Výsledky vyhledávání - "Kohei Nishino"

Akademický článek

Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding

Autor: Kohdai Yamada, Ryouhei Shioya, Kohei Nishino, Hirotake Furihata, Atsushi Hijikata, Mika K. Kaneko, Yukinari Kato, Tsuyoshi Shirai, Hidetaka Kosako, Tatsuya Sawasaki

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract Receptor proteins, such as epidermal growth factor receptor (EGFR), interact with other proteins in the extracellular region of the cell membrane to drive intracellular signalling. Therefore, analysis of extracellular protein-protein interac

Externí odkaz: https://doaj.org/article/e1786466eff242848bf775caca410fb3

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Akademický článek

Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation

Autor: Satoshi Yamanaka, Hirotake Furihata, Yuta Yanagihara, Akihito Taya, Takato Nagasaka, Mai Usui, Koya Nagaoka, Yuki Shoya, Kohei Nishino, Shuhei Yoshida, Hidetaka Kosako, Masaru Tanokura, Takuya Miyakawa, Yuuki Imai, Norio Shibata, Tatsuya Sawasaki

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Lenalidomide, an immunomodulatory drug (IMiD), is commonly used as a first-line therapy in many haematological cancers, such as multiple myeloma (MM) and 5q myelodysplastic syndromes (5q MDS), and it functions as a molecular glue for the pro

Externí odkaz: https://doaj.org/article/8b72605581dd46b6a05fd8d5de142a2e

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Akademický článek

A Wolbachia factor for male killing in lepidopteran insects

Autor: Susumu Katsuma, Kanako Hirota, Noriko Matsuda-Imai, Takahiro Fukui, Tomohiro Muro, Kohei Nishino, Hidetaka Kosako, Keisuke Shoji, Hideki Takanashi, Takeshi Fujii, Shin-ichi Arimura, Takashi Kiuchi

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. Here, the authors identify a Wolbachia protein that interacts with a host masculinization factor and leads to male killing i

Externí odkaz: https://doaj.org/article/d9e6530360de4eb5912aa02268dec64e

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Akademický článek

A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues

Autor: Satoshi Yamanaka, Yuto Horiuchi, Saya Matsuoka, Kohki Kido, Kohei Nishino, Mayaka Maeno, Norio Shibata, Hidetaka Kosako, Tatsuya Sawasaki

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

PROTACs and molecular glues target E3 ubiquitin ligases to substrate proteins. Here, the authors develop a proximity biotinylation-based method to identify drug-induced E3 ligase-substrate interactions, enabling the assessment of the target spectrum

Externí odkaz: https://doaj.org/article/5e14510e4bfc4a18b28054cf46f4d314

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Akademický článek

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway

Autor: Kohei Nishino, Seiji Watanabe, Jin Shijie, Yuri Murata, Kotaro Oiwa, Okiru Komine, Fumito Endo, Hitomi Tsuiji, Manabu Abe, Kenji Sakimura, Amit Mishra, Koji Yamanaka

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Intracellular mislocalization of TAR DNA-binding protein 43 (TDP-43), a nuclear DNA/RNA-binding protein involved in RNA metabolism, is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Although the aggregation-prone, TDP-43 C-t

Externí odkaz: https://doaj.org/article/8d04292fcff045b7bb7a14e4bdaedf76

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Akademický článek

Comparative proteomic analysis of mitochondria isolated from Euglena gracilis under aerobic and hypoxic conditions.

Autor: Shun Tamaki, Kohei Nishino, Takahisa Ogawa, Takanori Maruta, Yoshihiro Sawa, Kazuharu Arakawa, Takahiro Ishikawa

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0227226 (2019)

The unicellular microalga Euglena gracilis produces wax esters for ATP acquisition under low-oxygen conditions. The regulatory mechanism of wax ester production is not yet understood. Indeed, our previous transcriptomic analysis showed that transcrip

Externí odkaz: https://doaj.org/article/567da556f53840bb8bb59329bed13169

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Akademický článek

Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.

Autor: Kohei Nishino, Misaki Kushima, Yuzy Matsuo, Yasuhiro Matsuo, Makoto Kawamukai

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0141796 (2015)

Schizosaccharomyces pombe Δura4 cells lyse when grown on YPD medium. A S. pombe non-essential gene deletion library was screened to determine suppressors of the lysis phenotype. Deletion of the pub1 gene, which encoded E3 ubiquitin ligase, strongly

Externí odkaz: https://doaj.org/article/ef0eb5d2a8db48659811ce382d57048a

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