Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kohhei Tetsutani"'
Autor:
Nirianne Marie Q Palacpac, Edward Ntege, Adoke Yeka, Betty Balikagala, Nahoko Suzuki, Hiroki Shirai, Masanori Yagi, Kazuya Ito, Wakaba Fukushima, Yoshio Hirota, Christopher Nsereko, Takuya Okada, Bernard N Kanoi, Kohhei Tetsutani, Nobuko Arisue, Sawako Itagaki, Takahiro Tougan, Ken J Ishii, Shigeharu Ueda, Thomas G Egwang, Toshihiro Horii
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64073 (2013)
BACKGROUND: Up to now a malaria vaccine remains elusive. The Plasmodium falciparum serine repeat antigen-5 formulated with aluminum hydroxyl gel (BK-SE36) is a blood-stage malaria vaccine candidate that has undergone phase 1a trial in malaria-naive J
Externí odkaz:
https://doaj.org/article/d468acc1b0e04be69ab69d838b9721bb
Autor:
Tomomi Yamada, Kiyoshi Okada, Takahiro Tougan, Sumiyuki Nishida, Jyotheeswara R. Edula, Yuko Oishi, Kouji Yamamoto, Toshihiro Horii, Kohhei Tetsutani, Akira Myoui, Ken Ishii, Masanori Yagi, Sachiko Ezoe, Nirianne Marie Q. Palacpac, Masaki Taira, Haruhiko Hirata, Atsushi Ogata
Publikováno v:
Vaccine. 38:7246-7257
Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN(K3) (thus, BK-SE36/CpG) was assessed in a phase 1a trial in Japan. Methods A
Autor:
Shizuo Akira, Masayuki Hayashi, Cevayir Coban, Etsushi Kuroda, Kouji Kobiyama, Yoichiro Iwakura, Shohei Koyama, Yuko Katakai, Ken Ishii, Shinobu Saijo, Shinichi Mochizuki, Taiki Aoshi, Hirotaka Narita, Kohhei Tetsutani, Yasuhiro Yasutomi, Kazuo Sakurai
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3086-3091
CpG DNA, a ligand for Toll-like receptor 9 (TLR9), has been one of the most promising immunotherapeutic agents. Although there are several types of potent humanized CpG oligodeoxynucleotide (ODN), developing "all-in-one" CpG ODNs activating both B ce
Autor:
Chikako Moriya, Shinjiro Hamano, Xuefeng Duan, Chikako Shimokawa, Hajime Hisaeda, Jianying Shen, Kunisuke Himeno, Hidekazu Ishida, Kohhei Tetsutani, Bin Chou, Takashi Imai, Liping Tu
Publikováno v:
European Journal of Immunology. 40:1053-1061
When developing malaria vaccines, the most crucial step is to elucidate the mechanisms involved in protective immunity against the parasites. We found that CD8(+) T cells contribute to protective immunity against infection with blood-stage parasites
Autor:
Chikako Moriya, Shigeo Murata, Xuefeng Duan, Hajime Hisaeda, Kohhei Tetsutani, Liping Tu, Takashi Imai, Hidekazu Ishida, Kunisuke Himeno, Keiji Tanaka, Chikako Shimokawa
Publikováno v:
European Journal of Immunology. 39:3385-3394
Proteasome-mediated proteolysis is responsible for the generation of immunogenic epitopes presented by MHC class I molecules, which activate antigen-specific CD8+ T cells. Immunoproteasomes, defined by the presence of the three catalytic subunits LMP
Autor:
Xuefeng Duan, Bin Chou, Hidekazu Ishida, Hajime Hisaeda, Kumi Yoshida, Sakura Tanaka, Kohhei Tetsutani, Mamoru Hasegawa, Kunisuke Himeno, Yoshikazu Yonemitsu
Publikováno v:
Vaccine. 27:6154-6159
Chagas' disease, caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), is intractable showing a high mortality rate, and the development of effective vaccines is much desired. To examine the efficacy of a new mode of recombina
Autor:
Kunisuke Himeno, Kohhei Tetsutani, Kenji Ishiwata, Motomi Torii, Hajime Hisaeda, Liping Tu, Hidekazu Ishida, Shinjiro Hamano
Publikováno v:
European Journal of Immunology. 39:2822-2830
Malaria and intestinal nematode infection are widespread and co-infection frequently occurs. We investigated whether co-infected intestinal nematodes modulate immunity against co-existing malaria parasites. Infection of C57BL/6 mice with Plasmodium y
Autor:
Kunisuke Himeno, Kenji Ishiwata, Kohhei Tetsutani, Shinjiro Hamano, Hajime Hisaeda, Motomi Torii
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 79:819-822
We investigated whether concurrent infection with Heligmosomoides polygyrus, an intestinal nematode, modulated anti-malaria parasite immunity and development of experimental cerebral malaria (ECM) in mice. The C57BL/6 mice infected with Plasmodium be
Autor:
Koji Yasutomo, Hajime Hisaeda, Herman Waldmann, Chikage Mitoma-Obata, Kunisuke Himeno, Shinjiro Hamano, Kohhei Tetsutani, Takashi Imai
Publikováno v:
European Journal of Immunology. 35:3516-3524
CD4+ T cells are the major effector T cells against blood-stage Plasmodium yoelii infection. On the other hand, the lethal strain of P. yoelii (PyL) has acquired an escape mechanism from host T cell immunity by activating CD4+CD25+ regulatory T cells
Autor:
Bernard N. Kanoi, Adoke Yeka, Betty Balikagala, Shigeharu Ueda, Kohhei Tetsutani, Nahoko Suzuki, Christopher Nsereko, Masanori Yagi, Nobuko Arisue, Kazuya Ito, Hiroki Shirai, Nirianne Marie Q. Palacpac, Takahiro Tougan, Yoshio Hirota, Takuya Okada, Wakaba Fukushima, Toshihiro Horii, Thomas G. Egwang, Sawako Itagaki, Ken Ishii, Edward H. Ntege
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64073 (2013)
PLoS ONE
PLoS ONE
Background Up to now a malaria vaccine remains elusive. The Plasmodium falciparum serine repeat antigen-5 formulated with aluminum hydroxyl gel (BK-SE36) is a blood-stage malaria vaccine candidate that has undergone phase 1a trial in malaria-naive Ja