Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Koh-ichi Utani"'
Autor:
Noriaki Shimizu, Rita Kapoor, Shuhei Naniwa, Naoto Sakamaru, Taku Yamada, You-ki Yamamura, Koh-ichi Utani
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Extrachromosomal acentric double minutes (DMs) contribute to human malignancy by carrying amplified oncogenes. Recent cancer genomics revealed that the pulverization of defined chromosome arms (chromothripsis) may generate DMs, ho
Externí odkaz:
https://doaj.org/article/9302f9a1aa0d4276a3ac991fc087f145
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27233 (2011)
Micronucleation, mediated by interphase nuclear budding, has been repeatedly suggested, but the process is still enigmatic. In the present study, we confirmed the previous observation that there are lamin B1-negative micronuclei in addition to the po
Externí odkaz:
https://doaj.org/article/011083e07e0b45e6bfdcabf0d9ddb98f
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10089 (2010)
The presence of micronuclei in mammalian cells is related to several mutagenetic stresses. In order to understand how micronuclei emerge, behave in cells, and affect cell fate, we performed extensive time-lapse microscopy of HeLa H2B-GFP cells in the
Externí odkaz:
https://doaj.org/article/e67f1d95ea65460faeb01e64184f639f
Autor:
Naoto Sakamaru, Noriaki Shimizu, Taku Yamada, Rita Kapoor, You-ki Yamamura, Shu-hei Naniwa, Koh-ichi Utani
Publikováno v:
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-15 (2019)
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-15 (2019)
Background Extrachromosomal acentric double minutes (DMs) contribute to human malignancy by carrying amplified oncogenes. Recent cancer genomics revealed that the pulverization of defined chromosome arms (chromothripsis) may generate DMs, however, no
Publikováno v:
Mutagenesis. 27:323-327
A micronucleus is a small nucleus-like structure found in the cytoplasm of dividing cells that suffered from genotoxic stress. It is generally hypothesised that micronuclei content is eventually lost from cells, though the mechanism of how this occur
Autor:
Koh-ichi Utani, Noriaki Shimizu
Publikováno v:
Nucleic Acids Research
Heterochromatin is critical for genome integrity, and recent studies have suggested the importance of transcription in heterochromatin for maintaining its silent state. We previously developed a method to generate a large homogeneously staining regio
Publikováno v:
Molecular Cancer Research. 5:695-704
Extrachromosomal double minutes (DM) bear amplified genes that contribute to the malignancy of human cancer cells. A novel intracellular behavior of DMs resulted in their selective entrapment within micronuclei; opening the vista, this could perturb
Publikováno v:
Genes, Chromosomes and Cancer. 46:865-874
Gene amplification plays a pivotal role in human malignancy. Highly amplified genes frequently localize to extrachromosomal double minutes (dmin), which usually segregate to daughter cells in association with mitotic chromosomes. We and others had sh
Publikováno v:
Journal of Cellular Biochemistry. 102:515-529
We previously showed that plasmids containing a mammalian replication initiation region and a matrix attachment region were efficiently amplified to few thousand copies per cell, and that they formed extrachromosomal double minutes (DMs) or chromosom
We used fluorescence in situ hybridization (FISH) to detect c-myc RNA subspecies in human COLO 320DM tumor cells. Although the FISH procedure removed the majority of RNAs from the nucleolus, c-myc RNA continued to be detected in both the nucleoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b02c488f600e8eda4f8198974d3710
http://ir.lib.hiroshima-u.ac.jp/00020744
http://ir.lib.hiroshima-u.ac.jp/00020744