Výsledky vyhledávání - "Kohei Amakasu"

Renal Function and Hematology in Rats with Congenital Renal Hypoplasia

Autor: Hidenori, Yasuda, Kohei, Amakasu, Yuki, Tochigi, Kentaro, Katayama, Hiroetsu, Suzuki

Publikováno v: Comparative medicine. 66(1)

Renal hypoplasia due to a congenitally reduced number of nephrons progresses to chronic kidney disease and may cause renal anemia, given that the kidneys are a major source of erythropoietin in adults. Hypoplastic kidney (HPK) rats have only about 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a662a2588b4a195ccb44eba9392cfddd
https://pubmed.ncbi.nlm.nih.gov/26884405

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A spontaneous mutation of theWwoxgene and audiogenic seizures in rats with lethal dwarfism and epilepsy

Autor: Katsushi Suzuki, Kohei Amakasu, Kentaro Katayama, K. Saito, Hiroetsu Suzuki, M. Takenaka

Publikováno v: Genes, Brain and Behavior. 8:650-660

The lde/lde rat is characterized by dwarfism, postnatal lethality, male hypogonadism, a high incidence of epilepsy and many vacuoles in the hippocampus and amygdala. We used a candidate approach to identify the gene responsible for the lde phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eae89ce6e162f3ada0b804ec861e966
https://doi.org/10.1111/j.1601-183x.2009.00502.x

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Retarded Differentiation of Leydig Cells and Increased Apoptosis of Germ Cells in the Initial Round of Spermatogenesis of Rats With Lethal Dwarf and Epilepsy (lde/lde) Phenotypes

Autor: Kohei Amakasu, Hiroetsu Suzuki, Motoo Takenaka, Mio Yagi, Katsushi Suzuki

Publikováno v: Journal of Andrology. 29:669-678

The lde/lde rats show a severe dwarf phenotype with early postnatal lethality and a high incidence of epileptic seizure. Seizures are first detected in this model between 16 and 63 days of age, and mostly begin as wild running and progress to general

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c2cf983587a96ae3546b529156337a
https://doi.org/10.2164/jandrol.108.005066

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Note on Regulatory Toxicology Requirements for Adjuvants and Vaccines; in View of the Newly Established WHO Guidelines

Autor: Hajime Matsui, Kazutoshi Shinoda, Osamu Fueki, Kohei Amakasu, Kazuto Watanabe, Hiroshi Onodera, Shinichi Komatsu, Kazushige Maki, Kazuhiro Shimomura, Jun-ichi Sawada, Mineo Matsumoto

Publikováno v: Journal of Medical Toxicology and Clinical Forensic Medicine.

1 Review Division, Pharmaceuticals and Medical Devices Agency (PMDA), Kasumigaseki 3-3-2, Chiyoda-ku, Tokyo 100-0013, Japan 2 Research and Development Department, POC Clinical Research Inc. Taishidou 4-11, Setagaya-ku, Tokyo 154-0004, Japan 3 Patholo

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https://doi.org/10.21767/2471-9641.10008

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Considerations for non-clinical safety studies of therapeutic peptide vaccines

Autor: Jun-ichi Sawada, Mayumi Tsuchimoto, Mineo Matsumoto, Hajime Matsui, Shinichi Komatsu, Kazuto Watanabe, Kazuichi Nakamura, Kanako Ito, Kohei Amakasu, Kazushige Maki, Hiroshi Onodera, Osamu Fueki

Publikováno v: Regulatory toxicology and pharmacology : RTP. 70(1)

Guidelines for non-clinical studies of prophylactic vaccines against infectious diseases have been published widely, but similar guidelines for therapeutic vaccines, and especially therapeutic peptide vaccines, have yet to be established. The approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c9ff2ca3833e6b06fceb547700d408
https://pubmed.ncbi.nlm.nih.gov/25042360

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The unilateral urogenital anomalies (UUA) rat: a new mutant strain associated with unilateral renal agenesis, cryptorchidism, and malformations of reproductive organs restricted to the left side

Autor: Kohei, Amakasu, Katsushi, Suzuki, Hiroetsu, Suzuki

Publikováno v: Comparative medicine. 59(3)

We established an inbred rat strain with unilateral urogenital anomalies from an incidentally identified male rat with unilateral renal agenesis and an undescended left testis. These rats were characterized by unilateral renal agenesis in both sexes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::595caddb9d25aea14712b4e0dad4f5ac
https://pubmed.ncbi.nlm.nih.gov/19619415

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