Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Koenraad Van Doorslaer"'
Autor:
Anne Van Arsdale, Lauren Turker, Yoke-Chen Chang, Joshua Gould, Bryan Harmon, Elaine C. Maggi, Olga Meshcheryakova, Maxwell P. Brown, Dana Luong, Koenraad Van Doorslaer, Mark H. Einstein, Dennis Y. S. Kuo, Deyou Zheng, Brian J. Haas, Jack Lenz, Cristina Montagna
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-19 (2024)
Abstract HPV infections are associated with a fraction of vulvar cancers. Through hybridization capture and DNA sequencing, HPV DNA was detected in five of thirteen vulvar cancers. HPV16 DNA was integrated into human DNA in three of the five. The ins
Externí odkaz:
https://doaj.org/article/59a9007ade2647f4815ca3ad85b8e52e
Autor:
Mark S Lee, Peter J Tuohy, Caleb Y Kim, Philip P Yost, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
Publikováno v:
eLife, Vol 12 (2024)
CD4+ T cell activation is driven by five-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling module
Externí odkaz:
https://doaj.org/article/e90d0627576a424cb17384af3076cd76
Autor:
Mary C. Bedard, Tafadzwa Chihanga, Adrean Carlile, Robert Jackson, Marion G. Brusadelli, Denis Lee, Andrew VonHandorf, Mark Rochman, Phillip J. Dexheimer, Jeffrey Chalmers, Gerard Nuovo, Maria Lehn, David E. J. Williams, Aditi Kulkarni, Molly Carey, Amanda Jackson, Caroline Billingsley, Alice Tang, Chad Zender, Yash Patil, Trisha M. Wise-Draper, Thomas J. Herzog, Robert L. Ferris, Ady Kendler, Bruce J. Aronow, Matthew Kofron, Marc E. Rothenberg, Matthew T. Weirauch, Koenraad Van Doorslaer, Kathryn A. Wikenheiser-Brokamp, Paul F. Lambert, Mike Adam, S. Steven Potter, Susanne I. Wells
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The role of keratinocyte subpopulations in the different phases of the viral cycle during HPV16 infection remains to be characterised. Here, single cell RNA sequencing of HPV16 infected and uninfected organoids identifies 12 distinct keratinocyte pop
Externí odkaz:
https://doaj.org/article/944133d8df914bc3ab573aab9d9f4d14
Autor:
Matteo Rizzato, Fuxiang Mao, Florian Chardon, Kun-Yi Lai, Ruth Villalonga-Planells, Hannes C. A. Drexler, Marion E. Pesenti, Mert Fiskin, Nora Roos, Kelly M. King, Shuaizhi Li, Eduardo R. Gamez, Lilo Greune, Petra Dersch, Claudia Simon, Murielle Masson, Koenraad Van Doorslaer, Samuel K. Campos, Mario Schelhaas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Human papillomavirus (HPV) coopts mitosis for nuclear entry by tethering the viral DNA to mitotic chromosomes, a process facilitated by the viral minor capsid protein L2. Here, Rizzato et al. show that L2 contains conserved phosphorylation motifs wit
Externí odkaz:
https://doaj.org/article/b57b1e1f90134a7ead1de9a3cb32c825
Autor:
Felicia Goodrum, Anice C. Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael J. Imperiale, Walter Atwood, Daphne Avgousti, Joel Baines, Bruce Banfield, Lawrence Banks, Sumita Bhaduri-McIntosh, Deepta Bhattacharya, Daniel Blanco-Melo, David Bloom, Adrianus Boon, Steeve Boulant, Curtis Brandt, Andrew Broadbent, Christopher Brooke, Craig Cameron, Samuel Campos, Patrizia Caposio, Gary Chan, Anna Cliffe, John Coffin, Kathleen Collins, Blossom Damania, Matthew Daugherty, Kari Debbink, James DeCaprio, Terence Dermody, Jimmy Dikeakos, Daniel DiMaio, Rhoel Dinglasan, W. Paul Duprex, Rebecca Dutch, Nels Elde, Michael Emerman, Lynn Enquist, Bentley Fane, Ana Fernandez-Sesma, Michelle Flenniken, Lori Frappier, Matthew Frieman, Klaus Frueh, Michaela Gack, Marta Gaglia, Tom Gallagher, Denise Galloway, Adolfo García-Sastre, Adam Geballe, Britt Glaunsinger, Stephen Goff, Alexander Greninger, Meaghan Hancock, Eva Harris, Nicholas Heaton, Mark Heise, Ekaterina Heldwein, Brenda Hogue, Stacy Horner, Edward Hutchinson, Joseph Hyser, William Jackson, Robert Kalejta, Jeremy Kamil, Stephanie Karst, Frank Kirchhoff, David Knipe, Timothy Kowalik, Michael Lagunoff, Laimonis Laimins, Ryan Langlois, Adam Lauring, Benhur Lee, David Leib, Shan-Lu Liu, Richard Longnecker, Carolina Lopez, Micah Luftig, Jennifer Lund, Balaji Manicassamy, Grant McFadden, Michael McIntosh, Andrew Mehle, W. Allen Miller, Ian Mohr, Cary Moody, Nathaniel Moorman, Anne Moscona, Bryan