Výsledky vyhledávání - "Kohei Kikkawa"

Akademický článek

Thiourea as a "Polar Hydrophobic" Hydrogen-Bonding Motif: Application to Highly Durable All-Underwater Adhesion.

Autor: Kohei Kikkawa, Yosuke Sumiya, Kazuki Okazawa, Kazunari Yoshizawa, Yoshimitsu Itoh, Takuzo Aida

Publikováno v: Journal of the American Chemical Society; 7/31/2024, Vol. 146 Issue 30, p21168-21175, 8p

Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist

Autor: Toru Iijima, Makoto Katoh, Kei Takedomi, Yasuo Yamamoto, Hidenori Akatsuka, Naritoshi Shirata, Akito Nishi, Misae Takakuwa, Yoshinori Watanabe, Hitomi Munakata, Naomi Koyama, Tomoko Ikeda, Taku Iguchi, Harutoshi Kato, Kohei Kikkawa, Takayuki Kawaguchi

Publikováno v: Journal of Medicinal Chemistry. 65:8127-8143

Overactivation of the mineralocorticoid receptor (MR) is involved in many diseases, such as hypertension, kidney disease, and heart failure. Thus, MR antagonists (MRAs) are expected to be beneficial to patients with these diseases. In order to identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2388141a3f3a9176678419018354997
https://doi.org/10.1021/acs.jmedchem.2c00402

Zobrazit plný text záznamu

Surface Oxidation of Polymer 3D Porous Structures Using Chlorine Dioxide Radical Gas

Autor: Shunsuke Mizuno, Yu-I Hsu, Taka-Aki Asoh, Xinnan Cui, Kohei Kikkawa, Hiroshi Uyama

Publikováno v: ACS Applied Polymer Materials. 2:4964-4972

Recently, several studies have reported using an oxidation method, such as plasma, to introduce polar functional groups to the polymer surface. However, these methods are difficult to use to oxidiz...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a57c09ed228e5c747fd2d6a4c2a9b35
https://doi.org/10.1021/acsapm.0c00840

Zobrazit plný text záznamu

Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation

Autor: Kenji Matsuki, Masataka Hikota, Toshiaki Sakamoto, Koichiro Yamada, Hiroshi Morimoto, Jun Kotera, Michino Murakami, Kenji Omori, Yuichi Koga, Kohei Kikkawa, Kotomi Fujishige

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:5175-5180

5-(3,4,5-Trimethoxybenzoyl)-4-amimopyrimidine derivatives were found as a novel chemical class of potent and highly selective phosphodiesterase 5 inhibitors. A pseudo-ring formed by an intramolecular hydrogen bond constrained the conformation of 3-ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d30b83a518dc8e25821e74f434afe84
https://doi.org/10.1016/j.bmcl.2014.09.082

Zobrazit plný text záznamu

Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction

Autor: Takashi Sasaki, Yasuhiro Yamada, Jun Kotera, Hirotaka Inoue, Hideki Mochida, Kohei Kikkawa, Shiyin Yee, Kotomi Fujishige, Tsunehisa Noto, Kenji Omori, Koki Kojima, Tamaki Kobayashi

Publikováno v: Journal of Urology. 188:668-674

We investigated the in vitro inhibitory effects of avanafil, a novel, potent inhibitor of phosphodiesterase-5, on 11 phosphodiesterases. We also studied its potentiation of penile tumescence in dogs.Phosphodiesterase assay was done with the 4 phospho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ce5e5556cb73c1ef044fd17445be9e
https://doi.org/10.1016/j.juro.2012.03.115

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání