Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

Autor: Weiner, Michael, Rajagopalan, P, Jahanshad, N, Stein, JL, Hua, X, Madsen, SK, Kohannim, O, Hibar, DP, Toga, AW, Jack, CR, Saykin, AJ

Publikováno v: Weiner, Michael; Rajagopalan, P; Jahanshad, N; Stein, JL; Hua, X; Madsen, SK; et al.(2012). Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8650z9sx

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::abda599b8a7b4b8f859b26de02c931b1
http://www.escholarship.org/uc/item/8650z9sx

Boosting power to detect genetic associations in imaging using multi-locus, genome-wide scans and ridge regression.

Autor: Kohannim, O., Hibar, D.P., Stein, J.L., Jahanshad, N., Jack, C.R., Weiner, M.W., Toga, A.W., Thompson, P.M.

Publikováno v: 2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro; 2011, p1855-1859, 5p

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Exhaustive search of the SNP-sNP interactome identifies epistatic effects on brain volume in two cohorts

Autor: Hibar, D. P., Jason Stein, Jahanshad, N., Kohannim, O., Toga, A. W., Mcmahon, K. L., Zubicaray, G. I., Montgomery, G. W., Martin, N. G., Wright, M. J., Weiner, M. W., Thompson, P. M.

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::683bd59530e090079a6040732f30fb95
http://www.scopus.com/inward/record.url?eid=2-s2.0-84894613231&partnerID=MN8TOARS

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