Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Koen Wuyts"'
1
Toward simplified oral lipid-based drug delivery using mono-/di-glycerides as single component excipients
Autor: René Holm, Koen Wuyts, Ruzica Kolakovic, Brendan T. Griffin, Martin Kuentz, Filip Cuyckens, Alexandra Roxana Ilie, Maria Vertzoni
Publikováno v: Drug Development and Industrial Pharmacy
This study aimed to systematically explore compositional effects for a series of lipid systems, on the in vitro drug solubilization and in vivo bioavailability of three poorly water-soluble drugs with different physico-chemical properties. While many
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc88a0e5b0bc15833b2590922259b7a
https://hdl.handle.net/10468/10811
Zobrazit plný text záznamu
2
Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport
Autor: Lieve Dillen, Jan Snoeys, Ulla Gro Nielsen, A. Kahnt, Rasmus Blaaholm Nielsen, Carsten Uhd Nielsen, Koen Wuyts, René Holm
Publikováno v: Nielsen, R B, Kahnt, A, Dillen, L, Wuyts, K, Snoeys, J, Nielsen, U G, Holm, R & Nielsen, C U 2019, ' Montmorillonite-surfactant hybrid particles for modulating intestinal P-glycoprotein-mediated transport ', International Journal of Pharmaceutics, vol. 571, 118696 . https://doi.org/10.1016/j.ijpharm.2019.118696
In the small intestine, P-glycoprotein (P-gp) may limit the permeability of its substrates, which lead to reduced oral absorption. To circumvent the effect of P-gp, a nanocomposite material termed montmorillonite-surfactant hybrid particles was devel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250c219c57217d47e9d5d99662cc84ab
https://findresearcher.sdu.dk:8443/ws/files/155569609/Montmorillonite_surfactant_hybrid_particles_for_modulating_intestinal_P_glycoprotein_mediated_transport.pdf
Zobrazit plný text záznamu
3
Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI
Autor: J. Van Audekerke, Jelle Veraart, Jan Sijbers, Claire Mackie, Elisabeth Jonckers, Roland Willems, Michele Giugliano, Koen Wuyts, Marleen Verhoye, L. Ver Donck, João Couto, Thomas Steckler, A. Van der Linden, S. Sekar, Stefanie Dedeurwaerdere
Publikováno v: Psychopharmacology
Psychopharmacology; Vol 227
Background An effective NMDA antagonist imaging modelmay find key utility in advancing schizophrenia drug discoveryresearch. We investigated effects ofsubchronictreatmentwith the NMDA antagonist memantine by usingbehavioural observation and multimoda
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf57340ee8849c6a6c06e2e39af20bd
Zobrazit plný text záznamu
4
New model for intravenous drug administration and blood sampling in the awake rat, designed to increase quality and throughput for in vivo pharmacokinetic analysis
Autor: Marjoleen J.M.A Nijsen, Petra Gysemberg, Philip Timmerman, Marc Haseldonckx, Koen Wuyts, Claire Mackie, Iris Verhoeven, Saskia Blokland
Publikováno v: Journal of Pharmacological and Toxicological Methods. 52:293-301
Introduction: There is a continuing need for increased throughput in the examination of new chemical entities (NCEs) in terms of the pharmacokinetic (PK) parameters. The aim was to validate a new study method designed to improve throughput and reduce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0698b91e8a609c36daaeba66cb99c1
https://doi.org/10.1016/j.vascn.2004.11.002
Zobrazit plný text záznamu
5
In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor
Autor: Koen Wuyts, Pieter Annaert, Clive J. Roberts, Guy Van den Mooter, David J. Scurr, Joke Meeus, Katie Amssoms, Martyn C. Davies
Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 199
At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90675c889159a3882384afbd65d67249
https://pubmed.ncbi.nlm.nih.gov/25485732
Zobrazit plný text záznamu
7
Prediction of human oral plasma concentration-time profiles using preclinical data: comparative evaluation of prediction approaches in early pharmaceutical discovery
Autor: Luc Bijnens, Roel Straetemans, Denise Morrison, Koen Wuyts, Vikash K. Sinha, Ron A. H. J. Gilissen, An Van den Bergh, Claire Mackie
Publikováno v: Clinical pharmacokinetics. 50(8)
Empirically based methods remain one of our tools in human pharmacokinetic predictions. The Dedrick approach and the steady-state plasma drug concentration (C(ss))-mean residence time (MRT) approach are based on the assumption that concentration-time
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd2a3060edadc439a128d88796ca7a
https://pubmed.ncbi.nlm.nih.gov/21740074
Zobrazit plný text záznamu
8
Structural and electronic properties of mixed Au/Te/n-GaAs structures
Autor: Jan Watte, Roger Silverans, Koen Wuyts
Publikováno v: Hyperfine Interactions. 79:627-631
The structural and electronic properties of the intermixed interfaces of layered Au/Te/n-GaAs structures were investigated by the combined application of129I Mossbauer spectroscopy (in the decay of129mTe), X-ray diffraction, Raman spectroscopy and el
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b925ad44f5b59b85443acaa47706ca25
https://doi.org/10.1007/bf00567586
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje