Výsledky vyhledávání - "Koenraad Jozef Lodewijk Marcel Andries"

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

Autor: P. A. J. Janssen, Christopher J. Michejda, S.H. Hughes, Y. Hsiou, Eddy Arnold, Arthur D. Clark, S Jessen, Jianping Ding, Kalyan Das, Rudi Pauwels, Xiaode Lu, Wanyi Zhang, Richard H. Smith, Chris Tantillo, Luc Koymans, Henri Moereels, Koenraad Jozef Lodewijk Marcel Andries, Alfredo Jacobo-Molina, M.Kroeger Koepke

Publikováno v: Structure. 3:365-379

Background: HIV-1 reverse transcriptase (RT) is a multifunctional enzyme that copies the RNA genome of HIV-1 into DNA. It is a heterodimer composed of a 66 kDa (p66) and a 51 kDa (p51) subunit. HIV-1 RT is a crucial target for structure-based drug de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2813ef76a71bfcae3ecae25e4bff338a
https://doi.org/10.1016/s0969-2126(01)00168-x

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A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis for a more rational screening program

Autor: B. Dewindt, Paul J. Lewi, R. Stokbroekx, R. Willebrords, Koenraad Jozef Lodewijk Marcel Andries, J. Snoeks

Publikováno v: Antiviral Research. 16:213-225

A systematic evaluation of 15 rhinovirus capsid-binding agents against all 100 serotyped human rhinoviruses revealed the existence of two virus groups, based upon differential susceptibility to antiviral compounds. Elongated and short-chained compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bc1344073a1f3486cb5142a28f9a72
https://doi.org/10.1016/0166-3542(91)90001-8

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Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity

Autor: Henri Moereels, J. Snoeks, P. A. J. Janssen, Leo Wouters, Pj Lewi, B. Dewindt, Koenraad Jozef Lodewijk Marcel Andries

Publikováno v: Journal of Virology. 64:1117-1123

A variety of chemically different compounds inhibit the replication of several serotypes of rhinoviruses (common-cold viruses). We noticed that one of these antiviral compounds, WIN 51711, had an antiviral spectrum clearly distinctive from a consensu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6409f629807f930f36c444b5e943a695
https://doi.org/10.1128/jvi.64.3.1117-1123.1990

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Comparison of the Anti-Influenza Virus Activity of RWJ-270201 with Those of Oseltamivir and Zanamivir

Autor: L. L. Horn, C. D. Parker, Pravin L. Kotian, John A. Montgomery, A. Dehghani, Y.S. Babu, D. L. Kellog, Tsu-Hsing Lin, Koenraad Jozef Lodewijk Marcel Andries, Shanta Bantia, Y. El-Kattan, T. L. Hutchison, Sandya L Ananth, Pooran Chand

Publikováno v: Antimicrobial agents and chemotherapy

We have recently reported an influenza virus neuraminidase inhibitor, RWJ-270201 (BCX-1812), a novel cyclopentane derivative discovered through structure-based drug design. In this paper, we compare the potency of three compounds, RWJ-270201, oseltam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41b7ee5142ce1fd0b28a130142b25e9
https://europepmc.org/articles/PMC90439/

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Discovery, development and characterization of agents active against the AIDS virus

Autor: Paul Stoffels, Rudi Pauwels, M.-P. De Bethune, E. De Clercq, Koenraad Jozef Lodewijk Marcel Andries, P. A. J. Janssen

Publikováno v: Journal of receptor and signal transduction research. 15(1-4)

Despite major efforts by academic and pharmaceutical research teams, no definitive prevention or cure of AIDS has been achieved. Nevertheless, this research has yielded important information on how HIV replicates and causes disease. Moreover, several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4f47e1300f5251f7d77d5281fcef74
https://pubmed.ncbi.nlm.nih.gov/8903967

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In vitro activity of pirodavir (R 77975): a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity

Autor: P. A. J. Janssen, Koenraad Jozef Lodewijk Marcel Andries, R. Willebrords, R. Stokbroekx, B. Dewindt, J. Snoeks, K. Van Eemeren

Publikováno v: Antimicrobial agents and chemotherapy

Pirodavir (R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds. Although its predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) at concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f8ec7eb86bcefd5e7bdb4630aa42e0
https://hdl.handle.net/10067/39850151162165141

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