The case against censoring of progression-free survival in cancer clinical trials – A pandemic shutdown as an illustration

Autor: Corinne Jamoul, Laurence Collette, Elisabeth Coart, Koenraad D’Hollander, Tomasz Burzykowski, Everardo D. Saad, Marc Buyse

Publikováno v: BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-10 (2022)

Abstract Background Missing data may lead to loss of statistical power and introduce bias in clinical trials. The Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials. Although several endpoi

Externí odkaz: https://doaj.org/article/de73c70f1fb345dbb3320e5b12c3a082

Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE):a randomised, open-label, non-inferiority, phase 3 trial

Autor: Michael L Schilsky, Anna Czlonkowska, Massimo Zuin, David Cassiman, Carlos Twardowschy, Aurelia Poujois, Francisco de Assis A Gondim, Gerald Denk, Rubens G Cury, Peter Ott, Joanna Moore, Aftab Ala, Renata D'Inca, Eduardo Couchonnal-Bedoya, Koenraad D'Hollander, Nicolas Dubois, C Omar F Kamlin, Karl Heinz Weiss, Uyen To, Amar Patel, Daksshi Hettiarachchi, Alessia Giorgini, Sara Monico, Tomasz Litwin, Agnieszka Piechal, Marta Skowronska, Alain Lachaux, Abdelouahed Belmalih, Alexandra Boogers, Isabelle Mohr, Andrea Langel, Christian Freitas, Egberto Reis Barbosa, Thomas D Sandahl, Lisbet Gerdes, Alexandre Obadia, Djamila Rahli, Jeremy Cosgrove

Publikováno v: CHELATE trial investigators 2022, ' Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE) : a randomised, open-label, non-inferiority, phase 3 trial ', The Lancet Gastroenterology and Hepatology, vol. 7, no. 12, pp. 1092-1102 . https://doi.org/10.1016/S2468-1253(22)00270-9

Background: Wilson disease is an inherited disorder of copper transport. Whereas penicillamine is used therapeutically to re-establish copper balance, trientine is indicated for patients with penicillamine intolerance. We aimed to compare penicillami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc08a6d996987fd1d2dba0c63b14f359
https://pure.au.dk/portal/da/publications/trientine-tetrahydrochloride-versus-penicillamine-for-maintenance-therapy-in-wilson-disease-chelate(ba317b8b-40a9-4b06-9881-6e93f059c2ea).html

MPN-147: Dynamic and Time-To-Event Analyses Demonstrate Marked Reduction in Transfusion Requirements for Janus Kinase Inhibitor-Naïve Myelofibrosis Patients Treated with Momelotinib Compared Head to Head with Ruxolitinib

Autor: Ruben A. Mesa, Miklos Egyed, Rafe Donahue, Jean-Jacques Kiladjian, Donal P. McLornan, Stephen T. Oh, John Catalano, Koenraad d'Hollander, Kazuya Shimoda, Mark Kowalski, Elisabeth Coart, Francisco Cervantes, Jason Gotlib, Timothy Devos

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 20:S329-S330

Background: Systemic inflammation integral to the pathogenesis of myelofibrosis (MF) leads to increased ACVR1 activity and hepcidin production, resulting in perturbed iron homeostasis and iron-restricted anemia. Chronic, progressive anemia is a key h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cfeea1ef51a8bfded4b949660e47a39
https://doi.org/10.1016/s2152-2650(20)30991-5

Abstract S3-01: IMENEO: International MEta-analysis of circulating tumor cell detection in early breast cancer patients treated by NEOadjuvant chemotherapy

Autor: JA Garcia-Saenz, Fabien Reyal, Patrice Viens, Denise M. Wolf, Jun Horiguchi, Stefan Michiels, Wendy Onstenk, F-C Bidard, F-A Taran, John W. Park, Koenraad d'Hollander, Noriyoshi Fujisawa, Jose Vidal-Martinez, L Muinelo, Hideaki Tokiniwa, Klaus Pantel, Anthony Lucci, N Name, Jeffrey B. Smerage, Justin Stebbing, Carolyn S. Hall, Jaco Kraan, S Riethdorf, Eduardo Díaz-Rubio, Rin Nagaoka, Rafael Gisbert-Criado, Antonio Llombart-Cussac, Michail Ignatiadis, J-Y Pierga, Sara Y. Brucker, B Naume, F Rothe, Sibylle Loibl, Charlotte Proudhon, Elin Borgen, M. Maestro, O Engebråtenm, M Toi, Vicente Carañana, M Gopalkrishna Karhade, Cappelletti, R Ruud Mathiesen, A Hartkopf, Dominic Amara, Daisuke Takata, D Generali, V Mueller, LJ Esserman, M Magbanua, J Bowman Bauldry, K Weber, S Sleijfer, Paul Cottu

Publikováno v: Cancer Research. 77:S3-01

Background We performed an international meta-analysis of individual patient data to assess the clinical validity of circulating tumor cell (CTC) count in non-metastatic breast cancer (BC) patients (pts) treated by neoadjuvant chemotherapy (NCT). Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c597fd2c240aaae656cb00b21902dde
https://doi.org/10.1158/1538-7445.sabcs16-s3-01