Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kohei Inamura"'
Autor:
Takeyuki Nagashima, Tomohiro Yoshinari, Yoshihiro Nishizono, Mamoru Tasaki, Kohei Inamura, Hiroki Ishioka, Atsushi Suzuki, Fumio Osaki, Yosuke Yamanaka, Masahiko Hayakawa
Publikováno v:
Cancer Research. 83:5735-5735
KRAS is one of the most frequently mutated oncogenes in various cancers. Among KRAS mutations, KRAS G12D is the most frequent driver mutation and is found in approximately 34% of patients with pancreatic ductal adenocarcinoma (PDAC), 12% of patients
Publikováno v:
European journal of pharmacology. 810
KCNH3 (BEC1) is a member of the ether-a-go-go (KCNH) family of voltage-gated K+ channels. The aim of this study was to determine the pharmacological profiles in vitro and in vivo of a KCNH3 inhibitor N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylme
Autor:
Akira Miyake, Shinji Takahashi, Masao Katou, Shunichiro Matsumoto, Kohei Inamura, Yukihiro Nakamura, Shinobu Mochizuki
Publikováno v:
The Journal of Neuroscience. 29:14637-14645
The K+channel, one of the determinants for neuronal excitability, is genetically heterogeneous, and various K+channel genes are expressed in the CNS. The therapeutic potential of K+channel blockers for cognitive enhancement has been discussed, but th
Autor:
Kohei Inamura, Hitoshi Matsushime, Kiyoshi Furuichi, Hidetsugu Okada, Yorikata Sano, Chika Kitada, Hiromichi Yokoi, Akira Miyake, Katsura Nozawa, Shinobu Mochizuki
Publikováno v:
Journal of Biological Chemistry. 278:27406-27412
To find a novel human ion channel gene we have executed an extensive search by using a human genome draft sequencing data base. Here we report a novel two-pore domain K+ channel, TRESK (TWIK-related spinal cord K+ channel). TRESK is coded by 385 amin
Autor:
Kiyoshi Furuichi, Chika Kitada, Shinobu Mochizuki, Hitoshi Matsushime, Hiromichi Yokoi, Kohei Inamura, Katsura Nozawa, Yorikata Sano, Akira Miyake
Publikováno v:
FEBS Letters. 512:230-234
We report identification and characterization of Kv6.3, a novel member of the voltage-gated K+ channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies indi
Autor:
Kohei Inamura, Kiyoshi Furuichi, Hitoshi Matsushime, Akira Miyake, Shinobu Mochizuki, Hiromichi Yokoi, Yorikata Sano
Publikováno v:
Science. 293:1327-1330
We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca 2+ influx into immunocytes. Intracellular pyrimidine nucleotides, aden
Autor:
Katsura Nozawa, Hitoshi Matsushime, Ryosuke Kojima, Toshihide Yokoyama, Yorikata Sano, Hidetsugu Okada, Kohei Inamura, Tomonobu Koizumi, Shinobu Mochizuki, Eri Kawabata-Shoda, Hiroyuki Ito, Hitoshi Doihara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(9)
Serotonin (5-hydroxytryptamine; 5-HT) is abundantly present throughout the gastrointestinal tract and stored mostly in enterochromaffin (EC) cells, which are located on the mucosal surface. 5-HT released from EC cells stimulate both intrinsic and ext
Autor:
Yorikata, Sano, Shinobu, Mochizuki, Akira, Miyake, Chika, Kitada, Kohei, Inamura, Hiromichi, Yokoi, Katsura, Nozawa, Hitoshi, Matsushime, Kiyoshi, Furuichi
Publikováno v:
FEBS letters. 512(1-3)
We report identification and characterization of Kv6.3, a novel member of the voltage-gated K(+) channel. Reverse transcriptase-polymerase chain reaction analysis indicated that Kv6.3 was highly expressed in the brain. Electrophysiological studies in
Autor:
Sano, Yorikata, Inamura, Kohei, Miyake, Akira, Mochizuki, Shinobu, Yokoi, Hiromichi, Matsushime, Hitoshi, Furuichi, Kiyoshi
Publikováno v:
Science. 8/17/2001, Vol. 293 Issue 5533, p1327-1330. 4p. 3 Diagrams, 1 Graph.