Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

Autor: Éric Dumont, Lusine Abrahamyan, Stuart Mccluskey, Angela Jerath, Humara Poonawala, Andrew Stevens, Jeannie Callum, Alan Tinmouth, Daniel Wong, Gianluigi Bisleri, Tarit Saha, David Mazer, Hilary Grocott, Jane Yang, Jeff Kinney, Yoan Lamarche, Damon Scales, George Tomlinson, Fuad Moussa, Andrew Shih, Michelle Zeller, Melanie Tokessy, Keyvan Karkouti, Vivek Rao, Summer Syed, Lilia Kaustov, Sophia Wong, Lani Lieberman, Kamrouz Ghadimi, Philippe Demers, Penny Johnson, Jerrold H Levy, Justyna Bartoszko, Miki Peer, Michael Law, Michelle Wong, Mackenzie Quantz, Antoine Rochon, Fraser Rubens, Shagun Jain, Yulia Lin, Katerina Pavenski, Deep Grewal, Deborah DuMerton, Darrin Payne, Saba Ansari, Robert Mayer, Rebecca Randall, Aftab Malik, Bethany Smethurst, Laura Molnar, Angela Sirosky-Yanyk, Mark Peterson, Christopher Harle, Etienne Couture, Diem Tran, Cristina Solomon, Sigurd Knaub, Kenichi A Tanaka, Blaine Achen, Sukhpal Brar, Matthew Coley, Dana Devine, Alana Flexman, Camila Machado de Souza, Maria Rosal Martins, Terri Sun, Rob Tanzola, Mathew Yan, Raffael Zamper, Jo Carrol, Nishanthi Liyanage, Simryn Selby, Reezanoor Kabir, Shelley Oliver, Alioska Escorcia, Susana Medic, Michelle Mozel, Ramanjot Kaur, Kelly Bizovie, Sarah Buchko, Raven Arly Gonzales, Korey Sutherland, Jenna Van Roekel, Alveena Babul, Ken Tanaka, Kofi Vandyck, Amir Butt, Hisako Okada, Robert Tanzola, Reegan Tod, Aiden Scholey, Wafaa Haider, Ester Cisneros-Aguilera, Alexandre Bergeron, Genevieve Belanger, Darren Mullane, Bevan Hughes, Sakara Hutspardol, Shirley Lim, Jian Mi, Debbie Kalar, Matthew Eang, Erick Lorenzana-Saldivar, Edward P Chen, Akash Gupta, Philip Lau, Pablo Perez D’Empaire, Chantal Armali, Amie Malkin, Connie Colavecchia, Harley Meirovich, Annie Bergeron, Francois Laforge, Kim Paradis, Nathalie Gagne, Marie Soleil Saillant, Marie-Claude Vézina, Olivier Royer, Marie-Ève Charest, Lee-Anne Fochesato, Yuxin Bai, Iqbal Jaffar, Nour Alhomsi, Janine Guevarra, Erin Jamula, Wan Chien (Betty) Hsu, Abbey Drew, Hakan Buyukdere, Drashtee Patel, Elizabeth Watt, Hadia Arabi Katbi, Kim Luciano, Amy Moorehead, Kamola Kasimova, Farzana Tasmin, Cielo Bingley, Victoria Barkley, Tob Reegan, Marianna Qu, Jessica Xiong, Sophie Robichaud, Christy Peterson, Manu Jairath, Mathew Tang, Jennita Aariaratnam, Leron DuMerton, Lucas Drew, Sahrish Masood, Toni Tidy, Elizabeth Krok

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor p

Externí odkaz: https://doaj.org/article/f4b23ce7268143bca04256dccb1c3cbf

Diagnosis of Microvascular Bleeding After Cardiopulmonary Bypass—A Game of Hide and Seek

Autor: Srikiran Ramarapu, John McNeil, Kenichi A. Tanaka, Kofi Vandyck

Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5411362db6797d04a04a13b3897d2254
https://doi.org/10.1053/j.jvca.2023.03.039

Thrombin Generation in Trauma Patients: How Do we Navigate Through Scylla and Charybdis?

Autor: Alexander Y. Mitrophanov, Kofi Vandyck, Kenichi A. Tanaka

Publikováno v: Current Anesthesiology Reports. 12:308-319

Purpose of Review Coagulopathy is a complex pathological condition manifested through the insufficient or excessive tendency to form blood thrombi, which can be caused by trauma and surgery. A promising strategy to mitigate coagulopathy is the balanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::859740f21e3085f4d5bcedcc23244471
https://doi.org/10.1007/s40140-021-00502-0

Management of Patients With Hemophilia Undergoing Cardiac Surgery

Autor: Kenichi A. Tanaka, Daniel Bolliger, Kofi Vandyck

Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia. 36:539-541

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eaa230d7e4e5e565578a4bac478a20
https://doi.org/10.1053/j.jvca.2021.11.022

Walking a Thin Line

Autor: Kofi Vandyck, Casey Windrix, Elyse C. Wyatt, Kenichi A. Tanaka

Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia. 37:190-191

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c2457d333c05db77cc98d49e6943d1
https://doi.org/10.1053/j.jvca.2022.10.008