Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Koert Gerzon"'
Autor:
Henry R. Besch, Keshore R. Bidasee, Koert Gerzon, William Welch, Alan J. Williams, Andrew Tinker, John L. Sutko, Judith A. Airey, Luc Ruest, Pierre Deslongchamps
Publikováno v:
Biophysical Journal. 70(5):2110-2119
We have examined the effects of a number of derivatives of ryanodine on K+ conduction in the Ca2+ release channel purified from sheep cardiac sarcoplasmic reticulum (SR). In a fashion comparable to that of ryanodine, the addition of nanomolar to micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3605153ff075df9f499385bbd8184ca4
Publikováno v:
Molecular and Cellular Biochemistry. :145-160
The plant alkaloids ryanodine and dehydroryanodine are high affinity, biphasic modulators of the intracellularly located, calcium-regulated calcium release channels of a variety of cell types. To date, little is certain about the molecular basis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8188ad5cd26b66e8e090e47f6b38cca4
https://doi.org/10.1007/bf01076573
https://doi.org/10.1007/bf01076573
Autor:
Rod A. Humerickhouse, Henry R. Besch, Keshore R. Bidasee, Jeffrey T. Emmick, John L. Sutko, Koert Gerzon, Sangyeol Kwon, Luc Ruest
Publikováno v:
Journal of Biological Chemistry. 269:30243-30253
The plant alkaloids ryanodine and dehydroryanodine are specific and potent modulators of the sarcoplasmic reticulum calcium release channel. In the present study, acidic, basic, and neutral side chains esters of these diterpene compounds were prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1beff0c8617ac2250c92b1c426baae50
https://doi.org/10.1016/s0021-9258(18)43804-5
https://doi.org/10.1016/s0021-9258(18)43804-5
Autor:
John L. Sutko, Luc Ruest, Pierre Deslongchamps, Henry R. Besch, Koert Gerzon, Syed S. Ahmad, William Welch, Judith A. Airey, Rod A. Humerickhouse
Publikováno v:
Biochemistry. 33:6074-6085
Ryanodine binds to specific membrane proteins, altering the calcium permeability of intracellular membranes. In this study 19 ryanoids were isolated or synthesized and the structures correlated to the strength of binding to vertebrate skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b17d743d4eeadfb571d61b8fb69d753
https://doi.org/10.1021/bi00186a006
https://doi.org/10.1021/bi00186a006
Autor:
Koert Gerzon, Keshore R. Bidasee, Jeffrey T. Emmick, Rod A. Humerickhouse, Kurt T. Besch, Sangyeol Kwon, Henry R. Besch
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:33-47
A high affinity, photoactivatable, radio-iodinated ligand for the ryanodine binding site(s) of the sarcoplasmic reticulum calcium-release-channel, C10-Oeq-N-(4-azido-5-125iodo salicyloyl)-β-alanyl-β-alanyl ryanodine (Az-βAR), was synthesized at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::126226e99bca3e54421e4d7d77b904f0
https://doi.org/10.1002/jlcr.2580340106
https://doi.org/10.1002/jlcr.2580340106
Autor:
Rod A. Humerickhouse, Keshore R. Bidasee, Jeffrey T. Emmick, Luc Ruest, Koert Gerzon, Roger W. Roeske, John L. Sutko, Henry R. Besch, Zhenping Tian
Publikováno v:
Journal of Medicinal Chemistry. 36:1319-1323
Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic reticulum Ca(2+)-release channel (SR CRC). In the presence of DCC and DMAP Cbz-beta-alanin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d903262d9cc271a353ddfcd7406e1ff
https://doi.org/10.1021/jm00062a003
https://doi.org/10.1021/jm00062a003
Autor:
John L. Sutko, Luc Ruest, Keshore R. Bidasee, Henry R. Besch, Pierre Deslongchamps, Kathy E. Mitchell, Koert Gerzon, Alan J. Williams, Judith A. Airey, William Welch, J. Lamothe, Andrew Tinker
Publikováno v:
Biochemistry. 36(10)
Comparative molecular field analysis (CoMFA) was used to analyze the relationship between the structure of a group of ryanoids and the modulation of the calcium channel function of the ryanodine receptor. The conductance properties of ryanodine recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18fe1832857161b1cc3c91a14d21e13
https://pubmed.ncbi.nlm.nih.gov/9062124
https://pubmed.ncbi.nlm.nih.gov/9062124
Publikováno v:
Signal Transduction Mechanisms ISBN: 9781461358336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e730113960ec8093c10b73c71b486f17
https://doi.org/10.1007/978-1-4615-2015-3_16
https://doi.org/10.1007/978-1-4615-2015-3_16
Publikováno v:
European journal of pharmacology. 268(3)
An 125I-iodinated ryanodine analog, modified by attaching an iodo-Cbz-β-alanyl group to the C10eq hydroxy of ryanodine (iodo-carbobenzyloxy-β-alanyl-ryanodine), binds to cardiac sarcoplasmic reticulum Ca2+ release channels with equal affinity as [3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8553d3b739c3e5e3f344c2eb02d02b
https://pubmed.ncbi.nlm.nih.gov/7805760
https://pubmed.ncbi.nlm.nih.gov/7805760
Publikováno v:
Steroids. 48:223-231
Propargyl amine was protected by condensing it with 2,5-hexanedione to give 2,5-dimethyl-N-(2'-propyn-l1-yl)pyrrole ( 2 ). The latter was converted to the corresponding Grignard reagent with ethylmaqnesium bromide, and then condensed with estrone tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3149d83200e8ec741aea9357baabf8
https://doi.org/10.1016/0039-128x(86)90005-x
https://doi.org/10.1016/0039-128x(86)90005-x