Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Kohichi Kawahara"'
Autor:
Kentaro Jingushi, Masaya Aoki, Kazuhiro Ueda, Takahiro Kogaki, Masaya Tanimoto, Yuya Monoe, Masayuki Ando, Takuya Matsumoto, Kentaro Minami, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Toshiyuki Nagata, Aya Harada-Takeda, Masatatsu Yamamoto, Kohichi Kawahara, Kazuhiro Tabata, Tatsuhiko Furukawa, Masami Sato, Kazutake Tsujikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The human AlkB homolog family (ALKBH) of proteins play a critical role in some types of cancer. However, the expression and function of the lysine demethylase ALKBH4 in cancer are poorly understood. Here, we examined the expression and funct
Externí odkaz:
https://doaj.org/article/e39422a1faab4dfe81c736644fc55860
Autor:
Yuka Ishihara, Kiyoshiro Nakamura, Shunsuke Nakagawa, Yasuhiro Okamoto, Masatatsu Yamamoto, Tatsuhiko Furukawa, Kohichi Kawahara
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15986 (2022)
Nucleolar stress response is caused by perturbations in ribosome biogenesis, induced by the inhibition of ribosomal RNA processing and synthesis, as well as ribosome assembly. This response induces p53 stabilization and activation via ribosomal prote
Externí odkaz:
https://doaj.org/article/8ed47d46ad1b43aaa4ba461d8ad80804
Autor:
Shunsuke Nakagawa, Kohichi Kawahara, Yasuhiro Okamoto, Yuichi Kodama, Takuro Nishikawa, Yoshifumi Kawano, Tatsuhiko Furukawa
Publikováno v:
Cancers, Vol 14, Iss 20, p 5127 (2022)
Approximately 20% of pediatric patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) relapse or are refractory to chemotherapy despite the low frequency of TP53 mutations. The nucleolar stress response is a P53-activating mechanism vi
Externí odkaz:
https://doaj.org/article/d4737025ccfe4604a08e2463696296f2
Autor:
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Yuko Toyoda, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-ichi Akiyama
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Thymidine phosphorylase (TP) is a rate-limiting enzyme in the thymidine catabolic pathway. TP is identical to platelet-derived endothelial cell growth factor and contributes to tumour angiogenesis. TP induces the generation of reactive oxyge
Externí odkaz:
https://doaj.org/article/032a6e04b06a4f58b3f4b74ff4b3e639
Autor:
Toshiyuki Nagata, Kentaro Minami, Masatatsu Yamamoto, Tsubasa Hiraki, Masashi Idogawa, Katsumi Fujimoto, Shun Kageyama, Kazuhiro Tabata, Kohichi Kawahara, Kazuhiro Ueda, Ryuji Ikeda, Yukio Kato, Masaaki Komatsu, Akihide Tanimoto, Tatsuhiko Furukawa, Masami Sato
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11509 (2021)
Lung cancer constitutes a threat to human health. BHLHE41 plays important roles in circadian rhythm and cell differentiation as a negative regulatory transcription factor. This study investigates the role of BHLHE41 in lung cancer progression. We ana
Externí odkaz:
https://doaj.org/article/8a5678a30f1c4920bcc82d3506332165
Autor:
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-ichi Akiyama
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1313-1321 (2017)
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that TP-mediated thymidine catabolism could
Externí odkaz:
https://doaj.org/article/8226b180e12e490b9a291bd6e5e1a1d6
Publikováno v:
Biochemical and Biophysical Research Communications. 637:203-209
Ribosome biogenesis proceeds with the successive cleavage and trimming of the large 47S rRNA precursor, where the RNA exosome plays major roles in concert with the Ski2-like RNA helicase, MTR4. The recent finding of a consensus amino acid sequence, t
Autor:
Akira Suzuki, Motomu Manabe, Toru Nakano, Tak Wah Mak, Satoshi Itami, Masatake Osawa, Tetsunori Kimura, Friedrich Beermann, Itaru Kojima, Satoshi Eguchi, Hiroyuki Kishimoto, Masato Sasaki, Kohichi Kawahara, Sachiko Fujita, Sachiko Hatakeyama, Takehiko Sasaki, Koichi Hamada, Tae Inoue-Narita
Supplementary Figure 1 from Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7755fbd5f30013e0cf0b22ebe6e2daeb
https://doi.org/10.1158/0008-5472.22375695
https://doi.org/10.1158/0008-5472.22375695
Autor:
Masaki Mori, Satoru Miyano, Shizuo Komune, Akira Suzuki, Kohei Shibata, Fumiaki Tanaka, Tomoya Sudo, Seiya Imoto, Kohichi Kawahara, Koshi Mimori, Teppei Shimamura, Ryunosuke Kogo
PDF file - 173K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88274b52a29bf7a9872e099e3a5581a4
https://doi.org/10.1158/0008-5472.22389783.v1
https://doi.org/10.1158/0008-5472.22389783.v1
Autor:
Masaki Mori, Satoru Miyano, Shizuo Komune, Akira Suzuki, Kohei Shibata, Fumiaki Tanaka, Tomoya Sudo, Seiya Imoto, Kohichi Kawahara, Koshi Mimori, Teppei Shimamura, Ryunosuke Kogo
PDF file - 33K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3bdbd835baa5ea4dec199c7c5614d1
https://doi.org/10.1158/0008-5472.22389786
https://doi.org/10.1158/0008-5472.22389786