Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Koh Ida"'
Autor:
Shuuichi Miyakawa, Hiroyuki Sakuma, Dnyaneshwar Warude, Satomi Asanuma, Naoto Arimura, Tomoki Yoshihara, Daniel Tavares, Akito Hata, Koh Ida, Yuri Hori, Yuumi Okuzono, Syunsuke Yamamoto, Koichi Iida, Hisao Shimizu, Shinichi Kondo, Shuji Sato
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying
Externí odkaz:
https://doaj.org/article/1bfd1d0933a04c75b1f1c53ea0ed5fe5
Autor:
Yosuke Sato, Cierra N. Casson, Atsushi Matsuda, James I. Kim, Judy Qiuju Shi, Shinji Iwasaki, Susan Chen, Brett Modrell, Chingkit Chan, Daniel Tavares, Douglas Austen, Koh Ida, Olga Tayber, Pyae Hein, Robert Comeau, Yafang Lin, Michael H. Shaw
Publikováno v:
Cancer Immunology, Immunotherapy. 71:2421-2431
Ipilimumab, a monoclonal antibody that recognizes cytotoxic T-lymphocyte associated protein 4 (CTLA-4), was the first immune checkpoint inhibitor approved by the FDA to treat metastatic melanoma patients. Multiple preclinical studies have proposed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487812ab51e1103050ebdd7de9df9697
https://doi.org/10.1007/s00262-022-03170-z
https://doi.org/10.1007/s00262-022-03170-z
Autor:
Shuji Sato, Yuumi Okuzono, Tomoki Yoshihara, Akito Hata, Hiroyuki Sakuma, Shuuichi Miyakawa, Koh Ida, Koichi Iida, Naoto Arimura, Dnyaneshwar Warude, Syunsuke Yamamoto, Daniel Tavares, Shinichi Kondo, Hisao Shimizu, Yuri Hori, Satomi Asanuma
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience, Vol 14 (2020)
Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce6d69f0613c05db94c688983ae4f3
https://pubmed.ncbi.nlm.nih.gov/33384578
https://pubmed.ncbi.nlm.nih.gov/33384578
Autor:
Robert E. Davis, Lawrence P. Wennogle, Peng Li, Joseph P. Hendrick, Satoshi Sogabe, Wei Yao, Gyorgy Snell, Hailin Zheng, J. David Beard, Zhao Jun, Gretchen L. Snyder, Lei Zhang, Weston Lane, Koh Ida, Charles J. Heyser, Hongwen Zhu, Kimberly E. Vanover
Publikováno v:
Journal of Medicinal Chemistry. 59:1149-1164
A diverse set of 3-aminopyrazolo[3,4-d]pyrimidinones was designed and synthesized. The structure-activity relationships of these polycyclic compounds as phosphodiesterase 1 (PDE1) inhibitors were studied along with their physicochemical and pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3066c51d76f3966da5e391d0f5e78a3
https://doi.org/10.1021/acs.jmedchem.5b01751
https://doi.org/10.1021/acs.jmedchem.5b01751
Autor:
Satoshi Sogabe, Tomoya Sameshima, Kotaro Sakamoto, Takeshi Yamamoto, Junichi Sakamoto, Gotou Mika, Osamu Sano, Koh Ida, Ikuo Miyahisa, Yasuhiro Imaeda, Shigeru Igaki
Publikováno v:
Biochemistry. 57(8)
B-cell lymphoma 6 (BCL6) is the most frequently involved oncogene in diffuse large B-cell lymphomas (DLBCLs). BCL6 shows potent transcriptional repressor activity through interactions with its corepressors, such as BCL6 corepressor (BCOR). The inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bf75482c9aab39025500267ab0e2c9
https://pubmed.ncbi.nlm.nih.gov/29293322
https://pubmed.ncbi.nlm.nih.gov/29293322
Autor:
Junichi Sakamoto, Hideyuki Oki, Motoo Iida, Nozomu Sakai, Junji Matsui, Koh Ida, Yasuhiro Imaeda, Gyorgy Snell, Yusuke Kamada, Satoshi Sogabe, Kotaro Sakamoto, Weston Lane
Publikováno v:
Journal of medicinal chemistry. 60(10)
B-cell lymphoma 6 (BCL6) is a transcriptional factor that expresses in lymphocytes and regulates the differentiation and proliferation of lymphocytes. Therefore, BCL6 is a therapeutic target for autoimmune diseases and cancer treatment. This report p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb749c95edc7c361c8dd589987d163e
https://pubmed.ncbi.nlm.nih.gov/28471657
https://pubmed.ncbi.nlm.nih.gov/28471657
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 73:2274-2280
Annexin A4 (Anx4) possesses four repeat domains with one Ca(2+)-binding site (CBS) in each domain. In this study, we resolved two crystal structures of the Na(+)-bound form at high resolution (1.58 and 1.35 A). This is the first report that Anx4 bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18920e5feea416457d787ac443fbb59
https://doi.org/10.1271/bbb.90366
https://doi.org/10.1271/bbb.90366
Autor:
Masashi Kurabayashi, Haruo Suzuki, Takaaki Hikima, Masaki Yamomoto, Masaya Suguro, Koh Ida, Yuhta Hiruma
Publikováno v:
Journal of Biological Chemistry. 283:16584-16590
The mature form of l-phenylalanine oxidase (PAOpt) from Pseudomonas sp. P-501 was generated and activated by the proteolytic cleavage of a noncatalytic proenzyme (proPAO). The crystal structures of proPAO, PAOpt, and the PAOpt-o-amino benzoate (AB) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605dcc9aa5afc9aa6151abbdda7ead2c
https://doi.org/10.1074/jbc.m800366200
https://doi.org/10.1074/jbc.m800366200
Publikováno v:
Journal of Structural and Functional Genomics. 7:15-22
RIKEN Structural Genomics Beamlines, BL26B1 & BL26B2 at the SPring-8, have been constructed for the structural genomics research. The main feature of the beamline is full automation of the successive data collections to maximize the beam-time efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8713e15466846d425b5d62032029dcb4
https://doi.org/10.1007/s10969-005-9005-5
https://doi.org/10.1007/s10969-005-9005-5
Publikováno v:
Biochemical and Biophysical Research Communications. 333:359-366
Sarcosine oxidase from Corynebacterium sp. U-96 is a heterotetrameric enzyme. Here we report the crystal structures of the enzyme in complex with dimethylglycine and folinic acid. The a subunit is composed of two domains, contains NAD + , and binds f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9484bbdf4b5d6e74e58a69520d2bb7
https://doi.org/10.1016/j.bbrc.2005.05.116
https://doi.org/10.1016/j.bbrc.2005.05.116