Zobrazeno 1 - 10 of 275 pro vyhledávání: '"Kohji Seio"'
1
Akademický článek
Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo
Autor: Masahito Noguchi, Aya Miyauchi, Yoshiaki Masaki, Masashi Sakaki, Xiao-Feng Lei, Momoko Kobayashi-Tanabe, Akira Miyazaki, Takeshi Aoki, Hitoshi Yoshida, Kohji Seio, Joo-ri Kim-Kaneyama
Publikováno v: JHEP Reports, Vol 6, Iss 11, Pp 101195- (2024)
Background & Aims: Chronic liver diseases, including metabolic dysfunction-associated steatohepatitis (MASH), pose a significant global health burden. Progressive liver fibrosis can lead to severe outcomes; however, there is a lack of effective thera
Externí odkaz: https://doaj.org/article/1d0608e23cbc477c9c612c92c8d63df7
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2
Akademický článek
Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides
Autor: Yoshiaki Masaki, Yukiko Onishi, Kohji Seio
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Substitutions, insertions, and deletions derived from synthetic oligonucleotides are the hurdles for the synthesis of long DNA such as genomes. We quantified these synthetic errors by next-generation sequencing and revealed that the quality
Externí odkaz: https://doaj.org/article/66c7bd141b5442e0afb09bcbb6478749
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4
Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H
Autor: Yoshiaki Masaki, Ayano Tabira, Shihori Hattori, Shunsuke Wakatsuki, Kohji Seio
Publikováno v: Organicbiomolecular chemistry. 20(45)
RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs). Although various chemical modifications have been developed to regulate RNase H-mediated cleavage, precise control is yet to be achieved. In this study, we tried t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d634d569d8bb6549eaa13de55ac827f
https://pubmed.ncbi.nlm.nih.gov/36321625
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6
Transcription of DNA duplex containing deoxypseudouridine and deoxypseudoisocytidine, and inhibition of transcription by triplex forming oligonucleotide that recognizes the modified duplex
Autor: Takashi Kanamori, Kei Yamaguchi, Ayano Yamazaki, Kohji Seio, Yoshiaki Masaki
Publikováno v: Nucleosides, Nucleotides & Nucleic Acids. 39:892-904
We developed new DNA triplexes that contain four base triads T-A·T, A-ψ·CBr, G-PIC·YO, and C-G·Py+, where CBr, YO, Py, ψ, and PIC are 5-bromocytosine, 5-methyl-4-pyrimidone, 2-aminopyridine, the aglycons of deoxypseudouridine, and deoxypseudois
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5ba03af44b83280d3d06e9cad694b7
https://doi.org/10.1080/15257770.2020.1714652
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7
Synthesis of Deoxypseudouridine 5′-Triphosphate Bearing the Photoremovable Protecting Group at the N1 Position Capable of Enzymatic Incorporation to DNA
Autor: Kohji Seio, Yuji Yamada, Leo Takeshita, Yoshiaki Masaki
Publikováno v: The Journal of Organic Chemistry. 85:1861-1870
Enzymatic incorporation of deoxynucleoside 5'-triphosphate bearing the photocleavable protecting group is a useful method for the preparation of photocaged oligodeoxynucleotides. Here, we describe the synthesis of new photocaged deoxynucleoside triph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::193fef2081ecc886c915635ba73e41d2
https://doi.org/10.1021/acs.joc.9b02194
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8
Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface
Autor: Hidenori Okamura, Giang Hoang Trinh, Zhuoxin Dong, Yoshiaki Masaki, Kohji Seio, Fumi Nagatsugi
Publikováno v: Nucleic acids research. 50(6)
Unnatural base pairs (UBPs) which exhibit a selectivity against pairing with canonical nucleobases provide a powerful tool for the development of nucleic acid-based technologies. As an alternative strategy to the conventional UBP designs, which invol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f61cf6f50efc84d35b28db4c6a5491
https://pubmed.ncbi.nlm.nih.gov/35234916
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9
Akademický článek
Synthesis of Oligodeoxynucleotides Using Fully Protected Deoxynucleoside 3′-Phosphoramidite Building Blocks and Base Recognition of Oligodeoxynucleotides Incorporating N3-Cyano-Ethylthymine
Autor: Mitsuo Sekine, Kohji Seio, Hirosuke Tsunoda, Akihiro Ohkubo, Tomomi Kudo
Publikováno v: Molecules, Vol 15, Iss 11, Pp 7509-7531 (2010)
Oligodeoxynucleotide (ODN) synthesis, which avoids the formation of side products, is of great importance to biochemistry-based technology development. One side reaction of ODN synthesis is the cyanoethylation of the nucleobases. We suppressed this r
Externí odkaz: https://doaj.org/article/4cac7adf9edd4f7e82e1ad0039df0609
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10
31P NMR Study on the Reactions of Amino Acids and Sugar Derivatives with Pyrophosphorous Acid as a Possible Prebiotic Phosphonylating Agent
Autor: Yoshiaki Masaki, Takahito Tomori, Takashi Shiozawa, Kentaro Ohno, Daiki Sugiyama, Kohji Seio
Publikováno v: Bulletin of the Chemical Society of Japan. 92:905-911
Phosphorus is an essential element in living organisms. Evaluating prebiotic processes that lead to phosphorylated biomolecules is an important step toward understanding the origin of life. Schreib...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::225aab2c936a9a70650ff4c6be85b8ef
https://doi.org/10.1246/bcsj.20180392
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