The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer.

Autor: Nardin JM; Clinical Research Department, Erasto Gaertner Hospital, Curitiba, Brazil.; School of Health Science, UniBrasil, Curitiba, Brazil.; Pontifical Catholic University of Parana, Curitiba, Brazil., Schroth W; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Almeida TA; Clinical Oncology Department, Erasto Gaertner Hospital, Curitiba, Brazil., Mürdter T; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Picolotto S; Pharmacy Department, Erasto Gaertner Hospital, Curitiba, Brazil., Vendramini ECL; Pharmacy Department, Erasto Gaertner Hospital, Curitiba, Brazil., Hoppe R; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Kogin JP; School of Health Science, UniBrasil, Curitiba, Brazil., Miqueleto D; School of Health Science, UniBrasil, Curitiba, Brazil., de Moraes SDR; School of Health Science, UniBrasil, Curitiba, Brazil., Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tuebingen, Tuebingen, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; iFIT Cluster of Excellence, University of Tuebingen, Tuebingen, Germany., Pecoits-Filho RF; Pontifical Catholic University of Parana, Curitiba, Brazil., Brauch H; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; iFIT Cluster of Excellence, University of Tuebingen, Tuebingen, Germany., Casali-da-Rocha JC; Pontifical Catholic University of Parana, Curitiba, Brazil.; Department of Oncogenetics, Erasto Gaertner Hospital, Curitiba, Brazil.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2020 Mar; Vol. 13 (2), pp. 284-292. Date of Electronic Publication: 2019 Nov 09.