Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Kohichi Tanaka"'
Autor:
Lei Xing, Vasiliki Gkini, Anni I. Nieminen, Hui-Chao Zhou, Matilde Aquilino, Ronald Naumann, Katrin Reppe, Kohichi Tanaka, Peter Carmeliet, Oskari Heikinheimo, Svante Pääbo, Wieland B. Huttner, Takashi Namba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B. During human neocortex development, ARHGAP11B increases the abundance
Externí odkaz:
https://doaj.org/article/7f5a9fcd3d7146608de6b3e645883f2f
Autor:
Kaito Onodera, Yusuke Tsuno, Yuichi Hiraoka, Kohichi Tanaka, Takashi Maejima, Michihiro Mieda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Prokineticin 2 (Prok2) is a small protein expressed in a subpopulation of neurons in the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals. Prok2 has been implicated as a candidate output molecule from the SCN to cont
Externí odkaz:
https://doaj.org/article/83436af8438343a89643f5071b6f2bfb
Autor:
Yubo Peng, Yusuke Tsuno, Ayako Matsui, Yuichi Hiraoka, Kohichi Tanaka, Shin-ichi Horike, Takiko Daikoku, Michihiro Mieda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The suprachiasmatic nucleus (SCN), the central circadian clock in mammals, is a neural network consisting of various types of GABAergic neurons, which can be differentiated by the co-expression of specific peptides such as vasoactive intestinal pepti
Externí odkaz:
https://doaj.org/article/227bbdf86a8346c6ae31893eb59452a7
Autor:
Yoshifumi Abe, Norio Takata, Yuki Sakai, Hiro Taiyo Hamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Denis Le Bihan, Kenji Doya, Kenji F Tanaka
Publikováno v:
NeuroImage, Vol 223, Iss , Pp 117318- (2020)
Diffusion functional magnetic resonance imaging (DfMRI) has been proposed as an alternative functional imaging method to detect brain activity without confounding hemodynamic effects. Here, taking advantage of this DfMRI feature, we investigated abno
Externí odkaz:
https://doaj.org/article/5135297929c14ac1afedf94662dc7293
Autor:
Shota Nakade, Keiji Mochida, Atsushi Kunii, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, Tetsushi Sakuma, Takashi Yamamoto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.
Externí odkaz:
https://doaj.org/article/7714049adc384aa7a9920f7849997032
Autor:
Zhenyu Dong, Yasuhiro Shinmei, Yoko Dong, Saori Inafuku, Junichi Fukuhara, Ryo Ando, Nobuyoshi Kitaichi, Atsuhiro Kanda, Kohichi Tanaka, Kousuke Noda, Takayuki Harada, Shinki Chin, Susumu Ishida
Publikováno v:
Heliyon, Vol 2, Iss 10, Pp e00191- (2016)
Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies, and lowering intraocular pressure is associated with an attenuation of progressive optic nerve damage. Nevertheless, intraocul
Externí odkaz:
https://doaj.org/article/7f974d45664b4c1e91c1aaa90eedfbb5
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36853 (2012)
BACKGROUND: Brains of patients with schizophrenia show both neurodevelopmental and functional deficits that suggest aberrant glutamate neurotransmission. Evidence from both genetic and pharmacological studies suggests that glutamatergic dysfunction,
Externí odkaz:
https://doaj.org/article/3a06d25e40314c08aa8affbfafff051b
Autor:
Takahiro Ito, Mikio Yoshida, Tomomi Aida, Itaru Kushima, Yuka Hiramatsu, Maiko Ono, Akira Yoshimi, Kohichi Tanaka, Norio Ozaki, Yukihiro Noda
Publikováno v:
Journal of Neurochemistry. 165:211-229
Autor:
Yosuke M. Morizawa, Mami Matsumoto, Yuka Nakashima, Narumi Endo, Tomomi Aida, Hiroshi Ishikane, Kaoru Beppu, Satoru Moritoh, Hitoshi Inada, Noriko Osumi, Eiji Shigetomi, Schuichi Koizumi, Guang Yang, Hirokazu Hirai, Kohichi Tanaka, Kenji F. Tanaka, Nobuhiko Ohno, Yugo Fukazawa, Ko Matsui
Publikováno v:
Nature Neuroscience. 25:1458-1469
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia participates in sculpting the neuronal circuits through synapse engulfment. However, whether glial involvement i
Autor:
Christine R. Rose, Mariko Onodera, Yuichi Hiraoka, Kenji F. Tanaka, Kota Furukawa, Jan Meyer, Ko Matsui, Tomomi Aida, Kohichi Tanaka
Publikováno v:
The Journal of Neuroscience. 41:2106-2118
Seizures invite seizures. At the initial stage of epilepsy, seizures intensify with each episode; however, the mechanisms underlying this exacerbation remain to be solved. Astrocytes have a strong control over neuronal excitability and the mode of in