Medicines. 77:173-179
Three new farnesylated coumarins, communiferulins A-C (1-3), and a farnesylated chromone, ferchromone (4), were isolated from the roots of an Apiaceous plant Ferula communis. Their structures including the relative configurations were elucidated by a
Autor:
Hiroki Tanaka, Daisuke Tsuji, Ryosuke Watanabe, Yukiya Ohnishi, Shindai Kitaguchi, Ryuto Nakae, Hiromi Teramoto, Jun Tsukimoto, Yuto Horii, Kohji Itoh
Publikováno v:
Journal of Inherited Metabolic Disease. 45:1191-1202
Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by genetic defects in lysosomal enzymes or related factors. LSDs are associated with excessive accumulation of natural substrates in lysosomes leading to central nervous syste