Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Kohei Sawada"'
Autor:
Jun‐ichi Okada, Takashi Yoshinaga, Takumi Washio, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 1092-1100 (2021)
Abstract The risk of fatal arrhythmias is the major concern for using chloroquine (CQ) or hydroxychloroquine (HCQ) to treat coronavirus disease 2019 (COVID‐19), but the reported number of life‐threatening arrhythmic events or deaths is relatively
Externí odkaz:
https://doaj.org/article/39cb3bdd46eb44579a0359d4cbb46fbb
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 4, Pp 313-316 (2019)
Using bright-field images of cultured human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we trained a convolutional neural network (CNN), a machine learning technique, to decide whether the qualities of cell cultures are suitable
Externí odkaz:
https://doaj.org/article/e2fd8fc0d9df4d60b03636c461892bab
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 233-239 (2018)
Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM
Externí odkaz:
https://doaj.org/article/f8bba6ec3dca42b591e093427eda3612
Autor:
Ksenia Blinova, Qianyu Dang, Daniel Millard, Godfrey Smith, Jennifer Pierson, Liang Guo, Mathew Brock, Hua Rong Lu, Udo Kraushaar, Haoyu Zeng, Hong Shi, Xiaoyu Zhang, Kohei Sawada, Tomoharu Osada, Yasunari Kanda, Yuko Sekino, Li Pang, Tromondae K. Feaster, Ralf Kettenhofen, Norman Stockbridge, David G. Strauss, Gary Gintant
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)
Summary: To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 dr
Externí odkaz:
https://doaj.org/article/3766b15437f1454ca223759395ad3b34
Autor:
Yuji Nakamura, Junko Matsuo, Norimasa Miyamoto, Atsuko Ojima, Kentaro Ando, Yasunari Kanda, Kohei Sawada, Atsushi Sugiyama, Yuko Sekino
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 4, Pp 494-501 (2014)
A prospective comparison study across 3 independent research laboratories of a pure IKr blocker E-4031 was conducted by using the same batch of human iPS cell–derived cardiomyocytes in order to verify the utility and reliability of our original sta
Externí odkaz:
https://doaj.org/article/43cf7ee99ae349fc9fd7487a969f9d4b
Autor:
Wataru Yamamoto, Keiichi Asakura, Hiroyuki Ando, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Tomoharu Osada, Seiji Hayashi, Chieko Kasai, Norimasa Miyamoto, Hiroyuki Tashibu, Takashi Yoshinaga, Daiju Yamazaki, Atsushi Sugiyama, Yasunari Kanda, Kohei Sawada, Yuko Sekino
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167348 (2016)
The aims of this study were to (1) characterize basic electrophysiological elements of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) that correspond to clinical properties such as QT-RR relationship, (2) determine the applica
Externí odkaz:
https://doaj.org/article/5b89cf1c65b04ff58b7beaa48cc3e498
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 4, Pp 517-528 (2008)
K+ channels are key modulators of neuronal excitability, and mutations in certain types of these channels are known to cause epileptic seizures. Activation of K+ channels is reported to suppress epileptic discharge; however, the types of K+-channel o
Externí odkaz:
https://doaj.org/article/69dfe8f11cc044518599e7c35f883699
Autor:
Kohei Sawada, Norimasa Miyamoto, Masao Iwata, Kotaro Kodama, Yukinori Minoshima, Kazuma Takase, Megumi Ikemori Kawada, Kiyoshi Okamoto, Yusuke Narita
PDF - 86K, Cleavaged -PARP induction in A375 and G361 parental cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fda413fcc7696489812e084a3521dc
https://doi.org/10.1158/1535-7163.22500801
https://doi.org/10.1158/1535-7163.22500801
Autor:
Kohei Sawada, Norimasa Miyamoto, Masao Iwata, Kotaro Kodama, Yukinori Minoshima, Kazuma Takase, Megumi Ikemori Kawada, Kiyoshi Okamoto, Yusuke Narita
PDF - 83K, Effect of vemurafenib, selumetinib, or E6201 on Cyclin D1 expression in exogenous MEK1-WT-positive or -negative A375 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a474bc8cb4b1e9fe9f11006ed75633c0
https://doi.org/10.1158/1535-7163.22500810.v1
https://doi.org/10.1158/1535-7163.22500810.v1
Autor:
Kohei Sawada, Norimasa Miyamoto, Masao Iwata, Kotaro Kodama, Yukinori Minoshima, Kazuma Takase, Megumi Ikemori Kawada, Kiyoshi Okamoto, Yusuke Narita
PDF - 68K, Effect of vemurafenib, selumetinib, or E6201 on Cyclin D1 expression in (A) exogenous MEK1-C121S-positive or -negative G361 cells and in (B) exogenous MEK1-WT-positive or -negative G361 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12305ed39ad8fa57e460db11a2b6c30d
https://doi.org/10.1158/1535-7163.22500804
https://doi.org/10.1158/1535-7163.22500804