HflX controls hypoxia-induced non-replicating persistence in slow growing mycobacteria

Autor: Koh Hqv, Ng Sw, Ngan Sfc, Cho Sls, Julien Lescar, Kevin Pethe, Abdulghani N, Huan Jia, Jun Yi Stanley Lim, Sylvie Alonso, Wilford Tse, Ngan Jyg, Jaafar Mt, Swathi Pasunooti, Wei Meng, Siu Kwan Sze

GTPase HflX is highly conserved in prokaryotes and is a ribosome splitting factor during heat shock in E. coli. Here we report that HflX produced by slow growing M. tuberculosis and M. bovis BCG is a GTPase that plays a critical role in the pathogen�

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HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.

Autor: Ngan JYG; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Pasunooti S; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Tse W; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Meng W; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Ngan SFC; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Jia H; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Lin JQ; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Ng SW; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Jaafa MT; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Cho SLS; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Lim J; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Koh HQV; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Abdul Ghani N; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore., Pethe K; School of Biological Sciences, Nanyang Technological University, 637551 Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, 636921 Singapore., Sze SK; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Lescar J; School of Biological Sciences, Nanyang Technological University, 637551 Singapore., Alonso S; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117456 Singapore; micas@nus.edu.sg.; Life Sciences Institute, Immunology Programme, National University of Singapore, 117456 Singapore.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 23; Vol. 118 (12).