Mounce, Joshua Munger, Karl Münger, Eain Murphy, Mojgan Naghavi, Jay Nelson, Christopher Neufeldt, Janko Nikolich, Christine O'Connor, Akira Ono, Walter Orenstein, David Ornelles, Jing-hsiung Ou, John Parker, Colin Parrish, Andrew Pekosz, Philip Pellett, Julie Pfeiffer, Richard Plemper, Stephen Polyak, John Purdy, Dohun Pyeon, Miguel Quinones-Mateu, Rolf Renne, Charles Rice, John Schoggins, Richard Roller, Charles Russell, Rozanne Sandri-Goldin, Martin Sapp, Luis Schang, Scott Schmid, Stacey Schultz-Cherry, Bert Semler, Thomas Shenk, Guido Silvestri, Viviana Simon, Gregory Smith, Jason Smith, Katherine Spindler, Megan Stanifer, Kanta Subbarao, Wesley Sundquist, Mehul Suthar, Troy Sutton, Andrew Tai, Vera Tarakanova, Benjamin tenOever, Scott Tibbetts, Stephen Tompkins, Zsolt Toth, Koenraad van Doorslaer, Marco Vignuzzi, Nicholas Wallace, Derek Walsh, Michael Weekes, Jason Weinberg, Matthew Weitzman, Sandra Weller, Sean Whelan, Elizabeth White, Bryan Williams, Christiane Wobus, Scott Wong, Andrew Yurochko
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines an
Externí odkaz:
https://doaj.org/article/88d633fd96714f98a0ed8b9526e9581b
Autor:
Natalie Payne, Leigh Combrink, Simona Kraberger, Rafaela S. Fontenele, Kara Schmidlin, Ivonne Cassaigne, Melanie Culver, Arvind Varsani, Koenraad Van Doorslaer
Publikováno v:
Frontiers in Ecology and Evolution, Vol 11 (2023)
With viruses often having devastating effects on wildlife population fitness and wild mammals serving as pathogen reservoirs for potentially zoonotic diseases, determining the viral diversity present in wild mammals is both a conservation and One Hea
Externí odkaz:
https://doaj.org/article/36bb4643761b4b00b06e206ffabc8ee5
Autor:
Peter Simmonds, Evelien M Adriaenssens, F Murilo Zerbini, Nicola G A Abrescia, Pakorn Aiewsakun, Poliane Alfenas-Zerbini, Yiming Bao, Jakub Barylski, Christian Drosten, Siobain Duffy, W Paul Duprex, Bas E Dutilh, Santiago F Elena, Maria Laura García, Sandra Junglen, Aris Katzourakis, Eugene V Koonin, Mart Krupovic, Jens H Kuhn, Amy J Lambert, Elliot J Lefkowitz, Małgorzata Łobocka, Cédric Lood, Jennifer Mahony, Jan P Meier-Kolthoff, Arcady R Mushegian, Hanna M Oksanen, Minna M Poranen, Alejandro Reyes-Muñoz, David L Robertson, Simon Roux, Luisa Rubino, Sead Sabanadzovic, Stuart Siddell, Tim Skern, Donald B Smith, Matthew B Sullivan, Nobuhiro Suzuki, Dann Turner, Koenraad Van Doorslaer, Anne-Mieke Vandamme, Arvind Varsani, Nikos Vasilakis
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3001922 (2023)
A universal taxonomy of viruses is essential for a comprehensive view of the virus world and for communicating the complicated evolutionary relationships among viruses. However, there are major differences in the conceptualisation and approaches to v
Externí odkaz:
https://doaj.org/article/96bb6b363e8243c3807b87ccfa3b966e
Autor:
Robert Jackson, Esha V Rajadhyaksha, Reid S Loeffler, Caitlyn E Flores, Koenraad Van Doorslaer
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292368 (2023)
Three-dimensional (3D) culturing techniques can recapitulate the stratified nature of multicellular epithelial tissues. Organotypic 3D epithelial tissue culture methods have several applications, including the study of tissue development and function
Externí odkaz:
https://doaj.org/article/c2212db77b2744f19c8032825748866b
Publikováno v:
Tumour Virus Research, Vol 14, Iss , Pp 200248- (2022)
Papillomaviruses have been evolving alongside their hosts for at least 450 million years. This review will discuss some of the insights gained into the evolution of this diverse family of viruses. Papillomavirus evolution is constrained by pervasive
Externí odkaz:
https://doaj.org/article/ce5129a814e94dacb5e26c841a6243fb
Autor:
Mark S Lee, Peter J Tuohy, Caleb Y Kim, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
Publikováno v:
eLife, Vol 11 (2022)
CD4+ T cells use T cell receptor (TCR)–CD3 complexes, and CD4, to respond to peptide antigens within MHCII molecules (pMHCII). We report here that, through ~435 million years of evolution in jawed vertebrates, purifying selection has shaped motifs
Externí odkaz:
https://doaj.org/article/ee02f986cdcb478ea9094352a35c5524