Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kohal Das"'
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158794 (2016)
G-quadruplexes are one of the most commonly studied non-B DNA structures. Generally, these structures are formed using a minimum of 4, three guanine tracts, with connecting loops ranging from one to seven. Recent studies have reported deviation from
Externí odkaz:
https://doaj.org/article/fe38fc4c81e24731b5d5109256adffd9
Publikováno v:
DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
Accumulating evidence suggests that human genome can fold into non-B DNA structures, when appropriate sequence and favourable conditions are present. Among these, G-quadruplexes (G4-DNA) are associated with gene regulation, chromosome fragility and t
Autor:
Simran Kaushal, Alice Haouzi, Catherine H. Freudenreich, Samantha B. Regan, Ryan P. Barnes, Soo Mi Lee, Suzanne E. Hile, Kohal Das, Kristin A. Eckert, Charles E. Wollmuth, Nealia C.M. House, Michael Guyumdzhyan
Publikováno v:
SSRN Electronic Journal.
Summary Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast