Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.

Autor: Wilk CM; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cathomas F; Nash Family Department of Neuroscience, Brain & Body Research Center, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Török O; Department of Neurology, University of Pécs, Medical School, Pécs, Hungary., Le Berichel J; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Park MD; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bigenwald C; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Gustave Roussy Cancer Campus, Villejuif, France; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France., Heaton GR; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hamon P; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Troncoso L; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Scull BP; Texas Children's Cancer Center, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Dangoor D; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Artificial Intelligence, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Neuropathology Brain Bank and Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Silvin A; Gustave Roussy Cancer Campus, Villejuif, France; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France., Fleischmann R; Texas Children's Cancer Center, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Belabed M; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lin H; Texas Children's Cancer Center, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Merad Taouli E; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Boettcher S; Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland., Li L; Nash Family Department of Neuroscience, Brain & Body Research Center, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Aubry A; Nash Family Department of Neuroscience, Brain & Body Research Center, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Manz MG; Department of Medical Oncology and Hematology, University of Zurich and University Hospital Zurich, Zurich, Switzerland., Kofler JK; Division of Neuropathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Yue Z; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lira SA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ginhoux F; Gustave Roussy Cancer Campus, Villejuif, France; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France., Crary JF; Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Artificial Intelligence, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Neuropathology Brain Bank and Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McClain KL; Texas Children's Cancer Center, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA., Picarsic JL; Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Russo SJ; Nash Family Department of Neuroscience, Brain & Body Research Center, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Allen CE; Texas Children's Cancer Center, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. Electronic address: ceallen@texaschildrens.org., Merad M; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: miriam.merad@mssm.edu.

Publikováno v: Immunity [Immunity] 2023 Dec 12; Vol. 56 (12), pp. 2790-2802.e6.

CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.

Autor: Nguyen JN; University of Texas McGovern Medical School at Houston, Houston, TX, USA., Mohan EC; University of Texas McGovern Medical School at Houston, Houston, TX, USA., Pandya G; Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA., Ali U; Baylor University, Waco, TX, USA., Tan C; Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA., Kofler JK; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Shapiro L; Center for Vascular Biology, The University of Connecticut Health Center, Farmington, CT, USA., Marrelli SP; Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA., Chauhan A; Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA. anjali.chauhan@uth.tmc.edu.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2023 Oct 10; Vol. 20 (1), pp. 232. Date of Electronic Publication: 2023 Oct 10.

Vesicular Glutamate Transporter Changes in the Cortical Default Mode Network During the Clinical and Pathological Progression of Alzheimer's Disease.

Autor: Mi Z; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA., Abrahamson EE; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA., Ryu AY; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Malek-Ahmadi M; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Department of Biomedical Informatics, University of Arizona College of Medicine, Phoenix, AZ, USA., Kofler JK; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fish KN; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sweet RA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Villemagne VL; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Mufson EJ; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Departments of Translational Neurosciences and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA., Ikonomovic MD; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 94 (1), pp. 227-246.

NADPH oxidase 2 activity in Parkinson's disease.

Autor: Keeney MT; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Hoffman EK; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Farmer K; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Bodle CR; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Fazzari M; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Zharikov A; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Castro SL; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Hu X; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Mortimer A; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Kofler JK; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Cifuentes-Pagano E; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Pagano PJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA., Burton EA; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA., Hastings TG; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Greenamyre JT; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Di Maio R; Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: rod16@pitt.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2022 Aug; Vol. 170, pp. 105754. Date of Electronic Publication: 2022 May 13.

Deep learning from multiple experts improves identification of amyloid neuropathologies.

Autor: Wong DR; Bakar Computational Health Sciences Institute, University of California, San Francisco, CA, 94158, USA.; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California, San Francisco, CA, 94158, USA., Tang Z; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94158, USA., Mew NC; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94158, USA., Das S; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, 95817, USA., Athey J; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, 95817, USA., McAleese KE; Translation and Clinical Research Institute, Newcastle University, Newcastle, UK., Kofler JK; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15260, USA., Flanagan ME; Department of Pathology, Northwestern University, Evanston, IL, 60208, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern Medicine, Chicago, IL, 60611, USA., Borys E; Department of Pathology, Loyola University Medical Center, Maywood, IL, 60153, USA., White CL 3rd; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Butte AJ; Bakar Computational Health Sciences Institute, University of California, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California, San Francisco, CA, 94158, USA.; Center for Data-Driven Insights and Innovation, University of California, Office of the President, Oakland, CA, 94607, USA., Dugger BN; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, 95817, USA. bndugger@ucdavis.edu., Keiser MJ; Bakar Computational Health Sciences Institute, University of California, San Francisco, CA, 94158, USA. keiser@keiserlab.org.; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, 94158, USA. keiser@keiserlab.org.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA. keiser@keiserlab.org.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, 94158, USA. keiser@keiserlab.org.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Apr 28; Vol. 10 (1), pp. 66. Date of Electronic Publication: 2022 Apr 28.