Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Kohji Hanasaki"'
Autor:
Kohji Nomura, Akemi Nakamura, Norito Yoshimura, Masayuki Sugimoto, Takanori Iwasaki, Midori Kojima, Kohji Hanasaki, Keita Fukao, Toru Nakano, Ken-Ichiro Uwabe, Seijiro Hara, Tadateru Hamada, Toshihiro Shinosaki, Noriyuki Naya, Keiichi Imagawa
Publikováno v:
Metabolism. 65:16-25
Objective Although peroxisome proliferator-activated receptor (PPAR) δ agonists have been shown to improve the serum lipoprotein profiles in humans, the impact of the changes in these lipoprotein profiles on atherosclerosis remains to be elucidated.
Autor:
Keiichi Imagawa, Kohji Hanasaki, Nobuteru Akiyama, Takashi Ono, Takayuki Kuroda, Toshihiro Shinosaki, Toshihiko Murayama, Yuko Akiyama, Kenji Asakura, Hideaki Kato
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:66-74
Signals from intracellular glucocorticoids (GCs) via 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in adipose tissues have been reported to serve as amplifiers leading to deterioration of glucose metabolism associated with obesity. To elucidat
Autor:
Kazuhiro Watanabe, Kiyotaka Kugiyama, Yosuke Watanabe, Ken-ichi Kawabata, Shun Tamaru, Soichiro Takahashi, Takamitsu Nakamura, Hideto Mishina, Daisuke Fujioka, Koji Suzuki, Jun-ei Obata, Makoto Murakami, Yasunori Yokota, Kohji Hanasaki
Publikováno v:
The Journal of Immunology. 191:1021-1028
Secretory phospholipase A2 (sPLA2) plays a critical role in the genesis of lung inflammation through proinflammatory eicosanoids. A previous in vitro experiment showed a possible role of cell surface receptor for sPLA2 (PLA2R) in the clearance of ext
Autor:
Nobuo Chomei, Ken-ichi Kusakabe, Masahiro Sakagami, Kohji Hanasaki, Hiroshi Hamana, Yasuyoshi Iso, Satomi Shinonome, Yukio Tada, Keiko Kawamoto, Hideyuki Takenaka, Kiyoshi Yasui, Yasuhide Morioka
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2045-2055
Selective CB2 agonists have the potential for treating pain without central CB1-mediated adverse effects. Screening efforts identified 1,2-dihydro-3-isoquinolone 1; however, this compound has the drawbacks of being difficult to synthesize with two as
Autor:
Yoshikazu Ishimoto, Yuki Isogai, Kohji Hanasaki, Shuntaro Hara, Makoto Murakami, Noriko Suzuki, Yoshitaka Taketomi, Yukio Ishikawa, Seiko Masuda, Yasunori Yokota, Kazutaka Ikeda, Hiroyasu Sato, Kei Yamamoto, Yoshimi Miki, Daisuke Kamei, Toshiharu Ishii, Ryo Taguchi, Toshiko Suzuki-Yamamoto, Tetsuyuki Kobayashi
Publikováno v:
Journal of Biological Chemistry. 286:11632-11648
Although the secreted phospholipase A(2) (sPLA(2)) family has been generally thought to participate in pathologic events such as inflammation and atherosclerosis, relatively high and constitutive expression of group X sPLA(2) (sPLA(2)-X) in restricte
Autor:
Yoshitaka Taketomi, Hiroki Nakanishi, Toshiharu Ishii, Yoshimi Miki, Yoshikazu Ishimoto, Yukio Ishikawa, Kazutaka Ikeda, Kiyoko Fukami, Yuki Isogai, Noriko Suzuki, Yasumasa Nishito, Kohji Hanasaki, Makoto Murakami, Kei Yamamoto, Tetsuyuki Kobayashi, Seiko Masuda, Ryo Taguchi, Yasunori Yokota, Kiyokazu Morioka, Hiroyasu Sato
Publikováno v:
Journal of Biological Chemistry. 286:11616-11631
Although perturbed lipid metabolism can often lead to skin abnormality, the role of phospholipase A(2) (PLA(2)) in skin homeostasis is poorly understood. In the present study we found that group X-secreted PLA(2) (sPLA(2)-X) was expressed in the oute
Autor:
Kohji Hanasaki, Yuko Akiyama, Kenzo Funatsuki, Kenji Asakura, Mitsuru Notoya, Nobuteru Akiyama, Toru Yanagimoto, Tatsuo Kobayashi, Hideaki Katoh, Sachiko Yamamoto, Toshihiro Shinosaki
Publikováno v:
European Journal of Pharmacology. 649:23-28
Irbesartan, an angiotensin II type 1 receptor blocker has been reported to alleviate metabolic disorder in animal studies and human clinical trials. Although this effect may be related to the ability of irbesartan to serve as a partial agonist for th
Autor:
Hideo Tezuka, Masaki Kanazawa, Kiyotaka Kugiyama, Yoshikazu Ishimoto, Toshiaki Yano, Takamitsu Nakamura, Ken-ichi Kawabata, Tsuyoshi Kobayashi, Kohji Hanasaki, Yukio Saito, Yasunori Yokota, Noriko Suzuki, Jyun-ei Obata, Daisuke Fujioka
Publikováno v:
Circulation. 117:2977-2985
Background— Group X secretory phospholipase A 2 (sPLA 2 -X) has the most potent hydrolyzing activity toward phosphatidylcholine and elicits a marked release of arachidonic acid among several types of sPLA 2 . sPLA 2 -X is expressed in neutrophils,
Publikováno v:
Analytical Letters. 39:957-972
A liquid chromatography/mass spectrometry method using two internal standards was developed for the simultaneous quantitative determination of phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylcholine (P
Autor:
Takao Shimizu, Yoshikazu Ishimoto, Kohji Hanasaki, Takashi Ono, Hitoshi Arita, Kaoru Seno, Naonori Uozumi, Akihiko Saiga
Publikováno v:
Prostaglandins & Other Lipid Mediators. 75:79-89
Group X secretory phospholipase A2 (sPLA2-X) and cytosolic phospholipase A2 alpha (cPLA2alpha) are involved in the release of arachidonic acid (AA) from membrane phospholipids linked to the eicosanoid production in various pathological states. Recent