Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Koert N.J. Burger"'
Publikováno v:
Journal of Raman Spectroscopy. 40:763-769
Cellular lipid droplets are organelles that carry out important functions such as the regulated storage and release of cholesterol and fatty acids (FAs). Lipid droplets therefore play a key role in both healthy metabolism and metabolic disorders such
Autor:
Anke Deggerich, Koert N.J. Burger, Anna V. Bulankina, Markus G. Rudolph, Kudzai Mutenda, Julia G. Wittmann, Dirk Wenzel, Stefan Höning
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology
TIP47 (tail-interacting protein of 47 kD) was characterized as a cargo selection device for mannose 6-phosphate receptors (MPRs), directing their transport from endosomes to the trans-Golgi network. In contrast, our current analysis shows that cytoso
Publikováno v:
Biophysical Journal, 95(10), 4908-4914. Biophysical Society
Lipid droplets (LDs) are highly dynamic organelles that perform multiple functions, including the regulated storage and release of cholesterol and fatty acids. Information on the molecular composition of individual LDs within their cellular context i
Autor:
Vladimir Chupin, Karen M. Carter, Ben de Kruijff, Edgar E. Kooijman, Koert N.J. Burger, Emma G. van Laar
Publikováno v:
Biochemistry. 44:17007-17015
Phosphatidic acid and lysophosphatidic acid are minor but important anionic bioactive lipids involved in a number of key cellular processes, yet these molecules have a simple phosphate headgroup. To find out what is so special about these lipids, we
Autor:
Massimo Micaroni, Pierfrancesco Marra, Alberto Luini, Willie J. C. Geerts, Alvar Trucco, Alexander A. Mironov, Daniele Di Giandomenico, Oliviano Martella, Abraham J. Koster, Aurora Fusella, Galina V. Beznoussenko, Alessio Di Pentima, Koert N.J. Burger, Hee Seok Kweon, Roman S. Polishchuk, Eric G. Berger
Publikováno v:
Molecular Biology of the Cell. 15:4710-4724
In the most widely accepted version of the cisternal maturation/progression model of intra-Golgi transport, the polarity of the Golgi complex is maintained by retrograde transport of Golgi enzymes in COPI-coated vesicles. By analyzing enzyme localiza
Publikováno v:
Biophysical Journal. 85(6):3813-3827
Membrane transport within mammalian cells is mediated by small vesicular as well as large pleiomorphic transport carriers (TCs). A major step in the formation of TCs is the creation and subsequent narrowing of a membrane neck connecting the emerging
Autor:
Alexander A Mironov, Galina V Beznoussenko, Alvar Trucco, Pietro Lupetti, Jeffrey D Smith, Willie J.C Geerts, Abraham J Koster, Koert N.J Burger, Maryann E Martone, Thomas J Deerinck, Mark H Ellisman, Alberto Luini
Publikováno v:
Developmental Cell. 5:583-594
Protein transport between the ER and the Golgi in mammalian cells occurs via large pleiomorphic carriers, and most current models suggest that these are formed by the fusion of small ER-derived COPII vesicles. We have examined the dynamics and struct
Publikováno v:
Traffic. 4:162-174
The local generation of phosphatidic acid plays a key role in the regulation of intracellular membrane transport through mechanisms which are largely unknown. Phosphatidic acid may recruit and activate downstream effectors, or change the biophysical
Autor:
Koert N.J. Burger, Hanke C. de Vijlder, Rutger W.H.M. Staffhorst, Maria J. Velinova, Peter M. Frederik, Paul H. H. Bomans, Ben de Kruijff
Publikováno v:
Nature Medicine. 8:81-84
Cisplatin is one of the most widely used agents in the treatment of solid tumors, but its clinical utility is limited by toxicity. The development of less toxic, liposomal formulations of cisplatin has been hampered by the low water solubility and lo
Autor:
Alvar Trucco, Abraham J. Koster, Alexander A. Mironov, Alberto Luini, Galina V. Beznoussenko, Koert N.J. Burger, Pietro Lupetti, Daniele Di Giandomenico, Eric G. Berger, Willie J. C. Geerts, Paolo Nicoziani, Oliviano Martella, Hee Seok Kweon, Aurora Fusella, Roman S. Polishchuk
Publikováno v:
The Journal of Cell Biology
Procollagen (PC)-I aggregates transit through the Golgi complex without leaving the lumen of Golgi cisternae. Based on this evidence, we have proposed that PC-I is transported across the Golgi stacks by the cisternal maturation process. However, most