Výsledky vyhledávání - "Kohei, Sawada"

Akademický článek

Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study

Autor: Jun‐ichi Okada, Takashi Yoshinaga, Takumi Washio, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada

Publikováno v: Clinical and Translational Science, Vol 14, Iss 3, Pp 1092-1100 (2021)

Abstract The risk of fatal arrhythmias is the major concern for using chloroquine (CQ) or hydroxychloroquine (HCQ) to treat coronavirus disease 2019 (COVID‐19), but the reported number of life‐threatening arrhythmic events or deaths is relatively

Externí odkaz: https://doaj.org/article/39cb3bdd46eb44579a0359d4cbb46fbb

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Akademický článek

Deep learning-based quality control of cultured human-induced pluripotent stem cell-derived cardiomyocytes

Autor: Ken Orita, Kohei Sawada, Ryuta Koyama, Yuji Ikegaya

Publikováno v: Journal of Pharmacological Sciences, Vol 140, Iss 4, Pp 313-316 (2019)

Using bright-field images of cultured human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), we trained a convolutional neural network (CNN), a machine learning technique, to decide whether the qualities of cell cultures are suitable

Externí odkaz: https://doaj.org/article/e2fd8fc0d9df4d60b03636c461892bab

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Akademický článek

Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update

Autor: Yasunari Kanda, Daiju Yamazaki, Tomoharu Osada, Takashi Yoshinaga, Kohei Sawada

Publikováno v: Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 233-239 (2018)

Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM

Externí odkaz: https://doaj.org/article/f8bba6ec3dca42b591e093427eda3612

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Akademický článek

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Publikováno v: Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)

Summary: To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 dr

Externí odkaz: https://doaj.org/article/3766b15437f1454ca223759395ad3b34

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Data from Novel ATP-Competitive MEK Inhibitor E6201 Is Effective against Vemurafenib-Resistant Melanoma Harboring the MEK1-C121S Mutation in a Preclinical Model

Autor: Kohei Sawada, Norimasa Miyamoto, Masao Iwata, Kotaro Kodama, Yukinori Minoshima, Kazuma Takase, Megumi Ikemori Kawada, Kiyoshi Okamoto, Yusuke Narita

Many clinical cases of acquired resistance to the BRAF inhibitor vemurafenib have recently been reported. One of the causes of this acquired resistance is the BRAF downstream kinase point mutation MEK1-C121S. This mutation confers resistance to not o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d10963634a99d6314e7ae3989d78d186
https://doi.org/10.1158/1535-7163.c.6536577.v1

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