Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kohichiro Yoshino"'
Autor:
Joost C M Uitdehaag, Jeroen A D M de Roos, Antoon M van Doornmalen, Martine B W Prinsen, Jos de Man, Yoshinori Tanizawa, Yusuke Kawase, Kohichiro Yoshino, Rogier C Buijsman, Guido J R Zaman
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92146 (2014)
The anti-proliferative activities of all twenty-five targeted kinase inhibitor drugs that are in clinical use were measured in two large assay panels: (1) a panel of proliferation assays of forty-four human cancer cell lines from diverse tumour tissu
Externí odkaz:
https://doaj.org/article/f0dfe06ae41c471a84f2bb2bd66742e5
Autor:
Miruto Tanaka, Shinsuke Nakamura, Tomohisa Sakaue, Takumi Yamamoto, Masashi Maekawa, Anri Nishinaka, Hiroto Yasuda, Kaori Yunoki, Yuji Sato, Masaaki Sawa, Kohichiro Yoshino, Masamitsu Shimazawa, Masahiko Hatano, Takeshi Tokuhisa, Shigeki Higashiyama, Hideaki Hara
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:927-942
Background: Endothelial cell activation is tightly controlled by the balance between VEGF (vascular endothelial cell growth factor) and Notch signaling pathway. VEGF destabilizes blood vessels and promotes neovascularization, which are common feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8e6ea50a3a87bc36ed2b747c223745
https://doi.org/10.1161/atvbaha.123.318987
https://doi.org/10.1161/atvbaha.123.318987
Autor:
Kosei Arimura, Atsuo Ozaki, Hideo Ohtsubo, Kohichiro Yoshino, Chuwa Tei, Heiichiro Hamada, Hiroshi Fujiwara, Kakushi Matsushita, Naomichi Arima, Toshimasa Kukita, Takafumi Hagiwara
Publikováno v:
European Journal of Haematology. 73:17-24
BACKGROUND AND OBJECTIVES We examined the involvement of apoptosis with myelodysplastic syndrome (MDS) accompanied by peripheral cytopenias despite normo-hypercellular bone marrow. MATERIALS AND METHODS Bone marrow smears from 31 patients with MDS-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a863aa37fe3943195e59c32efc8e810
https://doi.org/10.1111/j.1600-0609.2004.00261.x
https://doi.org/10.1111/j.1600-0609.2004.00261.x
Autor:
Shin-Ichiro Nishimura, Kohichi Yokota, Yoshimasa Inoue, Hirosato Kondo, Nobuaki Miura, Takahiro Tsukida, Hideki Moriyama, Kohichiro Yoshino
Publikováno v:
Journal of Medicinal Chemistry. 47:1930-1938
As a part of synthetic studies on MMP (matrix metalloproteinase)/ADAM (a disintegrin and metalloproteinase) inhibitors, we have preliminarily communicated that azasugar-based compound 1a exhibited a potential inhibitory activity on some metalloprotea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b139f2b2f383e58c6cde341f5a62d901
https://doi.org/10.1021/jm0304313
https://doi.org/10.1021/jm0304313
Autor:
Kohichiro Yoshino, Shin-Ichiro Nishimura, Hideki Moriyama, Yoshimasa Inoue, Takahiro Tsukida, Hirosato Kondo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2737-2740
In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9963940fc5f5e2df0676bf362146f660
https://doi.org/10.1016/s0960-894x(03)00530-4
https://doi.org/10.1016/s0960-894x(03)00530-4
Autor:
Yasuyuki Kirii, Ko Okumura, Tomomi Inoue, Kohichiro Yoshino, Yasuhiro Yoshikawa, Nobuhiko Kayagaki, Hideo Yagita, Hiroaki Shibata, Keiji Terao
Publikováno v:
Journal of Immunological Methods. 278:201-209
Fas ligand (FasL) cDNAs were cloned and sequenced from cynomolgus, rhesus, and pig-tailed monkeys. The 840-bp cDNAs were identical among these three species of monkeys except for one nucleotide. The deduced 280 amino acids were completely identical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae6a4f7bdca4025599b8b2d5754a5ba
https://doi.org/10.1016/s0022-1759(03)00187-x
https://doi.org/10.1016/s0022-1759(03)00187-x
Autor:
Koichi Yokota, Hisamichi Aizawa, Michihisa Zenmyo, Kohichiro Yoshino, Akemi Kuzuhara, Yusuke Kawase, Tomoaki Hoshino, Yu Maeda, Masanori Nakamura, Koji Hiraoka, Eiji Nishiwaki
Publikováno v:
Journal of Bone and Mineral Research. 18:975-983
The in vivo effects of IL-18 on bone metabolism were investigated by histopathology in IL-18 transgenic mice. Deformed cortical bone and decreased turnover rate of lumbar trabecular bone are consistent with increased expression of IFN-gamma and IL-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d37c793a098677f4881bdb303b9174
https://doi.org/10.1359/jbmr.2003.18.6.975
https://doi.org/10.1359/jbmr.2003.18.6.975
Autor:
Yoshinobu Koguchi, Shizuo Akira, Kazuya Miyagi, Kazuyoshi Kawakami, Kiyoshi Takeda, Yusuke Kawase, Atsushi Saito, Tomoaki Hoshino, Kaori Uezu, Kohichiro Yoshino, Masaki Okamoto, Yuki Kinjo, Koichi Yokota, Satomi Yara
Publikováno v:
The Journal of Immunology. 169:323-329
The present study was conducted to critically determine the protective role of IL-18 in host response to Mycobacterium tuberculosis infection. IL-18-deficient (knockout (KO)) mice were slightly more prone to this infection than wild-type (WT) mice. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64d8f948b1d7c5cdf2423620c4f20b8
https://doi.org/10.4049/jimmunol.169.1.323
https://doi.org/10.4049/jimmunol.169.1.323
Autor:
Yasuko Ito, Minoru Yamamoto, Masaaki Sawa, Yu Maeda, Tomomi Inoue, Etsuko Ishibushi, Ryoichi Hirayama, Eiji Nishiwaki, Yoshimasa Inoue, Kohichiro Yoshino, Yasuyuki Kirii, Kiriko Kurokawa, Tomohiro Miyasaka, Hirosato Kondo, Takao Kiyoi, Hiroshi Kumihara, Hiroshi Ohmoto
Publikováno v:
Journal of Medicinal Chemistry. 45:919-929
A series of phosphonamide-based hydroxamate derivatives were synthesized, and the inhibitory activities were evaluated against various metalloproteinases in order to clarify its selectivity profile. Among the four diastereomeric isomers resulting fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cda93ba742f3aff92e244d17d126da
https://doi.org/10.1021/jm0103211
https://doi.org/10.1021/jm0103211
Autor:
Eiji Nishiwaki, Kohichiro Yoshino, Hirohide Sawada, Tsuyoshi Yoshinaka, Hiroshi Ishiguro, Katherine Smith, Kouji Yamada, Kazuhiro Nishii, Shigeki Higashiyama
Publikováno v:
Gene. 282:227-236
The ADAM family of membrane-anchored proteins has a unique domain structure, with each containing a disintegrin and metalloprotease (ADAM) domain. We have isolated mouse and human cDNAs encoding a novel member of the ADAM family. The mouse and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6c66fb9e9b1e9a274e4c687ccc633d
https://doi.org/10.1016/s0378-1119(01)00818-6
https://doi.org/10.1016/s0378-1119(01)00818-6